Studies suggest that Zika - induced antibody responses may also cross-react
with other flaviviruses, particularly dengue virus.
Not exact matches
In general, examining the potential effects of
other flaviviruses on pregnant women and their developing fetuses is difficult, because outbreaks have been sporadic and less widespread than
with Zika.
The new 3 - D structure, which was obtained using X-ray crystallography and electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of
other flaviviruses — indicating it may interact differently
with the members of an infected person's immune system.
«Researchers are still working to understand precisely how Zika and
other flaviviruses interact
with an infected person's immune system,» she said.
When the assay was run on patients infected
with Zika virus and also on a control group of 540 patients infected by
other flaviviruses or
other viruses, plus healthy donors, the specificity was 95.9 percent.
The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas
with a high level of exposure to Zika virus and
other flaviviruses.
The catch is that, although the antigens bind
with the antibodies according to the lock and key principle, they almost always do so at the same site as all
other flaviviruses.
A near - atomic level map of Zika virus shows its structure to be largely similar to that of dengue virus and
other flaviviruses, but
with a notable difference in one key surface protein, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Given the concerns for immune enhancement
with other similar
flaviviruses, like yellow fever and Japanese encephalitis, ZPIV will be tested in some volunteers who will first be vaccinated against one of these
other flaviviruses.
Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in
other flaviviruses by interfering
with JAK - STAT signaling was present in both the Asian and American sequences from the 2007 - 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.