Not exact matches
The
therapy had an outsized effect in African American men, helping those
with metastatic castrate - resistant
prostate cancer live a median 37.3 months after treatment.
Around four - fifths of
prostate cancer patients have tumors
with lots of PSMA for the
therapy to bind to.
The Bottom Line: The study's researchers believe that the combination of cruciferous vegetables like cauliflower or broccoli
with curcumin can be an effective
therapy to both prevent
prostate cancer altogether and to prevent the spread of
prostate cancer that has already developed.
Disney said the precise binding of Targapremir - 18a to microRNA - 18a means a
cancer drug that follows this strategy would be likely to kill
prostate cancer cells without causing the broader side effects seen
with many other
cancer therapies.
There was also no change based on whether patients had undergone hormone
therapy, a common treatment for
prostate cancer which lowers the male hormone and can be combined
with daily radiation.
Overall, about one - third of men
with prostate cancer receive some type of radiation
therapy.
To be effective and reduce recurrence of
cancer in the
prostate, researchers found that prescribing PARP inhibitors, a drug commonly used in breast
cancer, alongside anti-hormone
therapy treatment may benefit men
with prostate cancer.
During this in depth study, an international team of researchers led by British scientists investigated the impact of anti-hormone
therapy on samples taken from patients
with prostate cancer.
The results from the
Cancer Research UK - funded STAMPEDE trial could change the standard of care for men with prostate cancer, making abiraterone a first - line treatment alongside hormone th
Cancer Research UK - funded STAMPEDE trial could change the standard of care for men
with prostate cancer, making abiraterone a first - line treatment alongside hormone th
cancer, making abiraterone a first - line treatment alongside hormone
therapy.
Radiation
therapy, along
with surgery, hormone
therapy, and active surveillance — known as watchful waiting — has been a mainstay of treatment for
prostate cancer in the United States.
Despite complications sometimes more severe than
with standard radiation
therapy — and costs that are much higher for taxpayers, patients and insurers — proton beam
therapy is heavily marketed for treatment of
prostate cancer.
A new study has identified a group of molecules in
prostate -
cancer cells that doctors might one day use to distinguish which patients should be treated
with radiation
therapy if rising PSA levels indicate their
cancer has recurred after surgical removal of the
prostate.
Using data from a randomized trial of 206 men treated
with either radiation or, radiation and six months of hormonal
therapy, researchers compared early markers of
prostate cancer death to identify men at risk of dying early.
The findings inject hard facts into a debate that has long divided the medical community,
with many radiation oncologists preferring adjuvant
therapy — radiation given soon after
prostate removal to kill off any remaining
cancer cells — and many urologists preferring salvage
therapy — radiation given later, when
prostate - specific antigen tests suggest it's needed.
For men
with intermediate risk
prostate cancer, side effects at two years following radiation
therapy (RT) were comparable for extremely - hypofractionated treatment, which was delivered in seven fractions across two and a half weeks, and conventional treatment of 39 fractions across eight weeks, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
«Depressed men
with prostate cancer are diagnosed
with later stage disease, and get less effective
therapies.»
«We found that the protein isoforms expressed in African Americans
with prostate cancer do not always respond to targeted
therapies, whereas these drugs were found to be effective in European Americans
with prostate cancer and do end up killing off the
cancer,» said Lee.
«A significant number of advanced
prostate cancer patients treated with a chemical castration therapy called androgen deprivation therapy (ADT) experience relapse with relentless progression to lethal metastatic, castration - resistant prostate cancer,» said Ronald DePinho, M.D., professor of Cancer Bi
cancer patients treated
with a chemical castration
therapy called androgen deprivation
therapy (ADT) experience relapse
with relentless progression to lethal metastatic, castration - resistant
prostate cancer,» said Ronald DePinho, M.D., professor of Cancer Bi
cancer,» said Ronald DePinho, M.D., professor of
Cancer Bi
Cancer Biology.
In May 2015, the Moffitt
Cancer Center launched a pilot study to test whether this kind of adaptive - therapy approach might help people with prostate c
Cancer Center launched a pilot study to test whether this kind of adaptive -
therapy approach might help people
with prostate cancercancer.
The finding, reported by a Stand Up to
Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking th
Cancer -
Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking
Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking th
Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men
with metastatic
prostate cancer that no longer responded to standard hormone - blocking
prostate cancer that no longer responded to standard hormone - blocking th
cancer that no longer responded to standard hormone - blocking
therapy.
A large trial showing that men
with newly diagnosed, advanced
prostate cancer lived ten months longer, on average, when they received docetaxel chemotherapy along
with standard hormone
therapy
«This approach may allow tailoring of clinical decisions regarding management of patients
with prostate cancer, thus maximizing the benefit and minimizing the harms of
therapy,» Roy said.
The research team used data from the recently published EORTC 22991 trial to study men
with intermediate - risk
prostate cancer randomized to either radiation
therapy or radiation
therapy and 6 months hormone
therapy.
ADT, which suppresses the production of testosterone by either medical or surgical castration, remains the gold standard for treating advanced
prostate cancer, either alone or
with radiation
therapy.
Of these men, 284 had prescriptions for testosterone replacement
therapy before they were diagnosed
with prostate cancer.
Presenting these results at the 3rd ESTRO Forum in Barcelona, Spain, today (Monday) Professor James Morris, from the Department of Radiation Oncology, Vancouver
Cancer Centre, British Columbia Cancer Agency (BCCA), Vancouver, Canada, will say that the ASCENDE - RT1 trial is the first and only existing trial comparing low - dose - rate prostate brachytherapy (LDR - PB) for the curative treatment of prostate cancer with any other method of radiation therapy del
Cancer Centre, British Columbia
Cancer Agency (BCCA), Vancouver, Canada, will say that the ASCENDE - RT1 trial is the first and only existing trial comparing low - dose - rate prostate brachytherapy (LDR - PB) for the curative treatment of prostate cancer with any other method of radiation therapy del
Cancer Agency (BCCA), Vancouver, Canada, will say that the ASCENDE - RT1 trial is the first and only existing trial comparing low - dose - rate
prostate brachytherapy (LDR - PB) for the curative treatment of
prostate cancer with any other method of radiation therapy del
cancer with any other method of radiation
therapy delivery.
The authors focused on men newly diagnosed
with localized (non-metastatic)
prostate cancer in 1995 - 2011 and treated
with radical prostatectomy, brachytherapy, radiation
therapy, or primary androgen deprivation
therapy (PADT).
All enrolled patients had metastatic
prostate cancer that was worsening despite treatment
with traditional hormone
therapy.
Men
with low levels of the male sex hormone testosterone need not fear that testosterone replacement
therapy will increase their risk of
prostate cancer.
«Surprise: High - dose testosterone
therapy helps some men
with advanced
prostate cancer.»
All had been treated previously
with at least one type of androgen deprivation
therapy and had rising levels of
prostate specific antigen (PSA), a blood marker for
prostate cancer, and radiographic evidence their
cancers were becoming resistant.
Their records were compared
with 192,838 men who did not develop
prostate cancer, of whom 1,378 had used testosterone
therapy.
«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved
prostate cancer patient stratification and targeted
therapy with PARP inhibitors,» notes Johnsen.
In a second
therapy commonly used for men
with prostate cancer, doctors administer the female sex hormone oestrogen, which counteracts the androgens.
Preliminary results of a study of patients
with prostate cancer show that MR tractography may be a reliable quantitative imaging biomarker to assess
prostate cancer treatment response to androgen deprivation and radiation
therapy, according to a team of researchers at Brigham and Women's Hospital and Massachusetts General Hospital in Boston.
Of the nearly 200,000 men diagnosed
with prostate cancer each year in the United States, radiation is a first - line
therapy considered for all but the most advanced disease.
The anxiety and uncertainty that men who choose active surveillance experience when diagnosed
with prostate cancer causes one in four to receive definitive
therapies within one to three years, even when there is no sign of tumor progression.
A new population - based study from The University of Texas Medical Branch at Galveston showed for the first time that exposure to testosterone
therapy over a five - year period was not associated
with an increased risk of aggressive
prostate cancer.
Studies have found that women treated
with radiation
therapy for uterine
cancer, like men who received radiation
therapy for
prostate cancer, have an increased risk of developing bladder
cancer later in life.
Looking ahead, Chen says, «Ga -68-BBN-RGD could play an additive role in staging and detecting
prostate cancer and provide guidance for internal radiation
therapy using the same peptide labeled
with therapeutic radionuclides.»
Since most men
with prostate cancer have indolent (non-aggressive) disease for which conservative
therapy or surveillance would be appropriate treatment, the clinical challenge is not only how to identify those
with prostate cancer, but also how to distinguish those who would benefit from surgical or other aggressive treatment from those who would not.
The majority of men diagnosed
with prostate cancer have low risk disease and face a difficult decision between having the disease managed conservatively through AS or undergoing definitive
therapy.
The research, led by Daniel Krauss, M.D., a radiation oncologist, Beaumont Hospital — Royal Oak, found an association between positive post-radiation
therapy biopsy results and subsequent clinical outcomes in men
with localized
prostate cancer.
This is the first population - based study to compare the follow - up intensity of American men
with prostate cancer who have not undergone aggressive treatment
with those who opted to undergo various forms of aggressive
therapy, such as surgery and radiation.
Management of low risk
prostate cancer with AS appears feasible and safe, yet most men in the U.S.
with low risk disease still undergo definitive
therapies such as radical prostatectomy, which carry the burden of urinary, bowel, and sexual dysfunction that can be avoided, or at the very least postponed,
with management on AS.
«While each of these genes was independently associated
with metastatic
prostate cancer, they have never been studied together in the context of early detection of patients
with prostate cancer that will relapse after localized
therapy with curative intent, «according to the authors, led by Leigh Ellis, PhD, in the Dana - Farber Department of Oncologic Pathology.
Androgen deprivation
therapy (ADT) is a common treatment option for patients
with advanced stage
prostate cancer.
• The incidence of
prostate cancer metastasis was 14.5 percent for patients who received both treatments, compared
with 23 percent for those who had only radiation
therapy.
Many men diagnosed
with prostate cancer receive hormone - blocking
therapy as part of their treatment.
«We urgently need markers to predict which
therapies are going to be effective and which will not be effective in individual patients
with advanced
prostate cancer,» said lead study author Emmanuel Antonarakis, MD, an assistant professor of oncology and urology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, Md. «AR - V7 testing may be extremely valuable in guiding treatment decisions for men with hormone - resistant disease in the near future.&
cancer,» said lead study author Emmanuel Antonarakis, MD, an assistant professor of oncology and urology at the Sidney Kimmel Comprehensive
Cancer Center at Johns Hopkins in Baltimore, Md. «AR - V7 testing may be extremely valuable in guiding treatment decisions for men with hormone - resistant disease in the near future.&
Cancer Center at Johns Hopkins in Baltimore, Md. «AR - V7 testing may be extremely valuable in guiding treatment decisions for men
with hormone - resistant disease in the near future.»