Sentences with phrase «with optic nerve»

His sensory preoccupation is in part due to his own experience with an optic nerve disorder in 1994, which left him legally blind.

Not exact matches

Twenty - five had ophthalmologic changes: 18 with intraocular abnormalities, including macular chorioretinal atrophy, mottled retinal pigment epithelium, and optic nerve pallor; seven with strabismus or nystagmus without intraocular abnormalities.

Mice with this eye disease, which damages the optic nerve and causes vision loss, have higher levels of the immune molecule, which accumulates at retinal synapses before the neurons die.

These differentially expressed microRNAs point the way toward finding more genes associated with glaucoma, more clues about how these glaucoma types each go about damaging our optic nerve and potential new points of intervention, the scientists say.

The impulse starts with excitation of the left retina, then travels down the optic nerve to cells in the midbrain and brain stem, which excite neurons near both eyes that cause the pupils to constrict.

The discovery in a rodent model may provide insight into what happens in the visual systems of children born with a condition that prevents the optic nerve from fully developing.

When the UNSW approach was used to assess 13 patients with early glaucoma or optic nerve damage, and 42 people without eye disease, greater vision loss was detected in all patients than using the standard test.

These cells normally don't mingle with neurons from the diencephalon, which gives rise to less advanced structures such as the hypothalamus and optic nerves.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of nerve cell death in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.

«The brain at rest» is actually a hive of activity and what it's doing is trying to sort out information that comes in; I mean this is another, another thing that made Marcus Raichle curious about this, is we know, for instance, that six million bits of data go flowing in through your optic nerve from the environment around you, and then only 10,000 of those bits actually get to the brain's visual processing area and only a few hundred of those are involved in consciousness, and you know, the conscious processing associated with that visual activity.

Nearly 20 percent of children with NF1 develop brain tumors that involve the optic pathway, affecting the nerves that carry vision - related signals from the eye to the brain.

The study shows that the optic nerve could be damaged due to hypoxia without a spike in eye pressure, a finding that could help unravel the details of glaucoma sufferers with normal eye pressure levels.

Consistent with the presence of donor - derived RGCs, YFP - labeled processes were detected exiting the eye at the optic nerve head (Figures 4E, 5B, and S2B).

In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerve.

We have two neurobiologists who are studying retinal ganglion cell and optic nerve biology — and that's me and Andy Huberman — and we also have two optical imaging engineers with very different backgrounds — and that's Vivek Srinivasan and Alf Dubra.

«Until we began to document fossilised brains, nerve cords and optic nerves from the Cambrian, neuroanatomists and palaeontologists did their studies in parallel but didn't really work with each other.

GenSight's treatment is for people with damaged photoreceptor cells but intact ganglion cells; it inserts the gene into the ganglion cells, whose axons form the basis of the optic nerve.

The macula is densely packed with photoreceptor cells called rods and cones that react to light and send electrical nerve impulses to the optic nerve and into the brain.

We're focused on glaucoma and it has to do with a set of very surprising findings in a region that we know is critical for axon loss in glaucoma, which is the optic nerve head.

Replacing rods and cones is challenging, because these cells have to establish connections with nerve fibers that feed signals into the optic nerve, which sends those signals to the brain to interpret.

Structural eye anomalies (in particular, microphthalmia and coloboma), cataracts, intraocular calcifications, and posterior ocular findings have been reported in infants with presumed and laboratory - confirmed prenatal ZIKV infection; however, posterior findings have been the most prevalent.21,25,28,33,35,36,41 - 43 Case series report chorioretinal atrophy, focal pigmentary mottling of the retina, and optic nerve atrophy / anomalies.28, 34,37,41 - 43,55 Series of 20 or more infants with presumed ZIKV - associated microcephaly report ocular findings in 24 % to 55 %.28, 33,42 In one study, testing for ZIKV IgM was performed in 24 of 40 infants (60 %) with microcephaly and the results were positive in the cerebrospinal fluid in 100 % of those tested.42 The proportion of infants with ocular lesions did not differ in those with and without testing.42 In that series, first trimester maternal infection and smaller head circumference significantly correlated with the presence of abnormal ocular findings.42

Second, we discovered that certain genes, namely Ncad expressed in the astrocytes, are important for optic nerve interaction with astrocytes, and for optic nerve regeneration.

Summary: All forms of glaucoma have in common optic nerve degeneration characterized by typical visual field defects, and are usually associated with elevated intraocular pressure, also known as ocular hypertension (OH).

On the surface, the disease appears relatively simple, with high pressure (intra-ocular pressure, or IOP) within the eye associated with the death of cells in the retina and optic nerve dysfunction.

These described early changes in glaucoma associated with the neurochemistry of the retina and optic nerve and the persistence of retinal neurons long after those changes occur.

Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA / 2J mouse model of glaucoma Bosco A., Inman, D.M., Steele, M.R., Wu, G., Soto, I., Marsh - Armstrong, N., Hubbard, W.C., Calkins, D.J., Horner, P.J. & Vetter, M.L. (2008) Investigative Ophthalmology & Visual Science, 49:1437 - 46.

Glial changes in the optic nerve correlate with axonal degeneration in a mouse glaucoma model.

Regular intakes of selenium combined with zinc could help with protecting against glaucoma, which can ultimately result in damage to the optic nerve and blindness.

One study conducted in 2014 concluded that smokers with Graves» disease were more likely to experience rapid eye deterioration, including the development of double vision, the constriction of eye movement, and irreversible optic nerve damage.

Since the optic nerve becomes more fragile as it becomes more damaged, it is much harder to preserve remaining vision in someone with advanced glaucoma vs early glaucoma.

Nutritional optic neuropathy, a damage of the optic nerve with reduction of color vision and visual field defects may be caused by lack of certain vitamins or other nutrients in a chronic alcoholic on a poor diet [19].

In 20th Century Women, a far easier session on the optic nerves, Fanning plays a lustrous, restless, teenage sunflower in Santa Barbara who moves like a pop tune through air, teaches a young lad the proper dude way to smoke and swagger, and mimics the whimpering moans of male lust with fond disdain.

The accident left her with head, neck and back injuries as well as a ruptured optic nerve in her right eye, memory and spatial problems, a speech impediment and chronic headaches.

The back of the eye including the retina and optic nerve are carefully examined with an indirect ophthalmoscope and a variety of special lenses.

Glaucoma is defined as increased pressure within the eye that causes degenerative changes in the optic nerve and retina with subsequent blindness.

When the ophthalmologist views the retina with an instrument called an indirect ophthalmoscope, changes can be seen in the retinal blood vessel pattern, the optic nerve and the tapetum (the reflective portion of the eye that is responsible for «eyeshine»).

The pupillary response comes from the second and third cranial nerve with the nerves actually crossing to the opposite side at the optic chiasm.

Meanwhile, some 30 percent of all babies infected in utero with Zika show eye conditions such as inflammation of the optic nerve, retinal damage or blindness after birth.

The expert believed that the nurse was negligent in part by damaging the woman's left optic nerve by sticking it with the needle.