Sentences with phrase «with slow progression»

With a slow progression on the difficulty level for these puzzles you are eased into the mechanics as you gear up for the puzzles at the end which will really make your brain hurt if you don't approach them correctly.

Degenerative Myelopathy has a slow, insidious onset with a slow progression of weakness.

Data show that infected children with slow progression of disease and Elite controllers develop neutralizing antibody and ADCC.

Not exact matches

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

Even then it was a slow progression that started with fried rice.

If you look at the players who have been not performing as well as they should then you look at the signings then you will see Arsenal FC slowly rebuilding, I would like it done faster like a lot of Arsenal fans but slow progression is happening... As I said, I am not happy with how slow it is but Arsenal FC could do more if they had the people in who could focus on those aspects.

Behind him in the pecking order, Martin Kelly has shown excellent promise as a backup — even being linked with a first England call up — and to sign a 29 year - old would surely slow his progression.

These factors for me have resulted in a slow progression to this period where we have dropped away further in the league and have key players with 1 year left seemingly holding us over a barrel and also it seems far from convinced of where the club is going.

«The search for treatments that slow the progression of neurodegenerative diseases has gradually shifted from ameliorating symptoms to finding agents that reduce the progression of the disease,» said Gary Lynch, PhD, who studies neurodegeneration at the University of California, Irvine, and was not involved with this study.

Ozanimod significantly slowed the loss of brain volume compared with IFN — a hallmark of the disease that causes brain atrophy, disease progression and cognitive impairment.

In patients with chronic kidney disease who are not on dialysis, ACEIs and ARBs slow the progression of diabetic nephropathy and reduce cardiovascular risk.

«This study also highlights the potential use of this anti-estrogen or miRNA in patients with recurrent prostate cancer, for whom there is no treatment, and raises the possibility of using anti-estrogen or miRNA treatments in preventing or slowing progression for primary prostate cancer.»

According to a 2011 study published in the New England Journal of Medicine, sirolimus in selected patients slowed the progression of the disease and was associated with a reduction in symptoms and improved quality of life.

In a group of animals in which tiny implanted windows allowed direct imaging of brain tissue, the progression of A-beta plaque deposition was fastest in animals receiving APOE4 and slowest, sometimes even appearing to regress, in mice injected with APOE2.

«There could be a significant increase in prostate cancer death rates if more people are diagnosed with metastatic disease, because treatments can only slow progression, it's not curable,» Schaeffer said.

If men present with metastatic prostate cancer, treatments are not curative and only slow disease progression.

«The cause of the disease is unknown and there is no cure, but its progression can be slowed with eye drops or surgery to lower pressure in the eye.

Their study of fecal samples from 105 patients treated with immune checkpoint blockade indicates that certain characteristics of patients» microbiomes correlate with slower disease progression while other qualities are associated with rapid worsening of the disease.

«We still need more studies to determine if there are other treatments that can be used to slow the progression of kidney disease specifically in individuals with sickle cell trait.»

Because most cases of Parkinson's disease appear to be at least partially caused by environmental factors such as pesticide exposure, these findings support the approach that targeting α - synuclein could slow or stop the progression of Parkinson's in most people with the disease, said study lead author Jeff Bronstein, a professor of neurology and director of movement disorders at the David Geffen School of Medicine at UCLA.

The team also showed that there are three distinct phases of MAO activity that change along with Alzheimer's progression: a slow initiation stage, a subsequent aggressive stage and finally a saturation stage.

The Penn team also found that patients with this genetic variation had a slower rate of Parkinson's disease progression, and lower amounts of alpha - synuclein in the brain.

In the drug trial, researchers have shown that treatment with a type of sugar molecule called cyclodextrin slows progression of the disease.

In addition to demonstrating that disease progression slowed with cyclodextrin, Ory and his colleagues assessed biomarker measurements in the blood that showed evidence that the drug was removing cholesterol from the brain.

In the study of people with early ADPKD and healthy kidneys, researchers also tested if decreasing blood pressure below usual targets would slow progression of ADPKD and preserve kidney function.

Alzheimer's disease is the most common dementia type, with no treatment to slow down the progression of the disease currently available.

I read with interest the report that taking very high doses of vitamin C slows the progression of leukaemia in...

«If we can identify infants with NPC early, we could direct these children to clinical trials, potentially beginning treatment before they have begun to show symptoms of neurological damage, hopefully slowing disease progression and improving quality of life.»

As for therapeutics, Xavier, who is also the Kurt Isselbacher Chair in Medicine at Harvard Medical School and Co-Director of the Center for Microbiome Informatics and Therapeutics at MIT, says that knowing which species are absent and which are flourishing in the gastrointestinal tract of children with T1D may help make it possible to slow progression of the disease after onset by revealing ways to manipulate the microbiome and, in turn, microbiome - induced immunoregulation.

«As a community, we can all take pride in these improvements while continuing to learn as much as we can to slow down the progression of this disease and improve the quality of life for all those living with it.»

Treatment with miglustat, an inhibitor of lipid synthesis that is approved outside the U.S. for treatment of NPC, has shown evidence of slowing disease progression.

In the Ugandan cohort, higher T - cell activation and IL - 6 were associated with faster disease progression, whereas IFABP levels, indicative of enterocyte turnover, was elevated in slow progressors compared to fast progressors.

They found that early phenformin treatment causes increased survival and slower tumor progression in tumors lacking LKB1, but had no significant benefit for tumors with alterations in other lung cancer genes.

Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain, immune system, and blood vessels — with the ultimate goal of designing new therapies that slow, stop, or reverse the progression of a wide range of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a type of immune cell that acts as the brain's first line of defense — are activated when fibrinogen enters the brain or spinal cord.

Early Intervention with an Estrogen Receptor β - Selective Phytoestrogenic Formulation Prolongs Survival, Improves Spatial Recognition Memory, and Slows Progression of Amyloid Pathology in a Female Mouse Model of Alzheimer's Disease.

The drugs help slow the progression of the disease, and can help relieve symptoms such as pain, nausea, and bloating associated with the cancer.

Behaviorally, the mice with 110 CAG repeats showed a sharp decline in both rotarod and open field performance from around 4 weeks of age whereas the 240 CAG repeat mice displayed a 2 - 3 week delay in the onset of behavioral decline with a much slower progression of decline in both tasks as compared to 110 CAG repeat counterparts.

Thus, J147 is an exciting, new compound with strong potential to be an AD therapeutic by slowing disease progression through neuroprotection as well as providing rapid cognition benefits by reversing cognition deficits following short - term treatment.

But the next big trial is likely to focus on people with relatively early HD symptoms, so that it has the best chance of showing slowed progression.

CHDI is a private, not - for - profit research organization, working with an international network of scientists to discover drugs that slow the progression or delay the onset of HD.

Nature Medicine Study Describes a Novel Senolytic Molecule that Slows the Progression of Osteoarthritis April 24, 2017 SAN FRANCISCO, April 24, 2017 / PRNewswire / — UNITY Biotechnology, Inc. announced today the publication of new research in the journal Nature Medicine demonstrating that the selective elimination of senescent cells with a drug may delay, prevent, or even reverse the progression of osteoartProgression of Osteoarthritis April 24, 2017 SAN FRANCISCO, April 24, 2017 / PRNewswire / — UNITY Biotechnology, Inc. announced today the publication of new research in the journal Nature Medicine demonstrating that the selective elimination of senescent cells with a drug may delay, prevent, or even reverse the progression of osteoartprogression of osteoarthritis (OA)

The findings demonstrate similarities in progressive muscle weakness and a decline in motor coordination in both models of motor neuron disease with a later onset and slower progression noted with PFN1 animals.

Emphasising their desire to move the drug forward, in a separate announcement made directly to the HD community, Ionis said «Upon study completion, the next step for this program will be to conduct a study to investigate if decreasing mutant huntingtin protein with IONIS - HTTRx can slow the progression of this terrible disease.»

Other endpoints may focus on different things, such as depression in a drug designed to help with mood symptoms, or overall functioning in a drug aimed at slowing progression.

And in animal studies using mice with HD, research has shown that «environmental enrichment» - giving the mice more stimulating surroundings - delays the onset and slows the progression of the disease.

Studies suggest that the earlier a person with Alzheimer's disease is treated with anti-dementia medications, the more likely the medication will be effective in slowing the progression of the disease.

Next Page: Marijuana doesn't slow down RA [pagebreak] On the other hand, while marijuana may help with pain symptoms, it does nothing for the disease progression or organ damage, Dr. Mbakwe says.

For patients with inflammatory bowel disease, medications — including steroids, immunosuppressants or anti-inflammatory drugs — are used to slow the progression of disease.

Fish intake, particularly as part of a healthy diet, such as the Mediterranean diet, has been linked with decreased Alzheimer's disease or slower disease progression, Kroger said.

In the study, the participants with preexisting white matter lesions who followed a program of upper and lower body weight training twice a week over the course of one year had a significantly slower progression of the white matter lesions.