Sentences with phrase «with specific markers»
The scientists then stained the embryo with specific markers to identify cell populations.
https://www.the-scientist.com/ Not exact matches
For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.
The company wanted to use it as a diagnostic marker for disease: If synthetic versions of antibodies could be tagged with aequorin in the lab, then whenever they matched up with an antigen (or surface protein) of a specific pathogen in blood or tissue, the sample would glow.
Abiraterone's ability to lower levels of prostate - specific antigen, a surrogate marker for prostate cancer, was slightly greater for patients in the low - dose with food group when measured at 12 weeks.
«One can imagine that a SLIM - based tissue imager will scan biopsies in a clinic and, paired with software that is intelligent enough to look for these specific markers, will provide the pathologist with valuable new information.
The researchers showed that the latest approach to epidemiology worked to track both HIV infections and levels of prostate - specific antigen, a molecular marker associated with prostate cancer.
A chromosome - specific BAC library was used to assemble 82 % of the chromosome into 1036 contigs that were anchored with 1443 molecular markers, providing a major resource for genetic and genomic studies.
All had been treated previously with at least one type of androgen deprivation therapy and had rising levels of prostate specific antigen (PSA), a blood marker for prostate cancer, and radiographic evidence their cancers were becoming resistant.
The tumour has completely disappeared in the two patients after three to four treatments and can no longer be detected neither by PET / CT imaging nor by the tumour marker PSA (Prostate - specific antigen), whose blood level is often elevated in men with prostate cancer.
Molecular markers — pieces of DNA that «mark» a specific gene — allow researchers to comb the genetic blueprint of a plant, match the sequence with a certain trait using computer programs, and develop seeds.
The polarity marker determines the polarity site, and with membrane vesicle transport toward it, site - specific growth (polarity growth) is achieved.
The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.
The team selected cells with cardiac - specific markers from cultures of HES cells.
Professor David Wraith, who led the research, said: «Insight into the molecular basis of antigen - specific immunotherapy opens up exciting new opportunities to enhance the selectivity of the approach while providing valuable markers with which to measure effective treatment.
Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.
With SABT2 as a marker, the researchers show BMP signaling is required for development of tissues specific to the posterior gut region of frogs and mice where the colon develops.
Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.
The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease
Thus, as the inflammatory cascade progresses from nonatrophic gastritis through the atrophic gastritis — intestinal metaplasia — neoplastic spectrum, it was found that these 5 specific markers were statistically significant in predicting precancerous lesions in comparison to traditional risk factors (receiver operating characteristic, 0.803 vs 0.580).70 As discussed previously, intestinal - type gastric cancer is more strongly associated with the atrophic gastritis and intestinal metaplasia cascade, thus explaining the closer correlation with intestinal - type gastric cancer and the serologic biopsy than diffuse - type gastric cancer.
Control and gesicle - treated hiPS cells were assessed for AcGFP1 expression (green), labeled with an antibody specific to pluripotency marker Oct ‑ 4, visualized with a fluorescent - labeled secondary antibody (red), and nuclear - labeled with DAPI (blue).
To determine pluripotency and AcGFP1 knockout efficiency in gesicle - treated cells, cells were labeled with a fluorescently labeled antibody specific to the pluripotency marker SSEA - 4.
In addition, the presenter will provide guidance on experimental design for multiplexed antibody panels combining phenotypic markers with phospho - specific intracellular targets, and discuss the use of fix and perm kits.
«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.
Gender - specific alterations in fibrin structure function in type 2 diabetes: associations with cardiometabolic and vascular markers
To characterize activation of immune cells, measurement of intracellular signaling using phospho - specific antibodies combined with immune phenotyping using surface markers is ideal.
Cells were stained with antibodies specific for human cell surface markers: CD326 / ESA - FITC, CD24 - PE, and CD44 - PE - Cy7 (BD Pharmingen, San Jose, CA, USA).
By using immunoprecipitation and mass spectrometry, we identified autoantibodies anti-Adenylate kinase 5 (AK5 - Abs) as specific marker in 10 patients with LE.
By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].
Researchers use these receptors — or markers — to identify and isolate adult stem cells by «tagging» the chemical messages that bind to those specific receptors on the stem cell with fluorescent molecules.
(A) Retinal section obtained from a P150 eye immunostained with human - specific nuclear marker.
During sabbatical in the laboratory of Chris Tyler - Smith (Wellcome Trust Sanger Center), I genotyped the Y chromosome of HapMap samples with 16 short tandem repeat (STR) markers as well as lineage specific markers to determine whether the Y chromosome genetic information in this sample was consonant with the purported ancestry of the subjects.
These cells often have virus - specific T cell receptors, as well as other surface markers that distinguish them from their youthful counterparts, and they are thought to play a major role in the decline of the immune system with age.
An inherent problem with this approach is that the presence of specific cell surface markers does not directly reflect the transcriptional state of a cell.
As seen in cells dissected from colonies, significant numbers of cells coexpressed lineage specific markers along with pluripotency genes.
The antibodies listed above in the immunocytochemistry section were also used on eye sections together with a cocktail of antibodies generated against human - specific markers (HSM) to identify human cells (the Oka blood group antigen, mouse TRA -1-85, 1 ∶ 10 (a kind gift from Peter Andrews, University of Sheffield, Sheffield, UK) together with mouse human nuclear antigen, 1 ∶ 1000, Millipore).
Studies utilising autosomal, Y chromosomal and mitochondrial DNA markers in selected Pakistani populations revealed a mixture of Western Eurasian -, South - and East Asian - specific lineages, some of which were unequivocally associated with past migrations.
Known and novel independent prognostic markers were identified in our cohort of proteasome inhibitor and IMiD - treated patients with long follow - up, including events with context - specific prognostic value, such as deletions of the PRDM1 gene.
A specific genetic marker has been shown to be associated with increased BMI and waistline.
Moderate - to - high IgG reactivity to specific dietary antigens in the absence of a complement marker * may be associated with high titers of IgG4 and a variable risk for systemic food intolerance.
«Given the high content of certain specific polyphenols in the juice blend, the increased antioxidant protection [in the body] after consumption of the juice blend, and the anti-inflammatory capacity in vitro, further research is warranted to evaluate whether juice blend consumption may provide reversal of risk markers in subjects with conditions such as arthritis, obesity, chronic viral diseases, cardiovascular disease and compromised cognitive function, as well as other conditions associated with chronic inflammation,» wrote lead author Gitte Jensen from Holger NIS Inc., a contract research laboratory.
Apparently I have VERY SPECIFIC memories attached to those stamp markers, because I got this flashback to one summer when we were having our kitchen redone and my cousin and I went buck nutty with those things.
For those with specific needs with regards to age, religion, or with alternative dating lifestyles, I'd probably recommend a more niche dating site instead, or at least one that allows you to choose these markers with a definitive Yes or No.
Unique equipment includes a NISMO body kit including a specific rear spoiler, plus Recaro sports seats, a black / red NISMO Alcantara / leather steering wheel with red - stitched centre marker, red start button and, for auto versions, red paddle shifters.
GMG modifications include: GMG WC Center Exhaust System with Dual 4» Tips ($ 2,600), BMC High Performance Air Filter ($ 209), GMG Porsche 991 GT3 / PMNA Carbon Fiber Dive Planes ($ 1,645), GMG LMS Gen 2 Harness / Roll Bar ($ 3,470), Schroth 6 Point Harnesses with Cam Locks & HANS for 991 GT3 Specific in Black ($ 1,703), Fire Extinguisher & Roll Bar Mount for Fire Extinguisher ($ 480.75), Sparco SPX Carbon Fiber Sport Seats ($ 6200), GMG 992 Seat Base ($ 1,715), GMG Seat Modification for Schroth Harness, GMG Street / Track Alignment & GMG Ride Height Adjustment ($ 700), Pirelli P Zerop Trofeo R Tires Front 245 / 25/20» Rear 305 / 30/20» ($ 2,890), GMG Front Tow Hook ($ 165), Protective Wrap (Full Front End Wrap, Front Bumpers, Front Fenders, Hood & Mirros, Complete Rear Bumper Wrap, Exterior A-Pillars ($ 2,995), Tinted Windows Xpel FX35 % Medium Window Tint, Upgraded Sound System ($ 2,352.76), Porsche European LED Side Markers ($ 225) and New Factory Porsche TPMS Sensors ($ 463.79).
Genetic studies have linked multiple forms of cancer with specific breeds and more will likely be discovered as genetic markers are identified.
In much the same way that clicker training uses to train the dog that the clicker is always followed with a reward, compulsion based training uses a specific verbal marker that is always followed by an aversive action (leash pop, e-collar correction, etc.).
You're able to adjust on the fly, but I found the volume slider to not be very precise, as I wished it was a dial setting with more «markers» for specific volume levels since it either sounded too low or loud without much room in between to find that perfect setting.
Beasley's work often incorporates clothing or other items of personal significance, drawing on associations with a specific person or general markers of identity and memory.
In creating the marker as a lightweight, movable, and contingent form, Durham presents a «center» that transcends the conventional boundaries of a specific location, similar to the «I» in Walt Whitman's «Song of Myself»: «I pass death with the dying, and birth with the new - washed babe... and am not contained between my hat and boots.»
Imaging studies using these composite measures of SES have found significant correlations between composite scores and regions in the medial temporal lobe and frontal lobe (Raizada et al., 2008; Jednoróg et al., 2012), but without knowing associations to specific SES markers, it is difficult to compare these studies with other structural imaging studies.