Sentences with phrase «with specific phenotypes»

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

Not exact matches

Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma.»

Alternatively, a breeder could, using individuals of differing phenotypes, create a new breed with specific characteristics.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

Those data were then combined with information about functional changes in cell behavior to develop a nanomechanical profile, or phenotype, for specific cellular states.

In compound heterozygous mice, both homozygous lethal Xpd † XPCS and Xpd † XP alleles were able to alleviate XpdTTD - specific cutaneous and anaemic features and can thus be defined as dominant over the XpdTTD allele with respect to these phenotypes.

Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from Adominant arecessive to Arecessive adominant with respect to different phenotypes in a time - dependent and tissue - specific manner (see below and Table 2).

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus Erythematosis by utilizing deCODE's expertise in gene discovery.

To analyse the extent of DNA damage response (DDR) in resistant phenotype, we treated spheroidal clonospheres with specific concentrations of Bleomycin.

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

Interaction of human mesenchymal stem cells with cells involved in alloantigen - specific immune response favors the differentiation of CD4 + T - cell subsets expressing a regulatory / suppressive phenotype.

These analyses demonstrated very unique and specific features of the susceptible versus control mice, which include a hypoactive and anxious phenotype with reduced mobility, rearing, digging and sniffing as well as increased freezing and exploratory stretching behavior.

To characterize activation of immune cells, measurement of intracellular signaling using phospho - specific antibodies combined with immune phenotyping using surface markers is ideal.

The successful candidate will leverage the extensive mouse - specific resources of The Jackson Laboratory in combination with classic mouse genetics, current ocular phenotyping and molecular biological techniques, and advanced technologies, such as CRISPR and single - cell RNA - Seq, to address his or her scientific questions.

Establish collaborative «networks» with specialist phenotyping consortia or laboratories, providing standardized secondary phenotyping that enriches the primary dataset, and end - user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research.

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus...

A thorough longitudinal analysis of the CMV - specific T cells in nonagenarians showed a stable pattern with respect to frequency, phenotype, and clonal composition.

Topics of interest include gene - environment interactions, genetic associations with asthma - associated phenotypes such as allergies and lung function, and the role of tissue - specific gene expression.

Three females with the c. 329 G > A p.Arg110Gln variant, present with a phenotype of mild ID, specific facial features, scoliosis and craniosynostosis, as reported previously in a single patient.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Focussed on our chosen disease area, Type 2 Diabetes Mellitus (T2D, previously referred to as non-insulin dependent diabetes or adult - onset diabetes), a common chronic disease, Phenomap provides an interface that allows users unfamiliar with mouse models to filter and display mouse phenotyping information according to their specific research interests.

Some specific phenotypes for cycling women and / or menopausal women that - that will help with even some of those symptoms of the receptor site level, depending if we have a cycling or a menopausal issue.

The EBV measures the potential of an animal to pass a specific trait to its offspring and is calculated using the animal's phenotype (where available) and those of relatives, in conjunction with pedigree relationships.

The widely used strategy of allele association investigates correlations of gene variants with phenotypes, i.e., it probes if individuals with a trait of interest carry a specific gene variant more frequently than individuals in a control group (case - control studies).