Sentences with phrase «with osimertinib»

For patients who progress during therapy with osimertinib and a subsequent platinum doublet, there are few definitive clinical data.

The CNS overall response rate (ORR) was 70 % (21 of 30 patients) with osimertinib and 31 % with chemotherapy.

[20] In the phase III AURA3 study, the median CNS PFS was significantly longer with osimertinib than with chemotherapy (11.7 vs 5.6 months; hazard ratio [HR], 0.32; P =.004).

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

Not exact matches

Sarah B. Goldberg, MD, MPH, an assistant professor of medicine at the Yale School of Medicine and Yale Cancer Center, discusses osimertinib (Tagrisso) for the treatment of patients with non — small cell lung cancer.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

[33] It remains unclear how the BBB permeability of AZD3759 will compare with that of osimertinib.