Sentences with phrase «with nuclear families»

I work with nuclear families, blended families and adoptive families who are living in chaos.

The new industrial cities created enormous freedom: people moved to the cities and lived there alone, or with their nuclear families, but without the significant community ties that simultaneously offered moral guidance and limited their choices.

This is clearest with the nuclear family, but of course it is not limited to that.

It involves a sacred period with the baby, an intense focus on breast feeding, time alone with the nuclear family, and a need for bonding that some in my middle America culture may find odd or even think it's extreme.

You are the traitor to your forefathers, people who envisioned a society that started with the nuclear family as the base of all society.

At a special dinner with his nuclear family and parish priest, he learns that his family's perfect life is about to keel over as his four children decide to come out of their various closets...

I spent Black Friday in the city with my nuclear family.

We can help you and your husband sort out what are reasonable requests from your mother in law, based on that family's «culture,» and what is unreasonable because it interferes with your nuclear family's culture.

Extended family members are often engaged in treatment interventions along with nuclear family members.

Not exact matches

They found that whites were overly associated with categories like nostalgia (craftspeople and tradition), natural (wholesome foods, agriculture) and the stereotypical nuclear family.

I hope to convince J.D. that while I grew up with very liberal, Jewish parents (dad from South America) in California, and in a nuclear family without alcohol or violence, I experienced surprisingly similar parallels to many of J.D.'s societal views — even if we may have drawn moderately different conclusions about the underlying solutions.

Daniel and Elizabeth's experience (and that of couples like them) makes an important truth very clear: The current practice of middle - class American marriage, with its atomized nuclear families, sparse and carefully spaced offspring, and long empty - nesting period before grandchildren arrive, is a recipe for dissatisfaction.

Knowledgeable members of his audience assumed that he was confusing the nuclear mother - father team with the traditional or modern family.

The distinction between the nuclear and traditional family was also blurred in the recent report on human sexuality by the Presbyterian Church (U.S.A.) titled Keeping Body and Soul Together: «Although many Christians in the post-World War II era have a special emotional attachment to the nuclear family, with its employed father, mother at home, and two or more school - aged children, that profile currently fits only 5 percent of North American households.»

Some Protestant leaders are striving to broaden the church's ministry to include the growing plurality of family forms — to include as coequals with the intact nuclear family all single - parent families, the divorced and remarried, blended families, childless couples, unmarried couples living together, and gay and lesbian couples with or without children.

The archaeological research at the site in 1973 (Jerusalem School of Archaeology, «Bible & Spade Journal») shows that there were no nuclear family dwellings inside the city walls, but that men lived with men, and women and children in separate housing.

As is the case with atomic power, the nuclear family has the potential to be a social force that is constructive or destructive.

Sociologists and anthropologists have spoken of the way in which the nuclear family — the small group of three or four persons — can be vicious because it may (not must) become centered on its own existence and, hence, entirely inward - looking — like a pond with no outlet.

The ideal of the private dwelling and the normativeness of the nuclear family embody, cut off from those outside the immediate household and deliberately limited in the opportunity to interact with others, reflects the substantialist view of reality as composed of discrete, isolated substances.

The small family unit known as a nuclear family today is the typical family type of the modern era in Western cultures.1 During the last two hundred years, identity has been associated more with the family unit than with larger social units like a congregation.

Furthermore, anyone who has studied ancient Near Eastern culture knows that the familial structure we see represented in scripture was nothing like the nuclear family epitomized by the Cleavers, but would rather have included multiple generations and relatives living together in clans, with women working long hours «outside of the home» in the fields, tending sheep, gathering food, trading goods, etc..

I too am tired of selective appeals to «biblical marriage» that tend to glorify the modern nuclear family as the only ideal and render real people with real lives into a mere political / religious «issue,» and I too am reluctant to support an establishment that sends part of its profits to the Family Research Council, an organization that has fed blatant misinformation about homosexuality to Christians for family as the only ideal and render real people with real lives into a mere political / religious «issue,» and I too am reluctant to support an establishment that sends part of its profits to the Family Research Council, an organization that has fed blatant misinformation about homosexuality to Christians for Family Research Council, an organization that has fed blatant misinformation about homosexuality to Christians for years.

This foyer, along with the corridor, is used as a space for social interaction with each other and for entertainment of common visiting friends and relatives Second, there is a rear opening for each unit of the house, which serves as the residence of the respective nuclear family that leads into a common play area.

The house is rectangular, with many well - designed portions to accommodate many nuclear families from the same lineage.

The house is rectangular with many well - designed apartments to accommodate many nuclear families from the same lineage.

With the arrival in history of the Spirit community, the church as body replaced the nuclear family of Adam, Eve, and Seth.

Conservatives in the U.S. who claim to support «family values» have a simple view of family — the 1950s nuclear model where women know their place, barefoot and pregnant in the kitchen — are doing everything to put us back there, including attempts to do away with birth control.

The further you move away from a healthy, white, married nuclear family with a male head of household, etc etc, the more «vulnerable» you become to using formula.

Clearly, the vision we have of the nuclear family, living with a white picket fence somewhere in suburbia, is outdated.

Changes in the structure of the nuclear family, long distances between extended family members and overall social isolation along with short postpartum hospital stays can leave new parents feeling adrift - stressed and unsure.

According to my daughter, I, as her one mother, can't compete with three moms in a nuclear family.

Her 2014 book, «Family Breakdown» received a great deal of criticism due to her claim that there was «undisputed evidence» that sleepovers with those not the child's primary caregiver, including divorced fathers, could cause emotional damage in comparisons to regular nuclear families.

The time married parents spend visiting with friends and relatives outside the nuclear family has declined dramatically: Married fathers spent almost 40 percent less time and married mothers spent almost a third less time socializing in 2000 than they did in 1965, according to Bianchi, Robinson and Milkie.

We should situate fathers» effects in social and individual context, whereby (say) effects may be more pronounced and important in isolated nuclear families in low - fertility high social capital contexts, but less visible in extended families with higher fertility and more substitutable forms of childcare.

Even the right - wing conservative behemoth Focus on the Family, not exactly fans of any kind family other than a nuclear one, has a Blended Families page on its website, where the organization concedes that «with the right resources and the help from God, family, and friends, your step - family can find encouragement and hope.&Family, not exactly fans of any kind family other than a nuclear one, has a Blended Families page on its website, where the organization concedes that «with the right resources and the help from God, family, and friends, your step - family can find encouragement and hope.&family other than a nuclear one, has a Blended Families page on its website, where the organization concedes that «with the right resources and the help from God, family, and friends, your step - family can find encouragement and hope.&family, and friends, your step - family can find encouragement and hope.&family can find encouragement and hope.»

With the joint family system disappearing over the horizon and nuclear families jumping into the fray, young parents get limited help these days in caring for their babies.

And when that fails as it sometimes does with the modern nuclear family, I know where to look for answers to my individual questions.

Nuclear talks might become possible with North Korea in the event Kim Jung - un died or was somehow succeeded by a Gorbachev - like successor who wants to come in from the cold, as it were, and does not have the current family legacy to live up to.

Mr. Bratton said on MSNBC's «Morning Joe» yesterday that he had read Daniel Patrick Moynihan's treatise on race relations, compiled 50 years ago for the Lyndon Johnson administration, and agreed with its conclusions — that the absence nuclear families in black communities contributed greatly to their social and economic struggles.

It has been another big challenge in many ways but with the family support, traditionally as Africans we don't just have the nuclear family, as communities we have the extended families, where we have the aunts, uncles and the cousins and that has made it easier.

«But what did they expect running a candidate from Brooklyn whose views on everything from raising taxes, to forcing hardworking families to pay for campaign ads, to giving billions of dollars to Iran to build nuclear weapons with which to threaten Israel are miles outside the political mainstream?

Researchers from The University of Manchester have taken a major step forward by describing the quantitative modelling of the electronic structure of a family of uranium nitride compounds — a process that could in the future help with nuclear waste recycling technologies.

Small nuclear ribonucleoprotein D3 polypeptide 18kDa (SNRPD3, synonym: SMD) belongs to the small nuclear ribonucleoprotein core protein family, with molecular weights of the D members: D1, 16 kDa; D2, 16.5 kDa and D3 18 kDa.

Assignment of alleles to haplotypes for nearly all the variants on all chromosomes can be performed by genetic analysis of a nuclear family with three or more children.

This phylogeny combines a robust framework for primate families and most genera based on nuclear genes with the expanded taxonomic coverage for genera and species that results from the inclusion of mitochondrial DNA sequences.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transNuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transnuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transNuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transNuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Using nuclear magnetic resonance (NMR) spectroscopy, computer simulations and microscopy, the researchers showed how disease mutations and arginine methylation, a functional modification common to a large family of proteins with low - complexity domains, altered the formation of the liquid droplets and their conversion to solid - like states in disease.

Meaning, it was the one holiday my small nuclear family, with my mother and I at the helm, would host in our home.Our glorious ten - year reign including one disaster... Continue Reading about Sweet Potato Hummus with Tahini and Homemade Za - atar

Where the first movie, which begins with Tyler's character rejecting Speedman's proposal of marriage, subtly positions the masked strangers as a warped reflection of a nuclear family — a man in a suit, a sexualized «pinup girl,» and a cherub - faced baby doll — Prey at Night scores its first killings with Kim Wilde's «Kids in America,» the equivalent of having Bugs Bunny lean into the frame with an arrow - shaped sign reading, «Get it?»