Sentences with phrase «with rearrangements»

We suggest that North Atlantic millennial - scale climate variability is associated with rearrangements of the atmospheric circulation with far - reaching influences on the climate.»

Patients greeted her father with a nod as he passed or with some rearrangement of their posture.

According to him, space and time imply movement and the change of light: «As light moves across the object, the forms and the color appear to change with the rearrangement of the shadows.

Not exact matches

His sermons are often little more than rearrangements of biblical texts with a few connectives thrown in!

Specifically, in consultation with Ruth C. Hopewell, his executor, I decided to limit my revisions to rearrangement of the text and editing for clarity and consistency.

Richard Bell, The Qur» an, translated with a critical rearrangement of the Surabs.

This reconstruction16 gives the fullest possible endorsement to the text as it stands, and achieves the logically anticipated sequence of speeches with minimal rearrangement.

All that our fiddling with the criteria achieves is a rearrangement of the castes.

This guilt is so strong, so clear, and so deeply sunk in their central self - consciousness that one knows with an immediate impatience that no diminution of hours or other rearrangements of outer life can have decisive effect.

We are urged on every side to bring our speech into conformity with the common language of our world, to avoid expressions that do not «communicate,» to be careful lest we suggest to the mind other than a rearrangement of its present content.

The final result was the rejection within mainstream culture of biblical literalism with its repudiation of history, geology, and the scientific method, and an acceptance of the contributions of science, of evolution and Freudian psychology, of a «higher criticism» of the Bible, of the move from an agrarian economy to an industrial economy and its need for high technology, and of a rearrangement of political views to accommodate social planning and reform which became known in the churches as the Social Gospel.

With this kind of physical rearrangement must come a reengagement with what I call focal things and practiWith this kind of physical rearrangement must come a reengagement with what I call focal things and practiwith what I call focal things and practices.

2 Morgan (EEV) contrasted «emergents» with «resultants — the latter indeed being new qualities explained on the basis of evolutionary continuity (a novel rearrangement of previously - existing components).

With a little rearrangement it looks a bit like a few of the early 40s psalms.

New parents also undergo a rearrangement of their social life, including how they interact with extended family and friends.

Poorer quality embryos and those with chaotic, abnormal chromosome rearrangements are unable to do this properly and stop dividing.

The committee rearrangement was in line with Saraki's promise before the Senate went on recess that the committees would reshuffled to ensure effective performance.

The lesions associated with many of the bithorax complex mutants have been identified, and most are due to DNA rearrangements.

The work «helps us to understand how chromosomes have changed over time, which chromosome rearrangements may have led to the formation of new species, and what might be driving chromosomal rearrangements,» says Janine Deakin, a geneticist at the University of Canberra who was not involved with the work.

«Rare genetic cause of peritoneal mesothelioma points to targeted therapy: Genetic rearrangement in the ALK gene found in young women with mesothelioma may be targetable with FDA - approved drugs.»

In his own practice, Chirieac is routinely examining for the presence of ALK rearrangements for patients with mesothelioma and educating his residents about this new finding.

They identified ALK - positive mesotheliomas by immunohistochemistry; confirmed with fluorescence in situ hybridization; and performed targeted next - generation sequencing of tumor DNA and RNA to get a full picture of the exact genetic rearrangement underpinning the disease.

Now, through an unexpected observation and a meticulous study of patients seen at Brigham and Women's Hospital, BWH investigators have added a fourth cause to the list: a genetic rearrangement in the ALK gene, observed in three patients with peritoneal mesothelioma.

Patients with ALK rearrangements do not respond to EGFR - TKIs, but are sensitive to other targeted therapies (such as ceretinib).

All patients had both CTCs with ALK rearrangements and CTCs with ALK copy number gain before treatment and at two months.

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

Ceritinib provides longer progression - free survival than chemotherapy in crizotinib - pre-treated patients with non-small-cell lung cancer harbouring an ALK rearrangement, according to results of the phase III ASCEND - 5 study presented at the ESMO 2016 Congress in Copenhagen.

«In order to understand how a system chooses its rearrangement scenario,» said Douglas Durian, professor of physics and astronomy at the University of Pennsylvania, «we must make connection with the underlying microscopic structure.

Although «genomic rearrangements have been associated with autism for awhile,» finding more of the novel changes is «quite exciting for the field,» says Simon Gregory, an associate professor of medical genetics at Duke University's Center for Human Genetics, who was not involved in the study.

Pavel Pevzner and Glenn Tesler compared the just - sequenced mouse genome with its human counterpart and analyzed where rearrangements, a common type of genetic mutation, occur.

Testing for the EGFR mutation and ALK rearrangements and the use of targeted therapies have given lung cancer patients the chance for survival, along with improved quality of life and time with loved ones.

Most forms of cancer resemble evolution happening on an accelerated timescale, with a sudden explosion of genetic rearrangements taking place in the cells.

Structure determination of a cocrystal with TFIIS reveals a rearrangement whereby cleavage of the RNA may take place.

«In mice infected with the malaria parasite, these so - called chromosomal rearrangements occur very frequently in GC lymphocytes,» says Robbiani, «and at least some of the changes are due to AID.»

They then looked for DNA breaks associated with receptor gene rearrangement by using a version of the polymerase chain reaction that amplifies broken DNA.

One likely explanation is that genes that have evolved separately, even without any chromosomal rearrangement, produce proteins incompatible with the proteins of other species, he says.

For example, previous research by geneticist Stephen Oliver of the University of Manchester, U.K., and colleagues suggested that chromosomal flip - flopping in yeast was not the primary means of speciation, since past rearrangements did not appear to correspond with the branching off of new species.

The fragment forms a «micronucleus» with its own membrane and becomes prone to extensive rearrangements of its genetic material, which can then be reincorporated into chromosomes during the next cell division.

How these self - promoting genes jump to these prime locations remains a mystery, but the researchers believe it may have to do with the DNA's three - dimensional structure in particular areas that allows for genetic rearrangement when the genome is being copied or when certain genes are active.

Pairwise alignments were calculated using Shuffle - LAGAN (window size, 400 bp; step size 40 bp; translated anchoring), a glocal alignment algorithm that is able to calculate optimal alignments by using both local alignments and global maps of sequence rearrangements (e.g. duplications of the fiber gene in adenovirus genomes with 2 fibers)[57].

We excluded large genomic rearrangements from this analysis as those mutations span multiple bins and also undertook a subset analysis with and without missense mutations.

With this approach the authors report a number of unique RP mutations, a previously undescribed disease gene called NEK2 that involves the retinal photoreceptors, and structural DNA rearrangements originating in introns.

This is likely true for two reasons; 1) there would not have been much time for a large number of chromosomal rearrangements to occur between these early ancestral human and mouse genomes, 2) and that since divergence with the boreoeutherian ancestor the human genome has undergone only a small number of chromosomal rearrangements meaning that many human telomeric regions are ancestral [58, 73].

AID - deficient Bcl - xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig / Myc chromosomal rearrangements.

Uncovering a complex rearrangement of PML - RARA in a patient with PML - like disease, for example, led to a targeted therapy (ATRA) and complete remission for the patient.

The LymphoTrack TRB Assay completes the comprehensive menu of Invivoscribe LymphoTrack Clonality Assays which enable rapid clonal rearrangement identification with the unparalleled accuracy and sensitivity of next generation sequencing (NGS).

With our NGS - based assays, the gene rearrangement status of several million lymphocytes in blood, bone marrow, or tissue samples can be both identified and characterized.

Duration of Symptoms Does Not Correlate with Results of T - cell Gene Rearrangement Studies in Patients Evaluated for Cutaneous T - Cell Lymphoma.

The LymphoTrack ® Dx TRB Assay for the Illumina MiSeq ® is an in vitro diagnostic product intended for next - generation sequencing (NGS) based determination of the frequency distribution of TRB gene rearrangements in patients suspected with having lymphoproliferative disease.

Whole genome sequencing has now revealed that males with alternative reproductive strategies carry a chromosomal rearrangement that has been maintained as a balanced genetic polymorphism for about 4 million years.