Sentences with phrase «with skeletal muscle»

Such augmentation correlated with elevated serum testosterone levels and corresponded to significant increases in myofibrillar protein.3 Testosterone is the primary hormone that interacts with skeletal muscle tissue, and when elevated leads to increased muscle growth.

Skeletal muscle mass and / or CSA are known to be positively correlated with skeletal muscle strength (35, 36).

This brown fat also shares origins with skeletal muscle.

Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin -, amino acid - and exercise - induced signalling

This includes the fat contained within the liver, but as we shall see later, also the fat contained with the skeletal muscles and pancreas.

Not exact matches

Cytokinetics is collaborating with Astellas Pharma Inc. («Astellas») to develop reldesemtiv (CK - 2127107), a next - generation fast skeletal muscle troponin activator (FSTA).

A review investigated the evidence on protein, resistance exercise and their combined effects on skeletal muscle hypertrophy and found that supplementing with either whey protein alone or with carbohydrate after exercise, and possibly before and during, improved muscle hypertrophy.

Meta - analyses have shown that altitude training OR hypoxic training affects RBC, Hb, Hct, EPO, and VO2max when compared with sea - level training... also shown in some studies are capillary area, skeletal muscle mitochondria density.

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

One issue is that higher doses of statins are associated with myositis (muscle inflammation) and rhabdomyolysis (destruction of skeletal muscle) so it would be essential to carefully monitor these side effects, he noted.

Researchers who previously showed that a gene therapy treatment could save the lives of dogs with a deadly disease called myotubular myopathy — a type of muscular dystrophy that affects the skeletal muscles — have found that the therapy is long - lasting.

Given that inactivity and hypoxia are frequently associated with several important cardiovascular and respiratory diseases there is a suggestion that for skeletal muscle, inactivity is worse compared to hypoxia.

Bottom row: skeletal muscle with restored dystrophin after application of the CRISPR / Cas9 platform.

The results obtained on skeletal muscles, moreover, will have to be interpreted in conjunction with those deriving from other studies of the PlanHab project, dealing with the cardiovascular, respiratory, immune and central nervous systems and metabolism.»

About six in 100,000 babies are born with centronuclear myopathy, which weakens skeletal muscles so severely that children have trouble eating and breathing and often die before age 18.

These patients are usually treated with NSAIDs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination.

«We learned a lot with this animal model, but perhaps the most important finding was what we observed when we transplanted skeletal muscle stem cells,» said Kyba.

Scientists at the University of Southampton have shown that higher muscle mass is strongly linked with healthier bone development in children.Researchers also found no relationship between fat mass and bone development, indicating it is not an important factor in childhood skeletal strength.

Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries.

Sarcopenia is a disease associated with the aging process, resulting in loss of skeletal muscle mass and muscle strength and / or function in the elderly.

Glass's team next used a combination of chemicals to injure a mouse's skeletal muscles, and then regularly injected the animal with three times as much GDF11 as Wagers and her team had used.

Using new technologies, including XROMM (x-ray reconstruction of moving morphology), which combines 3D skeletal models with x-ray video, as well as micromeasurements of muscle movement taken with thin - walled metal tubes that are visible with x-ray fluoroscope, the team reveals just how stretchy those tendons are.

In this study researchers used a genetically modified mouse with high levels of PGC - 1a1 in skeletal muscle that shows many characteristics of well - trained muscles (even without exercising).

The researchers discovered that the genes with the DUF1220 domains are expressed in the heart, spleen, skeletal muscle, and small intestine, and are particularly active in the brain's neocortex.

Furthermore, we analyzed sections from tissues directly associated with glucose homeostasis (liver and skeletal muscle), stained with hematoxylin and eosin, over a range of 250 µm.

These findings in murine muscle, coupled with a significant association between a SNP in exon 3 of the IL15RA gene and human endurance athletes, support our hypothesis whereby IL - 15Rα has a role in defining the phenotype of fast skeletal muscles.

Skeletal muscle tissue also produces increased amounts of iNOS and TNF - α in obese compared with lean rodents and humans (21, 71).

SNPs in the human IL15 and IL15RA genes have been associated with responses of skeletal muscle to resistance training (17), baseline measures of skeletal muscle and bone (16), and markers of the metabolic syndrome (16), suggesting a role for these genes in skeletal muscle.

I have presented data showing that FLRG, like follistatin, can promote muscle growth when expressed as a transgene in skeletal muscle and that both of these molecules appear to act by blocking not only myostatin but also other ligands with similar activity to myostatin.

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU - acquired weakness.

Thyroid hormone receptors are down - regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

Defined basic principles of how skeletal and cardiac muscle cells adapt to changing physiological demands associated with exercise or disease states.

One of these tissue types, specifically the mesoderm, develops into skeletal muscle cells (along with other cell types, including cardiac muscle, kidney cells, red blood cells, and smooth muscle).

Abstract Type 1 ryanodine receptor (RyR1) is preferentially expressed in skeletal muscle, and mutations in the gene have been associated with malignant hyperthermia, a pharmacogenetic disease, and with several congenital myopathies, including central core disease, multiminicore disease, centronuclear myopathy, congenital fibre type disproportion.

He added that this finding also means that muscular dystrophy (MD) researchers who are attempting to develop genetic therapies must target defective smooth muscle as well as the malfunctioning skeletal muscle most often associated with the crippling effects of the disease.

IGF prevents frailty by increasing skeletal muscle mass (sarcopenia), sex drive (infertility), brain thymus (immunosenescence, centenarians maintain a strong immune system), skeletal bone mineralization and marrow stem cell formation (osteoporosis and immune system by bone marrow immune cells working in tandem with thymus and lymphs nodes), I understand that diabetes, an accelerated aging phenotype, is insulin IGF and blood glucose driven.

(6) This is consistent with the deleterious effect of such cells on tissue function, and with the researchers» conclusion that «the observed improvements in skeletal muscle and fat of late - life treated 10 - month - old BubR1H / H; INK - ATTAC - 5 mice reflect attenuated progression of age - related declines rather than a reversal of ageing».

However, Setd7 expression increased with the progression of myogenesis in vitro indicating the potential importance of this event for skeletal muscle development and regeneration in vivo.

Manno, Catherine et al. «AAV - Mediated Factor IX Gene Transfer to Skeletal Muscle in Patients with Severe Hemophilia B.» Blood.

Furthermore, the model has been used to study the molecular background for the impaired glucose transport and glycogen synthesis associated with insulin resistance in skeletal muscles.

The candidate must have an experience working in the biology and physiology of skeletal muscle, with a reference to in vitro / ex vivo muscle cell contraction.

Recently, skeletal muscle has been recognized as an endocrine tissue with the capacity to secrete cytokines and growth factors, known as myokines, which can act on distant tissues.

Ongoing T2D research activities at CRGGH include 1) whole - exome sequencing of African families with at least four affected members (data generation is complete and analysis is ongoing), 2) GWAS of 1,200 cases and 1,200 controls from West Africa using the new and more efficient African - centric Affymetrix Axiom genome - wide array with more than 2 million markers, and 3) whole genome expression analysis on skeletal muscle obtained from biopsy from 45 subjects (expression QTL (eQTL) studies on the dataset are complete).

We applied our technique to the study of molecular motors, using myosin II from fast skeletal muscle, and to protein - DNA interaction, for the lactose repressor (LacI) interaction with DNA.

Human satellite cell cultures display numerous features of mature skeletal muscles (1) and have been used for studies of muscle metabolism in cultures established from patients with type 2 diabetes and healthy control subjects (1 — 5,8,9,21,22).

Large, age - related deletions in mtDNA are likely responsible for the systemic rise in oxidative stress with aging, and for localized but terrible pathologies of skeletal muscle and substantia nigra dopaminergic neurons in aging bodies.

The decline in skeletal muscle function associated with human ageing can be ascribed to an increasing number of mutations in satellite cells — the resident stem cells of skeletal muscle.

We also identified the mutation for a new form of rostrocaudal muscular dystrophy that affects skeletal muscle tissues with an unusual front - to - back severity of symptoms.

Human skeletal muscles have an epigenetic memory of earlier encounters with growth, according to a Keele University - led study.