Sentences with phrase «with polymorphisms»

You see two positives, which mean that ther — they have uh — their homozygous with these polymorphisms.

Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years

The study found that African Americans with this polymorphism are 30 percent more likely to develop Alzheimer's disease dementia than the African American without the genetic polymorphism.

As it turns out, the effects of this mutation could be offset fairly easily, simply by having people with that polymorphism eat more niacin.

Behavioural scores, however, were not correlated with this polymorphism in our population.

This may be the most useful supplement for those with the polymorphism.

Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and allelic frequencies between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established.

But people with this polymorphism uh — I've seen them wheelchair - bound after being...

Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years

Not exact matches

CONCLUSIONS: The common polymorphisms in MTHFR are not associated with embryo quality or with short - term pregnancy outcomes.

Analyses were used to assess whether these polymorphisms are associated with embryo quality or with ongoing pregnancy or miscarriage rates.

They reveal 341 fixed substitutions (35 nonsynonymous, 173 synonymous, and 133 noncoding) between the 2014 EBOV and all previously published EBOV sequences, with an additional 55 single - nucleotide polymorphisms (SNPs; 15 nonsynonymous, 25 synonymous, and 15 noncoding), fixed within individual patients, within the West African outbreak.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The research looked at more than five million genetic variations, called single nucleotide polymorphisms or SNPs (pronounced «snips»), in each participant in the study and compared the frequency of these SNPs with that of the control subjects.

A polymorphism (rs1051730) in proximity to the cholinergic receptor, nicotinic, alpha 3 (CHRNA3) gene is associated with higher tobacco consumption among smokers and can therefore be used as a genetic proxy for high tobacco consumption.

«Individuals may overeat,» Stice and his colleagues concluded, «to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.»

«What we found is that if people have a specific polymorphism in the BDNF gene, they recovered to a greater extent than those with a different variant of the gene.»

On average, those with the Val / Val polymorphism scored about eight IQ points lower on tests of general intelligence than those with the Val / Met or Met / Met variants, Barbey said.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

The team found that a single polymorphism (a difference in one «letter» of the sequence) in the BDNF gene accounted for significant differences in intelligence among those with similar injuries and comparable intelligence before being injured.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

The result, says Goodfellow, was that «until 1980, the human genome was a markerless desert with the occasional oasis of polymorphism (variation)».

If the polymorphisms in all the peptide sequences are consistent with those of a suspect, then that suspect can be associated with the evidence.

A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent.

To identify new genetic variations associated with different SLE phenotypes, a total of 598,258 different regions on the genome (known as single - nucleotide polymorphisms) were genotyped in a population of 482 Caucasian European SLE patients of Spanish origin recruited from the rheumatology departments of 15 Spanish university hospitals belonging to the IMID Consortium (SLE group).

In order to find out whether this polymorphism is also associated with extreme longevity, Spanish researchers performed an analysis of the frequencies of this polymorphism among centenarians and healthy adults in two independent cohorts, by geographical regions and by ethnic groups.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

Their analysis identified new «extreme longevity - promoting variants» on chromosomes 4 and 7, while also confirming variants (SNPs, or single nucleotide polymorphisms) previously associated with longevity.

Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.

With the advent of more and more sophisticated ways to measure genetic variation and relatedness using molecular markers, such as allozyme polymorphisms and DNA - based markers, not only can individuals be tracked as to their parentage, but changes in allele patterns over time and thus the effects of evolution on populations can be «seen» in the genetic information.

People with the newly identified polymorphism, or form of this gene, appear to be at twice the risk of developing bipolar disorder, though it is not yet clear exactly why, says Blair.

But the exact causes of the vast majority of autism - related disorders remain a mystery: classic genetic studies, which tie the ailment to single nucleotide polymorphisms (SNPs — deletions, additions or substitutions of one unit in the genetic code), have returned a number of different markers with very few well - replicated candidates.

DNA samples were genotyped for single - nucleotide polymorphisms (SNPs), and NAS outcomes were correlated with genotype.

Hill showed a single - nucleotide polymorphism — placed in the genome where a single nucleotide is altered — in this gene is «strongly associated» with elite sprint racing performance.

«These findings suggest that GCLM polymorphisms [gene variants] that affect glutathione production also affect methylmercury retention,» she wrote to me in an e-mail, «and that GSTP1 may play a role in conjugating [chemically joining] methylmercury with glutathione.»

Using these data, we built a genetic model that includes 150 single - nucleotide polymorphisms (SNPs) and found that it could predict EL with 77 % accuracy in an independent set of centenarians and controls.

Indeed, his team found the methylation of CpG sites differed in the discordant pairs with the particular genotypes of 4 polymorphisms.

The effects of the polymorphisms were independent of one another, and both correlated with lowered set points.

They measured metabolites in a few thousand patients with MS, then matched the concentrations of metabolites with single nucleotide polymorphisms (SNPs).

Professor Haase also studies the relevance of genetic polymorphisms of DNA - repair and detoxification genes for AML and MDS, the relevance of iron overload for stem cell functions in MDS, and the establishment of FISH analysis of CD34 + cells from the peripheral blood as a diagnostic tool for screening and monitoring in patients with MDS.

The teams then scanned their respective databases for single - nucleotide polymorphisms — regions where the DNA differs by one base — that were associated with being either taller or shorter than average.

In 2003, Nir Barzilai and Gil Atzmon, who study aging at Albert Einstein College of Medicine in New York, discovered that people with a certain polymorphism of the cholesterol - influencing gene CETP lived longer than those without it (ScienceNOW, October 2003).

Together with this network of genetic mutations and polymorphisms, we must consider the environmental factors to which the individual is exposed, either acutely or chronically.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Large - scale resequencing of the first ESTs and subsequent genotyping of single nucleotide polymorphisms in large populations expanded the available molecular marker resources and provided a basis for examining their association with traits of interest (Eckert et al. 2013).

The study also tested whether 3 single - nucleotide polymorphism multilocus genotype responsiveness patterns or insulin secretion (INS - 30; blood concentration of insulin 30 minutes after a glucose challenge) were associated with weight loss.

Estimating population divergence time and phylogeny from single ‐ nucleotide polymorphisms data with outgroup ascertainment bias.

However, with this technology it is not possible to identify complex structural variants and polymorphisms in repeated or low - complexity regions.

Alu - insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

Polymorphisms observed in the consensus sequences of all individuals were cross-referenced with the MITOMAP database (http://www.mitomap.org/MITOMAP) of reported disease - associated mutations to determine whether any individuals harbored disease - causing mtDNA SNPs.