Among the 50 trials, 30 were primary prevention trials (general populations, smokers and workers exposed to asbestos, patients
with oesophageal dysplasia, male physicians, patients
with non-melanoma skin
cancer, postmenopausal women, patients undergoing chronic haemodialysis, patients
with end stage renal disease, ambulatory elderly women
with vitamin D insufficiency, patients
with chronic renal failure, older people
with femoral neck fractures, patients
with diabetes mellitus, elderly women
with a low serum 25 - hydroxyvitamin D concentration, health professionals, people
with a high fasting plasma total homocysteine concentration, or kidney transplant recipients), and 20 were secondary prevention trials (patients
with cardiovascular disease, coronary heart disease, acute myocardial infarction, unstable angina, transient ischaemic attack, stroke, angiographically proved coronary atherosclerosis, vascular disease, or aortic valve stenosis).