Sentences with phrase «with open chromatin»

It then becomes possible to search for the reduced nucleosomal crosslinking associated with open chromatin and regulatory DNA.

Thus, regional / species specific variation in DNA gain and loss are primarily driven by clade specific / recent transposons interacting with open chromatin either in the male germ line, female germ line or early embryo.

Not exact matches

Having established some understanding of the open chromatin landscape in healthy mice, the researchers now hope to figure out how these relationships change with disease states.

This is consistent with a model in which DNA gain and loss results in turnover or «churning» in regulatory element dense regions of open chromatin, where interruption of regulatory elements is selected against.

Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way — whole - genome profiling of open chromatin — to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome.