Not exact matches
THE METHODS Yoshiaki Ohashi, a molecular biologist at the Institute for Advanced Biosciences at Keio University in Japan, chose to work
with hardy Bacillus subtilis, a harmless soil bacterium that forms spores resistant to ultraviolet light, dehydration,
oxygen and nutrient
starvation, and organic solvents.
«In these diseases of mitochondrial dysfunction, in a sense, it's a false
starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough
oxygen,» says Chen, who
with Birsoy, authored a paper in the journal Cell Reports describing this work.
This
oxygen starvation may cause heart cells to die off, worsening heart function and leading to the development of arrhythmias (in which the heart beats too rapidly, too slowly, or
with an irregular rhythm).