Sentences with phrase «with scrapie»

To test their findings, the researchers inoculated transgenic mice with prions from sheep with scrapie, another prion disease causing neurological damage, and determined that these prions have dramatically different biological properties.

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

Scientists generally assume that BSE arose in cattle whose feed was enriched with a high - protein supplement: sheep parts, unfortunately infected with scrapie.

But, making assumptions based on past experience with scrapie, the Southwood committee decided that it was unlikely that BSE could be passed to humans.

Prion specialist Moira Bruce of the Institute for Animal Health's Neuropathogenesis Unit in Edinburgh says that sheep experimentally infected with BSE become ill about as fast as sheep naturally infected with scrapie.

Moreover, mice infected with scrapie progressed more quickly to disease.

Not exact matches

The idea is that scrapie prions might somehow interfere with the infectivity of BSE prions.

With the scale of the nvCJD threat to public health still unclear, scientists have been busy investigating the relationship between the strains of prions blamed for neurodegenerative illnesses, including the presumed connection between BSE and scrapie.

Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.

While the origins of BSE remain obscure, one possibility is that the cattle developed the disease by being fed meat and bone meal contaminated with prions from the sheep with the disease, scrapie.