COTC026: Evaluation of a Recombinant, Attenuated Listeria monocytogenes Expressing a Chimeric Human HER2 / neu Protein in
Dogs with Osteosarcoma in the Adjuvant Setting T Fan; $ 585,144; Morris Animal Foundation
Purpose of Study: Standard therapy for dogs
diagnosed with osteosarcoma has long been amputation of the affected limb followed by chemotherapy to prevent the spread of cancer.
Sivacolundhu et al recently published a study (JAVMA July 2013) in which they compared survival times in dogs
with osteosarcoma of the ulna undergoing amputation compared to those who under went a limb sparing surgery known as a partial ulnectomy, in which the lower part of the ulna is removed.
Non-steroidal anti-inflammatory agents (NSAIDs), tramadol, amantadine, and fentanyl are commonly used to combat the debilitating pain
associated with osteosarcoma.
There hasn't been any notable progress in the treatment and survival of human or dog
patients with osteosarcoma in the last 30 years...
Studies have shown that dogs weighing 80 lbs or more are 60 times more likely to become
affected with osteosarcomas than smaller dogs, though the exact causes of this are not currently known.
Starting this spring, we will be participating in a study to evaluate the Canine Osteosarcoma Vaccine, Live Listeria Vector (COV - LLV), a conditionally licensed product for dogs
with osteosarcoma who have undergone amputation and chemotherapy.
The key to success
with osteosarcoma pain control is early intervention and a combination of oral and intravenous drug therapy.
Our dog, Denali, sadly, was diagnosed
recently with osteosarcoma and we made the difficult decision to have our dog's leg amputated and to start chemotherapy to give him the best chance at survival.
Before I delve into the recipe, I wanted to give you an update on the health adventures of Lucy, my big old German Shepherd mix who was diagnosed
with osteosarcoma over two years ago.
Of the dogs
stricken with osteosarcoma, 35 had the cancer in a leg which was subsequently amputated, followed by chemotherapy, which is the standard - of - care treatment; the dogs with elevated total cholesterol had a median survival time of 455 days, more than 200 days greater than the median survival time for dogs with normal cholesterol.
Leeper and collaborators at OSU and Iowa State University compared 64 dogs
with osteosarcoma against two control groups: 30 dogs that had suffered traumatic bone fractures and 31 healthy dogs similar in age and weight to the animals with cancer.
This unusual case introduces the possibility of carrying out a differential
diagnosis with an osteosarcoma and raises the question of the treatment that should be adopted.
The first ever Courage Award went to Jamila Paksima's and Geraldine Moriba's Until 20, the story of Texan James Ragan's quest to live a full and meaningful life despite his terminal
battle with osteosarcoma.
My problem is that my one baby was just diagnosed
with osteosarcoma so I have been label reading like crazy and I have found that 4health has just as much if not more carbs as protein.
To explore this possibility in the new work, the researchers will culture healthy dog
macrophages with osteosarcoma cells to find out whether it leads macrophages to shift gears in the expected way.
Tuohy knew from experience that dogs
with osteosarcoma often die even after the tumor is removed, as the cancer spreads to distant sites.
Murphy and Dr. Downing traveled the road of osteosarcoma treatments and, incredibly, Murphy lived 4 1/2 more
years with osteosarcoma (two separate occurrences).
Veterinary studies report that dogs and
cats with osteosarcoma in the lower jaw have a better prognosis than those with cancer in the upper jaw, living approximately 9 months longer, with 1 - year survival rates ranging from 35 - to 71 %.
This is a study sponsored by the Canine Health Foundation and supported by the IWF to evaluate treatments which may delay the onset of metastatic disease in dogs
with osteosarcoma who have undergone amputation and chemotherapy.
The treatment of choice by veterinarians for most dogs
with osteosarcoma of the leg is amputation of the affected limb, after which most dogs do function quite well.
Bandit was diagnosed
with Osteosarcoma in April 2001 and lived almost six years from her initial diagnosis.
In 2011, I was diagnosed
with Osteosarcoma in my leg,» she explained.
«Scientists test nanoparticle drug delivery in dogs
with osteosarcoma.»
Until 20 — Imagine that at age thirteen you were diagnosed
with osteosarcoma, a rare type of bone cancer, and told that you had no chance of living until twenty.
However, the last few months changed all of that when Cooper was diagnosed
with Osteosarcoma, also known as bone cancer.
Since bone cancer is often spread to the lungs, it is important to have a chest X-ray on any pet diagnosed
with osteosarcoma.
The purpose of this study was to determine if adding the oral drug Rapamycin into the treatment protocol for dogs
with osteosarcoma will be safe and improve efficacy of current standard therapies for osteosarcoma in dogs.
Dogs
with osteosarcoma that has spread to the lungs may also have difficulty breathing or exercise intolerance.
With this form of treatment, survival times of dogs diagnosed
with osteosarcoma is on average about 10 to 12 months with little improvement in survival occurring over the past two decades.
Purpose of Study: This clinical trial evaluated the safety and effectiveness of rapamycin when given to dogs
with osteosarcoma or soft tissue sarcomas.
The most common pain related to cancer is that associated
with osteosarcoma (bone cancer).
Dr. Nicola Mason, recent IWF - sponsored speaker at GLIWA and IWADV, has launched an exciting new study for dogs
with osteosarcoma.
Our beloved Doberman, Jack, was diagnosed
with osteosarcoma in his left leg.
I'm trying to avoid feeding my dog carbs as he was recently diagnosed
with osteosarcoma.