Cells in five different organs had died and other cells were expressing proteins associated
with radiation responses.
Not exact matches
In 2007, a helmet covered
with particle counters and an electroencephalograph were sent to the International Space Station to assess how astronaut brain activity changes in real time in
response to
radiation.
Preliminary results of a study of patients
with prostate cancer show that MR tractography may be a reliable quantitative imaging biomarker to assess prostate cancer treatment
response to androgen deprivation and
radiation therapy, according to a team of researchers at Brigham and Women's Hospital and Massachusetts General Hospital in Boston.
Oncologists have long known that in rare cases, after patients receive
radiation therapy to shrink a tumor, the immune system will mount an aggressive
response that wipes out not only the tumor, but metastases throughout the body that hadn't been treated
with the
radiation.
This is the first evidence that the KRAS - variant can predict
response to
radiation, and that individuals
with the KRAS - variant may have an altered immune system.
Wu's team killed the stem cells
with radiation so they wouldn't keep growing and combined them
with a substance that helps trigger an immune
response.
The
response was proportional to
radiation dose, and in the most contaminated regions, the leaf loss was 40 percent less than in control regions in Ukraine
with normal background
radiation levels.
Experiments
with mouse embryo support cells that express mutant DUB or pseudo-DUB proteins show an impaired immune
response when infected
with a virus and impaired DNA damage repair when exposed to ionizing
radiation, further validating the need for complex's correct structure.
By combining local
radiation therapy and anti-cancer vaccines
with checkpoint inhibitors, researchers from the University of Chicago, working
with mice, were able to increase the
response rate for these new immunotherapy...
June 13, 2016
Radiation and vaccination can magnify effects of immunotherapy By combining local
radiation therapy and anti-cancer vaccines
with checkpoint inhibitors, researchers from the University of Chicago, working
with mice, were able to increase the
response rate for these new immunotherapy agents.
Thirty - nine percent of the 31 tumors treated
with 24 gray of
radiation met the criteria for tumor control — a complete or partial
response.
Low - dose chemotherapy,
radiation, or targeted therapies given in combination
with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade
with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell
responses.
At the American Society of Clinical Oncology (ASCO) 2017 Annual Meeting, we presented monotherapy data of nine patients who received G100
with radiation (no pembrolizumab) that showed 100 % DCR rate,
with 44 % of the patients achieved a partial
response (PR) based on WHO criteria, which requires at least a 50 % tumor reduction to qualify as a PR.
Overall, the five - year survival of patients
with a PNET or pineoblastoma is 50 percent to 60 percent, but it is clearly worse among infants or in patients
with incomplete surgical removal and poor
response to
radiation therapy.
Animal research, for example, indicated that supplementing
with probiotics significantly suppressed changes in water loss, skin hydration, and skin thickening in
response to UVB
radiation, and also reduced skin damage.
With radiation, hyperthermia can double the
response to therapy.
Earth's energy balance In
response to a positive radiative forcing F (see Appendix A), such as characterizes the present - day anthropogenic perturbation (Forsteret al., 2007), the planet must increase its net energy loss to space in order to re-establish energy balance (
with net energy loss being the difference between the outgoing long - wave (LW)
radiation and net incoming shortwave (SW)
radiation at the top - of - atmosphere (TOA)-RRB-.
Adding CO2 does not (at least not before the climate
response, which is generally stratospheric cooling and surface and tropospheric warming for increasing greenhouse gases) decrease the
radiation to space in the central portion of the band because at those wavelengths, CO2 is so opaque that much or most
radiation to space is coming from the stratosphere, and adding CO2 increases the heights from which
radiation is able to reach space, and the stratospheric temperatures generally increase
with increasing height.
In the most general sense, upper atmospheric cooling is a
response to a forcing (reduction in net upward LW + SW
radiation) that falls
with height through the upper atmosphere.
Re 9 wili — I know of a paper suggesting, as I recall, that enhanced «backradiation» (downward
radiation reaching the surface emitted by the air / clouds) contributed more to Arctic amplification specifically in the cold part of the year (just to be clear, backradiation should generally increase
with any warming (aside from greenhouse feedbacks) and more so
with a warming due to an increase in the greenhouse effect (including feedbacks like water vapor and, if positive, clouds, though regional changes in water vapor and clouds can go against the global trend); otherwise it was always my understanding that the albedo feedback was key (while sea ice decreases so far have been more a summer phenomenon (when it would be warmer to begin
with), the heat capacity of the sea prevents much temperature
response, but there is a greater build up of heat from the albedo feedback, and this is released in the cold part of the year when ice forms later or would have formed or would have been thicker; the seasonal effect of reduced winter snow cover decreasing at those latitudes which still recieve sunlight in the winter would not be so delayed).
Within a convecting layer, convective fluxes can also be part of the
response, but where convection is bounded within a layer, the layer as a whole must respond
with radiation to radiative forcings and feedbacks.)
«The committee concludes that current scientific evidence is consistent
with the hypothesis that there is a linear, no - threshold dose -
response relationship between exposure to ionizing
radiation and the development of cancer in humans.»
With the impacts of rising temperatures already being felt, and recent IPCC reports drawing into sharper focus the range of impacts expected in the coming decades, solar
radiation management (SRM) is attracting increasing attention as a potentially cheap, fast - acting, albeit temporary
response to some of the dangers of climate change.
In a category like agriculture, the experts looked, for example, at how soybean yields had varied
with temperature in the past, and what a physiological simulation for wheat said about the
response to changes in solar
radiation and soil moisture.
With the surface being more than 70 % water, which evaporates in
response to IR rather than raising its temperature, there is no
radiation - only algebra that can determine temperatures.
While there is evidence of a persistent relationship between periods of aridity during the mid-Holocene and the MCA, as both are associated
with increases in
radiation and cooler SST in the eastern Pacific [64], climate simulations suggest that current forcing by increased GHG may produce an opposite oceanic
response in the future [65].
Section 1 contains five subsections
with results on 27 - day
response of low - latitude ionosphere to solar extreme - ultraviolet (EUV)
radiation,
response to the recurrent geomagnetic storms, long - term trends in the upper atmosphere, latitudinal dependence of total electron content on EUV changes, and statistical analysis of ionospheric behavior during prolonged period of solar activity.
Take a look at Hansen 1993, scaling from
radiation changes in last glacial epoch (plain orbital mechanics affecting irradiation), 3 ± 1 °C, Chylek 2007, differences between the Holocene and the last glacial maximum, 1.3 °C to 2.3 °C, and Bender et al 2010, looking at the
response from Mount Pinatubo and the volcanic aerosols,
with current temperature ranges, 1.7 to 4.1 °C.
While actual scientists are trying to piece together every little part of an otherwise almost un-piecable long term chaotic and variable system in
response now to a massive increase in net lower atmospheric energy absorption and re
radiation, Curry is busy — much like most of the comments on this site most of the time — trying to come up
with or re-post every possible argument under the sun to all but argue against the basic concept that radically altering the atmosphere on a multi million year basis is going to affect the net energy balance of earth, which over time is going to translate into a very different climate (and ocean level) than the one we've comfortably come to rely on.
In contrast to this, the calculated TOA outgoing
radiation fluxes from 11 atmospheric models forced by the observed SST are less than the zero feedback
response, consistent
with the positive feedbacks that characterize these models.
GMT drops initially at glacial inception in
response to decreased summer
radiation at high northern latitudes that would have led to equatorward extension of sea ice and snow cover
with associated cooling from increased albedo.
This study therefore suggests the rapid
response to CO2 forcing is (apart from a possible small negative
response from LW water vapour) essentially confined to cloud fraction changes affecting SW
radiation, and further that significant feedbacks
with temperature occur in all cloud components (including this one), and indeed in all other classically understood «feedbacks».
The pattern of SW cloud fraction
response to SST changes differs quite markedly to this,
with large positive
radiation responses originating in the upper troposphere, positive contributions in the lowest levels and patterns of positive / negative contributions in mid latitude low levels.
So the point is this — even if Hypothesis C is correct, there may still be a difference between the
response of the ocean temperatures below the surface — for back
radiation compared
with solar
radiation.
They come up
with all kinds of hypothetical feedback mechanisms involving more natural aerosol emissions in
response to global warming: Dimethylsulfide from marine phytoplankton (although a very intriguing possibility, this has never been confirmed to be a significant feedback mechanism, and there is ample evidence to the contrary, which is omitted from the report), biological aerosols (idem), carbonyl sulfide (idem), nitrous oxide (idem), and iodocompounds (idem), about which they write the following: «Iodocompounds — created by marine algae — function as cloud condensation nuclei, which help create new clouds that reflect more incoming solar
radiation back to space and thereby cool the planet.»
[
Response: It's true that most of Angstrom's paper (which is available from the link we gave in Part I) dealt
with absorption of solar
radiation.
The microstructural properties of the anterior thalamic
radiation and IFOF have also been associated
with individual differences in empathic abilities (experiencing emotion in
response to the perceived emotions of others).