Sentences with phrase «with nucleosome»

Correlation coefficients of total expression levels (log10) with nucleosome formation potential scores in housekeeping (Hkg) and tissue specific genes (Tsg).

«The genome probably stays in a very compact state most of the time, with nucleosomes winding the DNA like a tight spring.

Not exact matches

ASF1 in fact «chaperones» a histone protein, which when coiled in a complex with DNA, forms the basic structural building block of DNA called a nucleosome.

In three out of five people with advanced cancers, the team could use those nucleosome fingerprints to trace circulating DNA to the cancerous tissue.

They found that the addition of a phosphate group to a histone — called H2Av — triggered the entire nucleosome to change shape, exposing previously hidden parts of the nucleosome that began to interact with and activate PARP1.

In this system, the DNA strand, with its genes, is coiled around molecules known as histones, which themselves are assembled into larger entities called nucleosomes.

Nagaki et al. [6] used anti-CenH3 antibodies to immunoprecipitate chromatin (ChIP) comprising DNA bound to CenH3 - containing nucleosomes, confirming that CenH3 is associated with both the CentO repeats and the CRR family of retrotransposons.

The scientists also found out that the type of promoter containing «fragile» nucleosomes is strongly associated with high levels of transcription.

This is done with the help of nucleosomes, basic units made of proteins around which a segment of DNA is wound.

In collaboration with researchers at the Department of Computer Science (UNIGE) and the Swiss Institute of Bioinformatics at EPFL, David Shore's team has undertaken to characterize nucleosomes present in every gene promoter of yeast DNA.

Because this region covers the entire CenHs - binding region (around 750 kb), the authors [6] postulated that CenH3 - containing and dimethyl - K9 H3 - containing nucleosomes are interspersed and that the position of these nucleosomes is dynamic, so that a population of cells may have the same DNA sequence interacting with both types of nucleosome.

There was a striking pattern of such motifs repeated about 10.5 bp downstream of the dominant TSS, suggesting that the nucleosomes have something to do with TSS preference in broad promoters.

We discovered that nucleosomes are arranged into discrete groups, which we called «nucleosome clutches» (as an analogy with egg clutches).

We have demonstrated that the regulatory regions of housekeeping and tissue specific genes have differential chromatin architecture with respect to S / MAR binding, nucleosome positioning potential and repetitive sequences.

Nucleosome remodelers can work if tethered (33), but given the dynamic nature of DNA interactions observed with most transcription factors, we think that the tethering rather increased the local concentration of the factor around the UASGal site.