«These are clinically significant findings, with this magnitude of blood pressure reduction being comparable to that expected with the addition of an anti-hypertensive medication and larger than effects usually seen
with sodium restriction in people without CKD,» said McMahon.
Not exact matches
Sodium restriction was associated
with a significantly higher risk of death or heart failure hospitalization (42.3 percent versus 26.2 percent, hazard ratio 1.85).15
Joy Dubost, a dietitian
with the Academy of Nutrition and Dietetics, says that although the Paleo diet can help followers control their intake of sugar,
sodium and processed foods, its
restrictions on healthy foods like brown rice can leave you without an adequate intake of the B vitamins, magnesium, phosphorus, vitamin D and calcium.
These amounts are also referring to healthy adults, and not necessarily someone who has a disease or condition which requires them to follow specific dietary
restriction, such as those
with chronic kidney disease who may need to limit their protein intake or someone
with high blood pressure who it is recommended limit their
sodium intake to 1,500 mg per day.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together
with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated
sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric
restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain,
with the significant exception of its use in the treatment of convulsion diseases.
In pets
with mild heart disease (those that are not showing any symptoms), only mild
sodium restriction is recommended.
No
sodium restriction is necessary in pets
with heart disease unless the condition has progressed to retention of fluid in the lungs (night cough) or in the abdomen (tummy).
Moderate
sodium restriction is important in dogs
with moderate heart disease, but severe heart disease requires very strict
restriction.
For cats
with congestive heart failure significant
sodium (salt)
restriction is recommended and
with refractory congestive heart failure may require extreme
sodium restriction to help maintain their comfort when symptoms can not be well - controlled
with medication.
This could be a problem in patients
with congestive heart failure or other patients who require
sodium restriction May stunt growth if used in young, growing animals May lower seizure threshold and alter mood and behavior At high doses, this medication can cause birth defects early in pregnancy, be irritating to the stomach or cause higher than normal blood sugar levels If your pet has received high doses, it should not be vaccinated without your veterinarian's advice as the vaccine may not work or it may actually give your pet the disease you are trying to prevent Less common side effects include weight gain, insomnia, panting, diarrhea, vomiting, elevated liver enzymes, pancreatitis and behavior changes Serious side effects are not expected
with routine use.
Robertson GL: Evaluation of the plasma vasopressin, plasma
sodium, and urine osmolality response to water
restriction in normal cats and a cats
with diabetes insipidus.