Sentences with phrase «with photoreceptor cells»

The macula is densely packed with photoreceptor cells called rods and cones that react to light and send electrical nerve impulses to the optic nerve and into the brain.

«We were focusing on what would happen with the photoreceptor cells, the cells that we knew were dying,» Beltran said.

You can see several of the 760 units that make up the fly's compound eyes, each is filled with photoreceptor cells.

The ragworm has the eyes of an invertebrate and a brain with the photoreceptor cells of a human.

Fresh porcine retinal tissue was dissected, orientated on a 0.45 mm filter with the photoreceptor cell surface uppermost and placed on top of the iPS - RPE monolayer so that outer segments were adjacent to the RPE.

Not exact matches

But is it fair to equate historical constraints with defects in describing how vertebrate photoreceptors are on the back of the «inside - out» retina, shadowed by blood vessels and overlying cells?

Nevertheless, the outcome may pave the way for transplants of stem cell — derived eye cells called photoreceptors, which could dramatically improve vision in people with eye disease if all goes according to plan.

People with retinitis pigmentosa experience a gradual decline in their vision because the eye's photoreceptor cells slowly die off.

The downside is that people with these eye diseases are losing sight in large part because they're losing a different type of eye cell: the photoreceptors that sense light in the retina.

But illumination of the network with a brief flash (10 milliseconds) of blue light causes each of these bacterial photoreceptors to jolt their host cell a bit.

They might also come up with a way to select the right cells out of a mixed population; Anand Swaroop, an ophthalmology researcher at the University of Michigan at Ann Arbor, is working on a way to identify and weed out the photoreceptor cells by focusing on proteins present on cell surfaces.

But when they are nicely aligned with the female, and in the correct position to mate, the photoreceptor cells are totally covered and the response stops, says Arikawa.

In people with RP and AMD, the photoreceptors have been damaged and lost, so the ganglion cells do not receive signals and the brain can not produce an image.

«We demonstrated that in the absence of Numb, photoreceptors are unable to send a molecule essential for vision to the correct compartment, which causes the cells to progressively degenerate and ultimately die,» adds Dr. Ramamurthy, who carried out the project in Dr. Cayouette's laboratory in collaboration with Christine Jolicoeur, research assistant.

In normal mice with working photoreceptors (PR driven), stimulating the retina produces a variety of responses in retinal ganglion cells, the output of the eye.

The researchers injured the mice retinas with a toxin that causes cell death in retinal ganglion cells and interneurons, another type of retinal cell whose job it is to transmit signals from photoreceptors to the brain.

They assessed gene activity at time points known to correspond with key phases of disease: the «induction phase,» the time before the peak level of photoreceptor cell death; the «execution phase,» when the highest rates of photoreceptor cell death occur; and the «chronic phase,» during which photoreceptor cell death continues at somewhat reduced levels.

Human ES cells treated with Noggin, Dickkopf - 1, and Insulin - like Growth Factor - 1 proteins differentiate into functional photoreceptors [5].

0 Research ArticleRETINAL DISEASES Human ESC — derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration Karim Ben M'Barek 1,2,3, Walter Habeler1, 2,3, Alexandra Plancheron1, 2,3,

With age, our eyes accumulate waste in retinal pigment epithelium (RPE), which supports the life and function of photoreceptors (light sensitive cells in the eye); in advanced stages, RPE and photoreceptors die.

Confocal images of P150 dystrophic retina transplanted with hNPCctx — GDNF and double stained with antibodies against human nuclear antigen (red) and either (A) recoverin, a photoreceptor and cone bipolar cell marker (green), or (B) protein kinase Cα (PKCα), a bipolar cell marker (green).

Lanza's team figured out how to coax stem cells taken from human embryos into becoming the RPE cells that die off along with photoreceptors in macular degeneration, and in 2011 the team began injecting these manufactured cells into patients» eyes.

GenSight's treatment is for people with damaged photoreceptor cells but intact ganglion cells; it inserts the gene into the ganglion cells, whose axons form the basis of the optic nerve.

Using the Mfrprd6 model, and others with similar protein localization and phenotypes when mutated, we hope to gain a better understanding of how RPE cells affect photoreceptor development and the process of phagocytosis.

In the past, neural stem and progenitor cells from various sources were introduced into eyes with the thought that they might differentiate and replace photoreceptors lost in retinal disease [13]--[19].

These results correlated with survival of photoreceptors, including cone cells, which are required for optimal daylight vision.

Qualitative examination of the host anatomical response to the presence of hNPCctx or hNPCctx - GDNF revealed substantial preservation of the photoreceptor outer nuclear layer (ONL) overlying all subretinal donor cells (Figure 5E and F), with photoreceptor rescue gradually declining outside the distribution of the transplanted cells (Figure 5E and G).

(B - i) Electron microscopy image of a porcine photoreceptor outer segment (POS) adjacent to an iPS - RPE cell following 3 hours co-culture with a porcine retina explant.

(2006) Müller Cell Activation Correlates with Photoreceptor Loss in DBA / 2 Mice (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1562).

Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.

Importantly, akin to HESC - RPE in vivo, cells at the outside edge of the iPS - RPE cell bolus could phagocytose photoreceptor outer segments from the RCS rat, as indicated by the presence of rhodopsin - positive photoreceptor material within the cellular membrane of iPS - RPE labelled with HSM (Fig. 5E).

Inset shows higher resolution confocal images of photoreceptor cell nuclear layers (DAPI blue) and rhodopsin expression (red) in the dystrophic control (left inset) and dystrophic with iPS - RPE transplant (right inset) RCS rat.

With two - photon fluorescence microscopy Professor Denk could perform two tasks simultaneously: stimulate the photoreceptors of an isolated rabbit retina by moving a light stimulus over it in one direction, and at the same time, record the fluorescence from the individual dendrites of starburst amacrine cells.

Although known to have neuronal cell functions STK38L has not previously been associated with abnormal photoreceptor function; being associated with such a disease in dogs establishes this gene as a potential candidate for similar diseases in other species, including man.

Whereas the genes implicated in early - onset diseases are those necessary for the correct development of photoreceptors the genes associated with later - onset forms of disease are those necessary for the long - term maintenance and function of these cells.

To further examine the morphology of cells and the localization of protein expression within the retina, immunohistochemical staining of both paraffin and OCT retinal sections was performed with the following antibodies (Table S1): human cone arrestin (for cone photoreceptors), rhodopsin (for rod photoreceptors), RPE65 (for the retinal pigment epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes and Müller cells), glutamine synthetase (for Müller cells) and G0alpha (for ON bipolar cells).