To explore this possibility in the new work, the researchers will culture healthy dog macrophages
with osteosarcoma cells to find out whether it leads macrophages to shift gears in the expected way.
Not exact matches
To address these questions, Dang, Altman, and Hsieh collaborated
with Penn colleague, Aalim Weljie, PhD, research assistant professor of Pharmacology, using an
osteosarcoma cancer
cell line to study the interaction of MYC and metabolism in cancer
cells.
Similar protocols were used for immunoblot analysis of
cell protein extracts from MC3T3 - E1 (mouse preosteoblasts), U-2 OS (human
osteosarcoma), and C2C12 (mouse myoblasts
with osteogenic potential).
Other cancers which may be associated
with vaccine damage include Lymphoma (cancer of the lymph nodes), Leukemia (cancer which affects white blood
cell production), Osteosarcoma (bone cancer), and Mast Cell Tumors (affects mast cells which respond to inflammation / allergens, usually seen as malignant skin tumo
cell production),
Osteosarcoma (bone cancer), and Mast
Cell Tumors (affects mast cells which respond to inflammation / allergens, usually seen as malignant skin tumo
Cell Tumors (affects mast
cells which respond to inflammation / allergens, usually seen as malignant skin tumors).
With osteoblastic
osteosarcoma, tumor
cells manufacture osteoid in abundance.
Below are some of the common specialty areas that we have experience
with: - Infectious diseases: Tick - borne disease (Lyme disease, Ehrlichiosis, Rocky Mountain Spotted Fever, Bartonella), systemic and local bacterial infections, feline and canine viral disease - Hematology: Immune - mediated hemolytic anemia, thrombocytopenia, leukemia, bone marrow diseases - Oncology: Surgical and chemotherapy management, lymphoma, mast
cell tumors, hemangiosarcoma,
osteosarcoma, fibrosarcoma, mammary neoplasia, as well as benign and malignant skin masses such as adenomas and cysts - Urology: Kidney failure, bladder infections, stones / crystals, prostatic disease, pyelonephritis, FLUTD, protein - losing nephropathy, glomerulonephritis - Endocrine: Hormonal diseases such as hyper - and hypothyroidism, diabetes mellitus, cushings disease, addison's disease, endocrine skin disease - Gastroenterology: Chronic vomiting and / or diarrhea, inflammatory bowel disease (IBD), stomach ulcers / gastritis, colitis, pancreatic disorders, liver disease, protein - losing enteropathy - Respiratory disease: Feline asthma, canine chronic bronchitis, upper respiratory viral disease, pleural effusion, laryngeal paralysis - Cardiology: Heart murmurs and arrhythmias, heart failure, heartworm disease, hypertension - Ophthalmology: Gaucoma, cataracts, uveitis, corneal disease, ocular surgery - Allergic disease: Allergic dermatitis, food allergies, flea allergy, and allergic gastrointestinal and respiratory disease
Spaying or neutering in both sexes was significantly associated
with an increased risk for cancers (hemangiosarcoma, hyperadrenocorticism, lymphoma, mast
cell tumor, and
osteosarcoma), ruptured anterior cruciate ligament, and epilepsy.
Many factors are involved in deciding when (or whether) to spay or neuter dogs
with a family history of cancer, especially: Transitional
Cell Carcinoma, Hemangiosarcoma,
Osteosarcoma, Lymphosarcoma, or Prostatic Adenocarcinoma where the risk of cancer in some breeds in limited studies appears to be higher if the dog is spayed or neutered.
The following chart summarizes the evidence associated
with sterilization of dogs as far as predisposition to some common serious cancers according to the recent studies: Type of Cancer Relative Risk Castrated Males Relative Risk Spayed Females
Osteosarcoma (bone cancer) 3.8 3.1 Bladder Cancer 2 - 4 2 - 4 Prostate Cancer 2.4 - 4.3 Splenic hemangiosarcoma 2.2 Mast
Cell tumors 4.1
Studies The Puppy Up Foundation helped fund
with The Broad Institute: Title of Study:
Osteosarcoma Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard Title of Study: Mast
Cell Tumors Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard