Sentences with phrase «with related genes»

Pollinger et al., [44] identified a 40 Mb selective sweep on CFA11 associated with black coat color in Large Munsterlander and a 10 MB region on CFA3 in Dachshund containing FGFR3, which is responsible for achondroplasia in humans and presumably linked with related genes responsible for canine chondrodysplasia.

In the dominant deafness model, gene therapy with a related gene, TMC2, was successful at the cellular and brain level, and partially successful at restoring actual hearing in the startle test.

Not exact matches

One of Pitt's pileup of controversies involved a meeting with Gene O» Kelly, then CEO of KPMG, when that firm was under investigation related to the Xerox accounting scandal.

The company's technologies provide customers with powerful new ways to examine disease - related genes.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

The doc - umented gene flow with Neanderthals indicates they were related enough not to reject, at either the molecular or organismal scale, mating with H. sapien.

Two newly discovered members of the mimivirus family, both called tupanviruses and both with tails, have the most complete set of genes related to assembling proteins yet seen in viruses (SN Online: 2/27/18).

He arrived in 2012 and now oversees a team of eight scientists (including two Ph.D. s and one M.D.) who support researchers with resources and tools related to RNA interference (RNAi) and CRISPR gene - editing technologies.

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

First, they did a quantitative analysis of the anatomy of related fossils and extant animals to generate a hypothesis about the transition; next, they searched for possible shifts in gene expression that correlated with the transition.

They are also studying whether the nanoparticles can be used with the CRISPR / Cas9 gene - editing technique to treat genetic lesions related to retinal degenerative diseases.

When the team induced expression of the corresponding gene in the leaves of two other plant species (one closely related to S. lycopersicum and the other more distantly related), both plants reacted to presence of the C. reflexa peptide with increased production of ethylene, and exhibited increased resistance to C. reflexa infestation.

To link, at a molecular level, a gene variant with biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present study, is therefore something of a breakthrough.

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

The results show — for the first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in genes that code for energy - related processes like cell division and biosynthesis of amino acids than are seen in their shallower counterparts.

However, last August a team headed by plant ecologist Allison Snow at Ohio State University demonstrated that this same gene might produce some very tough weeds: She found that wild sunflowers crossed with Bt sunflowers produced offspring that suffered significantly less insect - related damage and produced 50 percent more seeds than control plants without the gene.

The researchers assessed LPLD - related acute abdominal events that required hospital care in a small group of patients treated with a single dose of the gene therapy product Glybera ®.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

The second gene, TNFRSF6B, encodes a receptor related to those that bind tumor necrosis factor (TNF)-- a key chemical signal for triggering inflammation in IBD as well as in patients with other autoimmune disorders such as rheumatoid arthritis and psoriasis.

«In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs.»

At first, it was difficult to imagine how pathogens can acquire genes from Actinobacteria, because they are so different and not at all related with each other.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

«Brain genes related to innovation revealed in birds: Glutamate brain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.»

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

«The other major part of the story is that in mycorrhizal lineages there is a huge turnover in genes that are upregulated in the symbiosis - many of these have no homologs in even closely related species, suggesting that the evolution of the symbiosis is associated with massive genetic innovation.»

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

«We were surprised that the heritability of depressive symptoms in twins with very short sleep was nearly twice the heritability in twins sleeping normal amounts of time,» said principal investigator Dr. Nathaniel Watson, associate professor of neurology and co-director of the University of Washington Medicine Sleep Center in Seattle, Wash. «Both short and excessively long sleep durations appear to activate genes related to depressive symptoms,» added Watson, who also serves on the board of directors of the American Academy of Sleep Medicine.

Even distantly related bacteria can swap genes with one another using a variety of techniques, from direct cell - to - cell transfer, called conjugation, to transformation, in which a bacterium releases snippets of DNA that other bacteria pick up and use.

And 40 genes involved in these nine schizophrenia - related pathways also differed much more between chimps and humans than genes associated with the other 12.

The researchers from Queen Mary University of London sequenced the HAS2 gene in thirteen similar or related mammals, combining the data with DNA sequences extracted from 57 published genomes representing all the major mammal groups.

With the state - of - the - art DNA sequencing technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related genes.

No one knows but Eric Keverne, of the University of Cambridge, in England, who has done much of the work on brain - related imprinted genes, continues to wrestle with these intriguing findings, trying to fit them into the framework of intersexual warfare.

Castoe and his team used a similar genomic approach to understand gene flow in two closely related species of western rattlesnakes with an intertwined genetic history.

Angela Christiano, a skin researcher at Columbia University who has discovered genes related to hair loss, recently brainstormed potential solutions to the problem with her colleagues.

With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.

In a population with so few individuals, an unhealthy mutant gene will more often find itself paired with the same mutant gene in an offspring because the parents are related and of similar genetic makeup.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

In 2010 biologist Valerie Hu of the George Washington University Medical Center and her colleagues found that brains of people with autism have low levels of a protein produced by a gene called retinoic acid — related orphan receptor - alpha (RORA).

«To fully understand the loss of olfactory receptor genes in the ground tit, further comparisons need to be made with genomes of closely related species inhabiting lower altitudes.»

So his team sifted through genetic information from 45,000 microbes, flagging groups of genes with unknown functions that were located near known defense - related genes.

While her postdoc work is not related directly to cystinosis, she hopes there are aspects of the gene therapy and cellular therapy skills she is learning at Scripps that will be transferable to her work with the disease.

But associating gene information with related genomic results is a constant challenge, especially when the data are appearing faster than we can manage them.

Changes in BabA binding properties, through mutation and recombination with BabA - related genes, evolve due to differences between individual hosts and changes in gastric acidity over time.

«The statistics show that carrying this gene, combined with being infected with hepatitis A, conveys an enormous protection against asthma, allergies, and related diseases,» Umetsu says.

It is not known whether tryptophan byproducts from L. reuteri induce the cells to develop in people as they do in mice, but defects in genes related to tryptophan have been found in people with inflammatory bowel disease.

Insofar, the results are also relevant for humans: 85 % of the long - lived rodents» genes are identical to human DNA, but in contrast to humans that are rather prone to illness, long - lived rodents have a very low risk to come down with age - related diseases.

They did, however, find copies of genes related to CDR1, CDR2, and few others that encode other transporters associated with drug resistance — although the way they function in C. krusei is unknown.

Together with research into other immune - related genes in diseases such as Alzheimer's, the idea that immune processes are involved in some psychiatric phenotypes is looking ever more solid.

If Hamilton's hypothesis was correct, «successful» virtual robots were likely to be those that were closely related and shared food with each other; that would help to ensure that at least one of them — and some of the genes of both — would make it to the next round.

Just under half of the Bajau carry the version of this gene that is associated with larger spleen, compared with 6 percent of the Saluan and 3 percent of Han Chinese (a population chosen for comparison because they are not closely related to either group), he says.