Sentences with phrase «with pyramidal neurons»

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

It receives information via the so - called mossy fibres (MF), which originate in dentate gyrus neurons and, together with pyramidal neurons, form synapses in CA3; in this case MF - CA3 - synapses.

Not exact matches

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

The new research reveals how spatially intermixed pyramidal neurons that were associated with single chandelier cells in the mouse prelimbic cortex segregated into two groups.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

When they mutated neuregulin 3 in neurons that help activate the brain — called pyramidal neurons — the genetically modified mice displayed behavior consistent with schizophrenia.

«What we found at the cellular level correlates with the behaviors we saw in the less - anxious, hyper - active mice, which means having overactive pyramidal neurons with their brakes removed could be contributing to these behaviors,» says Zhu.

Neurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhiNeurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhineurons whilst interneurons are inhibitory.

Ex vivo cortical electroporation (E15 mouse embryos) coupled with organotypic culture for 5 days results in radial migration of EGFP + pyramidal neurons to the cortical plate (CP) and the projection of their axon in the intermediate zone (IZ).

Isolated excitatory spines annotated from a single cortical pyramidal neuron with Vaa3D Synapse Detector program developed in collaboration with the Allen Institute for Brain Science (Unpublished, Dan Iascone)

Synaptic reconstruction of all excitatory inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation (Unpublished, Dan Iascone)

Synaptic reconstruction of all excitatory and inhibitory inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation.

Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism.