Sentences with phrase «with subsequent developments»

However, it has failed to keep pace with subsequent developments in company law and accountability requirements given the size and numbers of Indigenous corporations today.

While condemning anti-Semitism, the draft contained sharp criticisms of Jews and Judaism that are, at least in tone, inconsistent with subsequent developments in Catholic teaching.

Infection with Epstein - Barr virus (EBV), the cause of infectious mononucleosis, has been associated with subsequent development of systemic lupus erythematosus and other chronic autoimmune illnesses, but the mechanisms behind this association have been unclear.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

While cognitive tests have a slightly closer correlation with job success, personality tests are useful both as a basis for interview questions and for subsequent development.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

Focusing exclusively on high - potential products that align with health system priorities and patient needs, EXCITE's pre-market approach identifies opportunities for improvement while products are still in development, resulting in better technologies for patients and lower system costs, while also streamlining the subsequent adoption process.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The subsequent centuries have witnessed endless conflict over the Christian cultus, but one element in the long development of Biblical experience and thought concerning fellowship with God has remained as the common and unifying gain of all — «Thou, when thou prayest, enter into thine inner chamber, and having shut thy door, pray to thy Father who is in secret.»

I will, however, take two essays I published in the 1970s (both included in Beyond Belief) as intellectual benchmarks with respect to which I will measure changes, developments and continuities in the subsequent years.

My concern at this juncture is with the biblical witness itself, as crucial springboard for — and basis for judgment of — subsequent developments in the church's theologizing.

Consider a partial list of developments since just World War II: a broad national decline in denominational loyalty, changes in ethnic identity as hyphenated Americans enter the third and subsequent generations after immigration, the great explosion in the number of competing secular colleges and universities, the professionalization of academic disciplines with concomitant professional formation of faculty members during graduate education, the dramatic rise in the percentage of the population who seek higher education, the sharp trend toward seeing education largely in vocational and economic terms, the rise in government regulation and financing, the great increase in the complexity and cost of higher education, the development of a more litigious society, the legal end of in loco parentis, an exponential and accelerating growth in human knowledge, and so on.

McGrath is aware of the risk of slipping into Deism - with a creator sitting back and detachedly watching his creation unfurl - hence, his emphasis on the importance of a Trinitarian approach, in which God not only intervenes in the subsequent development of His Creation, but in which the whole Christian economy of salvation is worked out.

The generic character of John XXIII's original intentions for the Council, of course, was essentially responsible for much of the subsequent struggle between the Council Fathers and the Roman curia, the latter being accustomed to dealing with «live issues» rather than with general goals of development.

And the story of subsequent Jewish political development is to be traced, not primarily in the hierarchy of restored Palestinian Judaism and the arrogance of the House of Hasmon, but in the popular assembly with its ruling elders which continued, with local adaptations and variations, it is true, but in essential uniformity, right through the long centuries of the dispersion and into our own times.

If Isaiah's Messianism has an eschatological flavor, that is, if it anticipates a growing concern in subsequent centuries with the «last things,» we may remark that this is, for Isaiah, the goal of history; that Isaiah may indeed be the father of Jewish and Christian eschatology; but that for Isaiah it is a «natural» and consistent development of a very real covenant history.

This, however, does not affect the crucial fact, from which the subsequent development of Israel's religion proceeds, that the distinctive faith of the Hebrews began with the covenant between them and a deity new to their allegiance.

But this is a historical question; what is important in this context is the fact that the subsequent development of Greek, medieval and modern philosophy was largely dominated by the contrast between the timeless realm of Being and the temporal realm of change; in this sense, it was a continuation of the dialogue between Parmenides and Heraclitus, with Parmenides having an upper hand.

In 2007, researchers published the first randomized, controlled study of the effect of being raised in an orphanage; that study, and subsequent research on the same sample of Romanian orphans, found that compared with babies placed with a foster family, those who were sent to institutions had lower IQs, slower physical growth, problems with human attachment and differences in functioning in brain areas related to emotional development.

First, fathers» interactive play during toddlerhood has been longitudinally associated with attachment security in later childhood and adolescence.17 Second, fathers» speech and language interactions with infants have been positively associated with language development, and paternal depression has been shown to adversely impact this process.18, — , 20 Third, discipline practices, such as corporal punishment, have been longitudinally associated with increased child aggressive behavior.21 In addition, paternal depressive symptoms have been longitudinally associated with harsh paternal discipline practices in older children and subsequent child and adolescent maladjustment.11 Finally, as an indicator of fathers» interactions with pediatric providers, we also examined the proportion of depressed fathers that reported talking with their children's doctor within the previous year.

Some studies do link the use of marijuana with premature birth, lower birth weight and even compromised neurological development which has subsequent behavior issues in the children.

In a related study published recently in the journal Child Abuse and Neglect, Valentino found that maltreating parents, many of whom had experienced childhood trauma, could successfully be taught to use more elaborative and emotion - rich reminiscing with their preschool - aged children, which has been linked to a children's subsequent cognitive abilities in a number of areas including memory, language and literacy development.

The author discusses the production of Salk vaccine at Cutter Laboratories, the tragic effects of the inadvertent injection of 200,000 people with live virulent polio virus, the subsequent legal proceedings, and the shadow those have cast on the development of new vaccines.

As reported by Theodore Kotchen et al. and Howard Dickler et al. in The Journal of the American Medical Association in 2004 and 2007, respectively, about 40 % of M.D.s with K08 (mentored clinical scientist development) awards do not even apply for a subsequent first independent (R01) grant.

Moreover, achieving normal glucose levels — even briefly during the trials — was associated with a substantial reduction in subsequent development of type 2 diabetes.

Our experience with mp3 and the subsequent technologies served as a good measure for those developments,» says Max Neuendorf, group manager of the IIS Audio and Speech Coding team.

The nerve cells of the central nervous system (CNS), which is composed of the spinal cord, the brain, and the retina, must be supplied with sufficient oxygen and nutrients through the blood vessel system during development and their subsequent function.

Head circumference, in turn, has been associated with subsequent cognitive development.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Foto: Mikael Wallerstedt A team of Swedish scientists have used national registries encompassing more than one million Swedish children to study the association between early life contact with dogs and subsequent development of asthma.

The objectives to achieve within the 4 years of the NAREB project are: 1 / to select antibacterial molecules and design nanocarriers with strong antibacterial activity, 2 / to test in vitro and in vivo the best therapeutic combinations including innovative genomic and bioimaging approaches, 3 / to assess safety, regulatory and production (GLP / GMP) aspects for the most promising nanoformulations, and 4 / to establishing the Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations.

In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development.

Over the last year, I've experienced three consecutive miscarriages, each subsequent one with slightly more embryonic / fetal development.

despite the seismic changes in critical fashion during the past half century, auteurism — at its most basic, the idea that there is an author to a film — has been central to the historical development of both popular film and serious film criticism and theory... aspects of auteurism have overlapped with virtually every subsequent critical theory and paradigm.

In our study, teachers had no prior experience using a project - based approach, and we had limited time to devote to professional development (about three hours initially, with brief videos introducing subsequent units and an average of 11 visits from coaches), so it was important for the unit and session plans to provide considerable support through explicitness and detail.

In my view, this is an important difference between the two sectors, since strong and cohesive professional - development sessions with subsequent mentoring and assessment is one of the most promising methods for heightening school effectiveness.

The risk assessment feeds in at the evaluate risk stage, with the development and implementation of a security strategy feeding into the subsequent two steps.

The Alabama Best Practices Center (ABPC) ~ a professional development arm of A + Education Partnership ~ was created because its leaders believed there was great potential in forming substantial partnerships with educators at all levels in public education to help inform policy - making on the state level and address disconnects between the intent of policy and subsequent implementation.

Dear Prof Masters, There is one main mitigating factor against the capacity of the school systems in Australia to address, with flexibility, the slower start and subsequent development of some children because of inherent learning disabilities, socio - economic factors or any of the myriad factors that affect child development.

Through subject - specific professional development and subsequent use of interactive lessons, the teachers felt confident in their ability to use, but not create with, the IWB in mathematics.

Since the 2008 Melbourne Declaration on Educational Goals for Young Australians and its subsequent reforms, public and private school teachers have been required to engage with the Australian Professional Standards for Teachers and the Australian Professional Standard for Principals, two documents that articulate a continuum of teacher development from graduate to principal.

Readium.js and the core JavaScript modules Readium.js shares with Readium SDK were developed subsequent to the initial development of Readium Chrome Extension, which is not (as of September 2013) «synched up» with the new more modular architecture for these components.

However, going from past developments, my money is on Amazon, not only to do well with the Fire but to improve it and give the iPad a run for its money in subsequent generations.

Sure, sounds good... feel free to move any posts subsequent to your above post (including this reply), if you wish, to a new thread with any development (s).

Vaccination of pet and research dogs with polyvalent vaccines containing rabies virus or rabies vaccine alone was recently shown to induce production of antithyroglobulin autoantibodies, a provocative and important finding with implications for the subsequent development of hypothyroidism (Scott - Moncrieff et al, 2002).

The controversy surrounding Team Bondi's treatment of their staff and subsequent liquidation can't have helped, but in a chat with IGN, Rockstar Jeronimo Barrera, VP of Product Development, revealed the delay boiled down to the studio wanting to finish all the console DLC first before beginning work on the PC port, which they didn't want to rush.

«And that's because our developers, starting with Mr. Miyamoto and going through the entire EAD development organisation, they understand the power of our franchises, and they understand that the only reason these franchises have the power that they do is that they have to make sure that each subsequent edition is unique, different and offers something new.

With all the big news regarding Amazon going live with its Appstore, and Apple's subsequent suing of Amazon for using said name, you may have missed the really exciting development - Angry Birds Rio has finally landed.As well as being a free offering... Read With all the big news regarding Amazon going live with its Appstore, and Apple's subsequent suing of Amazon for using said name, you may have missed the really exciting development - Angry Birds Rio has finally landed.As well as being a free offering... Read with its Appstore, and Apple's subsequent suing of Amazon for using said name, you may have missed the really exciting development - Angry Birds Rio has finally landed.As well as being a free offering... Read more

Fortunately, the developer was able to strike a deal with new publisher Paradox Interactive to continue development, but not before it had decided that subsequent episodes (Episode 2 and 3) would be merged together as a single release, thereby concluding the story that was in Penumbra: Black Plague.