Research shows that older fathers are more likely to have children
with schizophrenia and autism, but the team doesn't know if the mutations they observed are linked to either condition.
The molecules produced during gluten digestion include exorphins, which have also been found in the spinal fluid of people
with schizophrenia and autism, and are thought to worsen the symptoms of these neurological diseases.
Last week at the 23rd International Conference on Subterranean Biology in Fayetteville, Arkansas, he demonstrated how drugs that help people
with schizophrenia and autism similarly affect the fish.
Not exact matches
A2 Corp claimed the beta casein A1 found in most cows» milk sold in New Zealand had been linked
with the development of coronary heart disease, childhood diabetes
and also implicated in
autism and schizophrenia.
There are also some controlled trials associating wheat gluten
with various disorders of the brain, including
schizophrenia,
autism and cerebellar ataxia (45, 46, 47).
The Muotri lab uses induced pluripotent stem cells from patients
with autism and schizophrenia to look for biomarkers of these conditions.
«The interaction between the two types of neurons could also help explain the presence of seizures in patients
with schizophrenia, dementia
and some forms of
autism.»
Altered patterns of variability were observed in the brain's default network
with schizophrenia,
autism and Attention Deficit Hyperactivity Disorder (ADHD) patients.
Scientists used CRISPR - Cas9 to shed light on why people
with 15q13.3 microdeletion syndrome — a rare human genetic disorder — are more likely to develop brain disorders like
autism spectrum disorder, epilepsy
and schizophrenia (Karun K. Singh, abstract 103.05, see attached summary).
Working
with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000
schizophrenia and autism patients
and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.
Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI,
and like humans
with autism or
schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.
At Caltech, developmental neurobiologist Paul Patterson found he could induce the core symptoms of
autism and schizophrenia in mice by giving their mothers the flu during pregnancy, or by arousing their immune systems in utero
with an injection of foreign RNA.
The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people
with a diagnosis of
schizophrenia and also found that some of the genes identified as increasing risk for
schizophrenia have previously been associated
with other neurodevelopmental disorders, including intellectual disability
and autism spectrum disorders.
The results fit
with other evidence that
autism may be caused by overdevelopment of specific brain regions
and schizophrenia by underdevelopment, says Crespi.
Disorders associated
with faulty neuronal circuits include epilepsy,
autism,
schizophrenia, mental retardation
and spasticity
and movement disorders, among others.
Future studies about romantic attachment will focus on using the findings from research such as Young's
and Diamond's to develop new treatments for grief associated
with partner separation or loss
and for disorders that involve social deficits, such as
schizophrenia and autism.
Christianson said his team uses neuroscience techniques «to investigate the biological basis for social cognition
with the hope that we can better understand
and treat people
with conditions marked by aberrant social cognition such as
autism or
schizophrenia.»
Similarly, many problems related to attention — including attention - deficit hyperactivity disorder, drug addiction, some forms of
autism,
and schizophrenia — have been associated
with a dopamine deficit.
This helps us in everyday life, but it also holds great potential when trying to understand why people
with autism and schizophrenia have difficulties
with social interaction.
A new study from Aarhus University, Denmark, helps us understand why people
with autism and schizophrenia have difficulties
with social interaction.
They contend that mental illness can be thought of as occupying a spectrum,
with autism at one end
and schizophrenia, bipolar disorder
and depression at the other.
On one hand, a number of recently identified genetic contributors to
schizophrenia and autism interact closely
with the WNT system.
And people who should have been diagnosed with autism were often misdiagnosed with schizophrenia or other mental conditions and institutionaliz
And people who should have been diagnosed
with autism were often misdiagnosed
with schizophrenia or other mental conditions
and institutionaliz
and institutionalized.
To grasp the implications, Stefánsson's team compared the whole - genome sequences of 78 Icelandic people diagnosed
with autism or
schizophrenia with the sequences of their fathers
and mothers.
In their new paper, Cheyette
and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain
and interacts
with DISC1, a gene implicated in
schizophrenia, depression, bipolar disorder,
and autism spectrum disorders.
Statistically significant hazard ratios for specific groups of psychiatric disorders were found for
schizophrenia and psychoses (1.27, 1.16 - 1.38), affective disorders (1.32, 1.25 - 1.39), anxiety
and other neurotic disorders (1.37, 1.32 - 1.42), mental
and behavioural syndromes including eating disorders (1.13, 1.04 - 1.24), mental retardation (1.28, 1.17 - 1.40), mental development disorders including
autism spectrum disorders (1.22, 1.16 - 1.28),
and behavioural
and emotional disorders including attention deficit hyperactivity disorder (ADHD)(1.40, 1.34 - 1.46), when compared
with rates in naturally conceived children.
The same change is seen in patients
with neuropsychiatric conditions such as
schizophrenia, Down's syndrome,
and autism,
and in people
with poor impulse control.
Mutations seen in people
with autism,
schizophrenia,
and bipolar disorder cause loss of synapses in mice
First, an analysis of genomic data from 6,000 patients
with autism spectrum disorders, 1,000 patients
with bipolar disorder,
and 2,500 patients
with schizophrenia by co-first author Pierre - Marie Martin, PhD, a postdoctoral researcher in Cheyette's lab, revealed that disruptive mutations in the main neuronal form of DIXDC1 were present about 80 percent more often in psychiatric patients (0.9 percent had mutations) compared to healthy controls (0.5 percent had mutations).
Ultimately, they diagnosed him
with autism and psychosis, which, Foss - Feig says, was probably due to
schizophrenia.
Sasson
and Pinkham also observed that a higher IQ predicts better social skills among people
with schizophrenia but not among those
with autism.
Looking at these results, along
with Pinkham
and Sasson's findings, Eack says, «There may be certain things that are particularly prominent to focus on in
schizophrenia —
and other things that may be less prominent or more prominent to focus on in
autism.
Sasson was studying developmental psychology,
with a focus on
autism,
and Pinkham was interested in
schizophrenia and clinical psychology.
They expected to see more overlap between ADHD
and autism, but the modest
schizophrenia -
autism connection is consistent
with other emerging evidence.
Two years later, the team received funding for a larger - scale investigation, evaluating a whole suite of social skills in 54 individuals
with schizophrenia, 54
with autism and average intelligence quotients (IQ)
and 56 typical adults.
This idea of finding shared neural processes presupposes that the same problems explain the social difficulties seen in people
with autism and those
with schizophrenia — an idea that Sasson
and Pinkham's work has brought into question.
Psychologists Noah Sasson
and Amy Pinkham, who are conducting the trial, have pored over hours of tape featuring scenes like this one, evaluating how people
with autism or
schizophrenia approach everyday interactions.
A 2012 review from Stanford researchers analyzed over 50 studies that used neuroimaging - that is, MRI, fMRI, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI),
and anything else that takes before -
and - after pictures of the brain - to examine the brains of kids
with a variety of mental illnesses: anorexia, ADHD,
autism, bipolar disorder, depression, OCD,
and schizophrenia.
The two diagnoses started to take on separate lives,
with age of diagnosis — around 4 years in
autism and between 16
and 30 in
schizophrenia — becoming an important differentiator.
Then she learned that people
with 22q duplication — abnormal repetition, or duplication, of genetic material in chromosome 22 — had learning delays
and sometimes
autism, but a lower risk for
schizophrenia than that found in the general population.
In a 2007 study, Sasson
and his collaborators showed 30 individuals — 10
with autism, 10
with schizophrenia and 10 who are typical — a series of movie stills in which people express fear, anger, sadness, surprise or happiness.
For that boy, her colleagues recommended medication commonly prescribed for
schizophrenia and behavioral therapy used to treat
autism, along
with guidance on both conditions for his parents
and teachers.
Eack, Minshew
and their colleagues asked people
with either
schizophrenia or
autism to imagine someone else's visual perspective.
Another study, which Sasson
and Pinkham published last year, found that when people
with schizophrenia do take note of faces, they are more prone than people
with autism or typical people to jump to the wrong conclusions if the expressions are hard to decipher.
He details the distinct strengths of savants
and prodigies
and of those
with autism and schizophrenia.
Then Seung could see if the patterns of connections are different in the brains of healthy people
and those
with autism,
schizophrenia,
and other disorders.
The study may explain, among other things, how the mother's infection
with the cytomegalovirus (CMV) during pregnancy, which affects her own
and her fetus's immune system, increases the risk that her offspring will develop
autism or
schizophrenia, sometimes years later.
Dysfunction of synapses is associated
with a host of neuropsychiatric disorders such as epilepsy, addiction,
schizophrenia and autism.
With their new method, Zhang
and her colleagues hope to soon begin looking at the unique properties of human astrocyte cells in a range of disease types, including Alzheimer's, ALS, stroke, injury,
autism,
and schizophrenia.
In humans, the cerebellum's extensive connectivity
with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception
and cognition,
with recent work linking cerebellar dysfunction to such complex diseases as
schizophrenia and autism.