Sentences with phrase «with real uncertainty»

Honest scientists would thus call for more data collection when faced with a real uncertainty, of course — which McIntyre would never dream of doing, except as a stalling tactic.

Not exact matches

«There are real shortcomings in how American politics are covered, including pervasive groupthink among media elites, an unhealthy obsession with the insider's view of politics, a lack of analytical rigor, a failure to appreciate uncertainty, a sluggishness to self - correct when new evidence contradicts pre-existing beliefs, and a narrow viewpoint that lacks perspective.»

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

The legal tussle may well divide the on - demand economy into two camps: the fundamentally sound companies — the ones that can figure out how to compete on any sort of playing field, as long as it's level, because they're selling a real innovation — and the companies that exist only because the current haze of legal and regulatory uncertainty paired with free - flowing venture capital has permitted them to flourish.

Yet real success is built upon making peace with uncertainty, turning the unknown into a field of creative possibilities.»

With the recent changes to the U.S.'s immigration policies, we know this is a time of real uncertainty for many of our colleagues around the world.

For example, the Brazilian real depreciated amidst uncertainty associated with the presidential election and a general weak economic outlook.

«What's really driving the real estate market is our sense of where we're going and the uncertainty at the time with the new administration in Washington, and all this talk.

With the Brexit vote is complete, and the divorce proceedings of the UK from the European Union is now afoot, with considerable uncertainty and no real precedent, the future implications for UK's property markets are significWith the Brexit vote is complete, and the divorce proceedings of the UK from the European Union is now afoot, with considerable uncertainty and no real precedent, the future implications for UK's property markets are significwith considerable uncertainty and no real precedent, the future implications for UK's property markets are significant.

They are evolving in line with shifting demographics and provide diversification and stability of income returns compared to mainstream real estate, which is becoming more expensive and susceptible to economic uncertainty.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The 8 month uncertainty about Sanchez and Ozil and the swap no money deal for Man United reject Mkhitaryan have only compounded endemic issues like injuries, and the feeling that Arsenal abides overpaid under performing players with no real demands to win the big trophies.

GOAL claim that Morata has already agreed personal terms with Milan, who finished sixth in Serie A this season, but there remains some uncertainty around the transfer fee, with Milan keen to pay $ 60m and Real hoping for closer to $ 70m.

Liverpool, Manchester United and Chelsea have all been tipped with moves for Isco amid uncertainty over the playmaker's Real Madrid future.

ALBANY — The uncertainty of who will be on the Working Families Party line for governor this fall is causing «real tension» between the party and the unions affiliated with...

The city's real estate stakeholders got a fresh dose of uncertainty on Wednesday following the four - member Independent Democratic Conference's announcement that it would end its alliance with state Senate Republicans, which has paved the way for pro-business legislation since 2012.

Combining these results with the results from the current work, Jones says, «creates a nuanced picture of how eminence is protective when there is uncertainty, but when there's a real scandal, being eminent doesn't help.»

Is the uncertainty that comes with the quantum wave function real or a mathematical quirk?

In an apparent vacuum, this alignment is driven by virtual particles that share many properties with their «real» counterparts but are constantly popping in and out of existence, thanks to quantum uncertainty.

And here, there's an even deeper uncertainty: We don't know if supersymmetry has anything to do with the real world.

Unlike adolescents» choices in the context of full information, their behavior under ambiguity and uncertainty also correlated with their self - reported risk - taking in the real world.

To calm your uncertainty, we found the people who know best: researchers, scientists, and Ph.D's, to provide you with the real story — and why creatine is better (and safer) than you might think.

Andrew T. Fiore, a data scientist at Facebook and a former visiting assistant professor at Michigan State University, said that unlike laboratory studies, «online dating provides an ecologically valid or true - to - life context for examining the risks, uncertainties and rewards of initiating real relationships with real people at an unprecedented scale.»

«Online dating provides an ecologically valid or true - to - life context for examining the risks, uncertainties and rewards of initiating real relationships with real people at an unprecedented scale,» he told the Times.

Written in the first - person narrative of Colton's father, Todd, with New York Times best - selling author Lynn Vincent, «Heaven Is for Real» walks readers through the revelation of Colton's trip, his parent's initial uncertainties and the lessons learned by such a small child.

«Implementing a new real estate tax with just eight days» notice and no consultation with the professionals who serve home buyers and sellers needlessly injects uncertainty into the market,» stated Morrison.

With the market uncertainty about the ultimate losses in structured securities backed by the residential real estate mortgages, and in light of the dramatic drop in the value of shares of publicly - traded FGIs, the FGIs face a difficult market for new capital.

For example, real estate in North America looks like a good total inflation hedge (beta about +2), but with a huge range of uncertainty (from about +6 to -2) just for that one time and place.

These risks include, among others, general economic conditions, local real estate conditions, tenant financial health, the availability of capital to finance planned growth, continued volatility and uncertainty in the credit markets and broader financial markets, property acquisitions and the timing of these acquisitions, charges for property impairments, and the outcome of legal proceedings to which the company is a party, as described in the company's filings with the Securities and Exchange Commission.

Wells Fargo organizes closing guarantee loan plans that go far in easing uncertainties in the purchase of housing real estate for borrowers with poor credit histories.

Where there is real uncertainty is with Aeroplan, which needs to move fast to secure new partnerships (don't expect another national airline to launch and become the saviour) so that consumers will still want to earn Aeroplan points — and have something travel related to spend them on.

There are various things you can do to try to handle the uncertainty, which I know is not easy, especially if this is your first real experience with volatility.

With fully 2/3 of Americans being pet owners, the need to provide pet food to pet owners experiencing economic uncertainty is real and immediate.

These games remove the worst of the uncertainty, helplessness, ambiguity, and consequences for failure that come with those real world jobs and turn them into game systems that are interesting and fun to interact with.

But instead he triumphed through all the uncertainty and doubt regarding the series as a future development, finally allowing «11 on 11 online play with 22 real humans around the globe,» just a dream at the time.

It's the people who like curiosity - driven research in climate dynamics who have the real incentive to argue that there's a lot of uncertainty, because uncertainty allows people with strong intellectual curiosity to make the case that there's at least some tangential benefit of their work to the climate sensitivity problem.

Regarding the Hockey Stick of IPCC 2001 evidence now indicates, in my view, that an IPCC Lead Author working with a small cohort of scientists, misrepresented the temperature record of the past 1000 years by (a) promoting his own result as the best estimate, (b) neglecting studies that contradicted his, and (c) amputating another's result so as to eliminate conflicting data and limit any serious attempt to expose the real uncertainties of these data.

(2007) • Contribution of Renewables to Energy Security (2007) • Modelling Investment Risks and Uncertainties with Real Options Approach (2007) • Financing Energy Efficient Homes Existing Policy Responses to Financial Barriers (2007) • CO2 Allowance and Electricity Price Interaction - Impact on Industry's Electricity Purchasing Strategies in Europe (2007) • CO2 Capture Ready Plants (2007) • Fuel - Efficient Road Vehicle Non-Engine Components (2007) • Impact of Climate Change Policy Uncertainty on Power Generation Investments (2006) • Raising the Profile of Energy Efficiency in China — Case Study of Standby Power Efficiency (2006) • Barriers to the Diffusion of Solar Thermal Technologies (2006) • Barriers to Technology Diffusion: The Case of Compact Fluorescent Lamps (2006) • Certainty versus Ambition — Economic Efficiency in Mitigating Climate Change (2006) • Sectoral Crediting Mechanisms for Greenhouse Gas Mitigation: Institutional and Operational Issues (2006) • Sectoral Approaches to GHG Mitigation: Scenarios for Integration (2006) • Energy Efficiency in the Refurbishment of High - Rise Residential Buildings (2006) • Can Energy - Efficient Electrical Appliances Be Considered «Environmental Goods»?

Far better this than running a dozen GCMs with funamentally different assumptions about climate feedbacks, plotting them on a graph and claiming that as a measure of the uncertainty in the behaviour of the real climate.

This mantra refers to a complex non-linear dynamic system with annual variation in forcing greater than 80Wm - 2 (20Wm - 2 for the guys that can only think in terms of averages) repeated by «scientists» so inept at thermodynamics and statistics that they confuse confidence intervals based on temperature anomalies with actually uncertainty of energy flow based on T ^ 4 relationship of the real T not the imaginary T anomaly.

With the far more common and widely accepted method, decision analysis, the policy analysts need the projected costs and benefits, the probabilities that the costs and benefits will be achieved given the real world constraints, and the uncertainties on the inputs.

«Uncertainty» is tacked onto a number without explanation that it is not meant as accuracy as used with real measuring instruments.

Instead, we find that «uncertainty» is actually being used to express the statistical PRECISION of the computer modeling output sets with respect to each other, not with respect to the real world.

Uncertainty is not used in a way that equates to accuracy with respect to the real world.

Complexity of the climate system and uncertainty surrounding input data preclude extremely accurate predictions, but they are not incompatible with an ability to approximate real world outcomes within a range narrow enough to justify future planning on the basis of reasonable probabilities.

You have to remember that the 5 year forecast is derived from a large number of individual runs each with slightly different starting conditions matching the range of the observational uncertainty in the real starting conditions.

While a set of equations, known as the Liouville equations, exists to determine the initial uncertainty in the model initialization, the equations are too complex to run in real - time, even with the use of supercomputers.

There's a real debate that needs to be had on the values, economics, and politics associated with the risks of climate change; lets have that debate in the context of a rational backdrop of what we understand about the climate system, along with the uncertainties and unknowns.

Assuming that climate change and other deep uncertainties can not be eliminated over the short term (and probably even over the longer term), it then summarizes existing decision - making methodologies that are able to deal with climate - related uncertainty, namely cost - benefit analysis under uncertainty, cost - benefit analysis with real options, robust decision making, and climate informed decision analysis.

Because of the many uncertainties involved, any estimate of climate sensitivity comes with a range, a lower and upper limit within which the real value could reasonably lie.