Identifying SNPs associated
with particular diseases will enable scientists to predict an individual's likelihood of developing a disease and how the disease runs in families.
Medical foods include those items produced for people
with particular diseases such a phenylketonuria.
Researchers use the Immunochip to investigate DNA samples from people
with a particular disease for linkage disequilibrium (LD) signals that illuminate associations between specific SNPs and the disease.
In general, drug discovery starts
with a particular disease.
In the other, the user asks for a list of the SNPs in a particular region of the genome that correlate best
with a particular disease.
Will the journal's patient reviewers be chosen because of their experience
with a particular disease or skills they have, such as statistical knowledge?
Made up of passionate individuals who voluntarily organize to advocate on behalf of
those with a particular disease or disorder, these «disease advocates» dedicate their lives to bringing positive changes for others, sometimes including their families and themselves.
Prevalence the total number of people in the general population
with a particular disease or condition at any given time.
Specific breeds, like Weimeraners and dachshunds, have shown autoimmune diseases in response to vaccines but, again, these are very rare, are linked to genetic defects, and would be caused by infection
with the particular disease anyway.
«When you actually look at some of the diets experimentally, doing what we call heat maps (DNA or RNA microarray), you will see the enzymes that are turned on, upregulated, and pro-inflammatory initially in a patient
with a particular disease.
Choosing the right life insurance if you have been diagnosed
with a particular disease is not as straightforward as getting life insurance when you are healthy and fit.
Not exact matches
Regarding writing moral codes on «men's hearts,» apparently those
with mental
disease / defects and very young children don't get this
particular attention.
But what struck me
with particular power as I surveyed the Catholic media was that the vast, vast majority of Catholics reported Hitchens»
disease and then,
with transparent sincerity, urged people to pray for him.
His fellow scientists «found
disease fascinating,» but he found
particular people fascinating, especially «how they struggled
with suffering.»
Diagnoses were made on the basis of symptoms, and persons
with a certain cluster of symptoms were given a label in the conviction that a
particular cause might be found for that «
disease.»
The texture, look and taste of gluten - free cakes, in
particular, can take some getting used to on the part of people
with Celiac
disease or those who have embraced a gluten - free diet for other health reasons.
This insight may help us improve vaccine responses in the elderly — a group at
particular risk of
diseases including influenza — by pre-treatment
with anti-inflammatory agents.»
Bryden, who studies combustion — wood, in
particular — got involved
with clean cookstoves in 1998 after learning about the range of the injuries and
diseases stemming from unhealthy cooking practices.
Residents of the United States seem to be at
particular risk,
with each person in the U.S. having about a 4 % chance of developing Alzheimer's
disease, likely due in part to the Western dietary pattern, which tends to include a large amount of meat consumption.
The answer, of course, has a lot to do
with changing perceptions of anxiety, and in
particular our tendency to treat as a
disease what used to be viewed as an innate tendency — or even a moral failing.
This unexpected result suggests that mutations in NPM1 behave as gatekeepers for this cancer; once a mutation in this gene occurs in a cell
with particular previously accumulated pre-leukaemic mutations, the
disease progresses rapidly to become leukemia.
«If we take one of these modified cells and treat it
with a
particular drug, if it doesn't produce light anymore, then this means the drug is a potential treatment for this
disease,» Basu said.
«As
particular strains are associated
with particular habitats, hosts, and
disease symptoms, this work will help us understand why
particular symptoms occur in
particular areas and help us to target control efforts more efficiently,» the authors say.
While several studies in the intervening years have investigated whether
particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated
with the
disease traits that are being studied.
The Overseas Development Agency now has the control of communicable
diseases as one of its priorities for health and population assistance,
with particular attention being given to tuberculosis.
«Overall,» Dr. Schwartz added, «the study underscores the importance of rational drug design, in which drugs are designed to interact
with specific molecular pathways involved in a
particular disease.
Since a controversial study in the 1990s reported that linemen have triple the risk of death from cardiovascular
disease compared
with other players, researchers have paid
particular attention to the health consequences of playing football.
Picking up on recent discoveries that the Notch - modifying enzyme known as Rumi is necessary for animal development and that various mutants of Rumi are linked
with a form of skin hyperpigmentation known as Dowling - Degos
disease (made by scientists at the Baylor College of Medicine and the University of Bonn, Germany), Li's group became focused on this
particular enzyme.
Severe gum
disease is among the most prevalent chronic infection in
particular in African - American populations and is associated
with complex microbial infection in the sub-gingival cavity.
While in some cases, such as cystic fibrosis, having a
particular set of mutations all but guarantees
disease, in many others it correlates only
with an increase in
disease risk.
Interestingly, IBS biologists uncovered additional miRNA end modifications after DROSHA processing, which are expected to be important for the regulation of miRNA biogenesis, whose dysregulation is often associated
with diseases, in
particular with cancer.
In
particular, we were interested in inflammatory bowel
disease which has previously been associated
with higher risk of acquiring this infection and obesity, which has never been examined,» explained corresponding author Nahid Bhadelia, MD, MALD, associate hospital epidemiologist at BMC and assistant professor of medicine at BUSM.
Their findings, reported in Nature Communications, may shed light on human lung
disease, in
particular, the mechanism behind non-familial pulmonary hypertension in patients
with conditions such as emphysema and pulmonary fibrosis.
The investigators pointed out its possible relevance in treating
diseases associated
with a lack of myelin,
with particular interest in multiple sclerosis.
«When we look at grant programs... the key is not the amount of the grant to begin
with, but what we are getting for the taxpayer dollars,» he said, adding that he has supported research into
particular diseases.
The study also analyzed deaths among rheumatoid arthritis patients from a
particular type of cardiovascular
disease — coronary artery
disease — and found those too declined in the 10 years after the patients studied were diagnosed
with rheumatoid arthritis.
When Roswell Park Cancer Institute (RPCI) researchers evaluated the overall and site - specific incidence of cancer among patients registered in the United States Immune Deficiency Network (USIDNET), they found increased cancer incidence rates among patients
with primary immunodeficiency
diseases — and, in
particular, a significant increase in lymphoma cases.
To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a
particular chemical compound might interact
with a biological target of interest — for example, a key protein that might be involved
with a
disease process.
«We might someday be able to manipulate the gut microbiome, and in
particular Enterococcus faecalis, to attenuate alcohol - related liver
disease associated
with gastric acid suppression,» Schnabl said.
«Someday, thanks to studies like this one, we'll get to the top of the mountain and convert this
particular cancer into a chronic
disease — something that patients can live
with, controlled by medication.»
The researchers counted the numbers of a
particular type of immune cell, known as microglia, in the samples and found that these were more numerous in the brains
with Alzheimer's
disease.
The researchers also hope to use gene sequencing technology to compare the brains of those who have died of Alzheimer's
with those of people who died without neurological
diseases, in the hope of finding DNA sequences of
particular microbes in the
diseased brains.
TLC continues to explore solutions to barriers that include addressing regulatory science issues (
with particular focus on repurposing off patent and abandoned drugs for rare and neglected
diseases) and defining exclusivity path (s) to interest future for - profit partners.
The Miriam Hospital provides a broad range of primary, secondary and tertiary medical services to adolescents and adults in 34 medical and surgical specialties and subspecialties,
with particular expertise in cardiology, oncology, orthopedics, gastroenterology, urology, immunology and infectious
diseases.
Then we briefly describe some of the epidemiologic characteristics and recent genomic advances associated
with four
particular infectious
diseases - Ebola, pandemic influenza, hepatitis B and tuberculosis - that have large - scale public health consequences but differ in terms of ease of transmission, chronicity, severity, preventability and treatability, factors which affect a range of ELSI issues.
Darryl De Vivo, M.D., Professor of Neurology at Columbia University Medical Center and a Past - President of the Child Neurology Society, noted, «The SMA Foundation's work on behalf of children
with SMA on all fronts including academic, governmental and biotechnical initiatives has served to heighten awareness of SMA in
particular and Motor Neuron
diseases in general.
Finally, I wanted to study
disease more in depth,
with a
particular focus on human Immunology.
Scientists currently know very little about why these
particular cells within the eye do not survive
with age and cause problems that lead to a
disease called Pigment Dispersion Syndrome (PDS).
Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic
diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver
diseases,
with particular emphasis on different therapeutic modalities for pathway modulation.
Genetic tests, such as those used in this study, can detect common variants of genes associated
with modest alterations in the chances of developing
particular diseases.