Sentences with phrase «with rodent studies»

The results, combined with rodent studies, raise the possibility of a preliminary — but as yet unestablished — link between the abundance of P. copri and the risk of rheumatoid arthritis.

Not exact matches

Start with the studies done by Jane Goodall, and then continue with a HUGE variety of other animal studies that PROVE animals have morals, they use tools, build societies and cultures, have their own languages (such as the prarie dogs... simple little rodents right?

With the support of her rodent - tolerant family, she studied the effects of varying thyroid hormone levels on the physical characteristics of a small rat colony she housed in her living room.

Chipmunks and other rodents» light stripes are painted with a recycled brush, a new study suggests.

In a similar heart study, rodents dosed with phytic acid registered a drop in serum cholesterol of 32 percent and a decrease in triglycerides of 64 percent.

Furthermore, animal studies suggest that taste buds produce hormones that are important for glucose metabolism and that, in rodents, taste buds decrease in number with age.

Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain.

The study was done with rodent malaria, but the researchers, at Pennsylvania State University in University Park, expect the pattern to apply to human malaria and possibly to other mosquito - borne diseases such as dengue fever and West Nile virus.

And although many of the initial animal studies used mRNAs with pseudouridine, Moderna's new chemistry was already starting to outperform that first generation in rodent studies.

After starting with these human observations, Palmer's team is now studying the same delay discounting - related genetic traits in rodent models.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

During studies with mice, he concluded that female rodents were more anxious when their hormone levels mirrored those of premenstrual women.

Dr Kristensen recommends that an inter-disciplinary approach be taken to address this, «by combining epidemiological data from human studies with more experimental research on models, such as rodents, it may be possible to firmly establish this link and determine how it happens, so that pregnant women in pain can be successfully treated, without risk to their unborn children.»

In these reviewed studies, rodents given paracetamol during pregnancy, at doses equivalent to those that a pregnant woman may take for pain relief, produced female offspring with fewer eggs.

Research in rodents, along with imaging studies in new mothers, are finding areas of the brain that could be involved in postpartum depression.

Recent studies have shown that endorphin blockers do lessen the activation of reward circuits in humans and rodents that are presented with appetizing food — the subjects eat less.

Changes in muscle repair with aging were determined by injecting the old mice and young mice (neither group exercised) with snake venom commonly used to induce muscle injury in rodent studies.

Researchers assumed that African rodents must have their own menagerie of hantaviruses and that these might infect humans as well — an idea supported by studies that showed that some Africans carry antibodies that cross-react with Eurasian hantaviruses.

Yet when Jennifer Lavers, a marine biologist at the Institute for Marine and Antarctic Studies in Tasmania, ventured there two years ago to study invasive rodent - eradication efforts, she found the once pristine UNESCO World Heritage Site inundated with trash — 17.6 metric tons of it, she conservatively estimates — pretty much all of it plastic.

In December 2009, Summers became the first patient enrolled in a clinical trial of a method pioneered in studies with rodents and cats by Edgerton and others.

«Our findings are clinically relevant as they identify a novel addiction target in rodents, along with parallel supporting evidence from brain imaging studies in human addicts,» explains Andon Placzek, lead author of the nicotine study.

But studies with rodents, Miller says, indicate that if her aging could be retarded, she'd live to be 115.

Through these endeavors and my current research program, I am actively engaged in fostering collaborations with academic, non-profit and industry partners to conduct large - scale rodent behavioral evaluations and preclinical studies.

This webinar will discuss the promise CRISPR / Cas9 has for rodent studies along with strategies for developing better models to understand and treat human disease.

Scientists have long known that restricting calories can fend off physiological signs of aging, with studies in fruit flies, roundworms, rodents and even people showing that chronically slashing intake by about a third can...

For their new study, scientists compared ancient mouse teeth with those of modern rodents that hang out near people who are only semi-settled.

Here we present data from studies profiling cytokines in human and rodent samples using our standard - throughput FirePlex immunoassays, and introduce the simplified workflow of our high - throughput FirePlex immunoassays, with data demonstrating the performance for quantifying key cytokines in multiplex.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Last April, at a conference resort next to the Golden Gate Bridge, 52 scientists from around the world spent three days doing case studies on: 1) wildlife diseases with vectors such as mosquitoes, 2) wildlife diseases without vectors, such as chytrid fungus in amphibians, 3) destructive island invasives such as rodents and ants.

These findings are consistent with our previous studies of transplanting specific subtypes of rodent glial precursor derived astrocytes into sites of spinal cord injury, and indicate a remarkable conservation from rat to human of functional differences between astrocyte subtypes.

In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly from the immature CNS [49]--[53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated from precursor cells in vitro in order to optimize benefit.

During this time, I have been actively engaged in clinical studies of participants that have been diagnosed with glaucoma or high - risk ocular hypertension, as well as in laboratory - based studies on experimental glaucoma models in rodents and non-human primates.

CELPHEDIA networks aims to develop transverse inter-species approaches (rodents with the mouse as a leader, non-human primates and non mammalians including aquatic vertebrates), at the level of both the technology and the study of human diseases, but also to harmonise scientific protocols and processes.

In addition, the group has studied venation of tree leaves as a model system of a complex biological network with interesting topological and geometrical features, and has recently created methods to section whole rodent livers and reconstruct their three - dimensional vascular structure in unprecedented detail.

I encourage you to read the full CRUK Science Update Blog post «High - impact science: Hedgehogs, flies and skin cancer — the story of vismodegib», it's an excellent example of how research on flies, rodents and a range of other organisms combined with studies of cancer genetics in humans to enabled the development of an innovative therapy.

Although discrepancies exist in the literature, most in vivo studies with rodents strongly support the role of some (poly) phenol classes, particularly flavan -3-ols and resveratrol, in promoting energy expenditure.

Some human data currently are available and most are consistent with studies in rodents.

Functional studies in rodent models suggest that OPHN1 linked ID is a consequence of abnormal synaptic transmission and shares common pathophysiological mechanisms with other cognitive disorders.

Finally, combining the results of PET imaging of declines in these different neuromodulator systems with behavioral studies in patients with Parkinson's disease and rodents with experimental damage to those systems helps us understand how they contribute to both cognitive deficits and the risk for falls.

In a study published in the Journal of Agriculture and Food Chemistry, mice fed a high - fat diet along with acetic acid — vinegar's key component — developed up to 10 % less body fat than control rodents.

Current evidence from studies in rodents and humans suggests that IER is capable of promoting weight - loss and / or favourably influencing an array of cardiometabolic health indices, with equal or greater efficacy than conventional continuous ER approaches.

After three weeks of IER however, a separate study noted a reduction in fat - mass, which suggests that unlike in the rodent studies mentioned previously, humans may be unable to fully compensate for energy deficits incurred on fast days with increasing durations.

I remember seeing some rodent study that found, with low enough protein intake, they could eat way above the normal calorie intake without gaining fat.

Accumulating data suggests that IER may also activate hormesis, and there has been some suggestion that it is thestress associated with fasting, or the alternating periods of anabolism and catabolism, rather than an overall ER is responsible.15, 105 IER (100 % ER / alternate days) in rodent studies has been shown to up - regulate the expression ofanti - oxidative 20, 105, anti-apoptotic 20, 21 and pro-angiogenic 21 factors.

Current evidence from studies in rodents and humans demonstrates that IER (50 - 100 % ER on restricted days) is capable of promoting weight - loss and / or favourably influencing an array of cardiometabolic health indices, with equal or greater efficacy than CER.

There are multitudinous studies where high fat diets with 40 - 60 % calories from fat are used to induce cardiometabolic diseases in rodents, with 10 - 13 % fat diets used as a «healthy» control.

Rodent studies have provided compelling insights; however, they have countless shortcomings as a reflection of human microbiota, human dietary patterns, and the ultimate intertwining of these variables with complex mental health disorders.

And I bet obesity researchers who typically work with rodents would believe it, too, since peanut butter is often used in these studies as a high - reward, obesogenic comfort food that rats and mice will readily and consistently overeat.

In rodent studies, TRF with an early eating period (eTRF) mitigates weight gain by increasing energy expenditure (EE).

In a later study, they applied some Alzheimer's inflicted mice with 500 mg of caffeine (where do they find these poor rodents?).