Sentences with phrase «with substantial decreases»

The flourishing of human life and cultures is compatible with a substantial decrease of the human population.

Transient transfection of ALCL cells with specific mTOR siRNA (20 μg) resulted in almost complete inhibition of mTOR protein expression at 48 hours (B) associated with a substantial decrease of p - p70S6K and p - rpS6 (not shown).

Our quantitative assessment of doublecortin (DCX) immunoreactivity in the dentate gyrus showed a loss of DCX in aged animals (Supplemental Figure 1), consistent with a substantial decrease in the neurogenic capacity of the aged hippocampus.

There was also a clear impact on their classroom behaviour with a substantial decrease in off - task activity.

Not exact matches

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

All these changes have been substantial, with increases or decreases of more than fifty percent.

Reports remain unchanged out of Argentina and Chile, with both countries reporting substantial decreases in output from the previous year.

Even with small reformulations — to decrease levels of salt in certain products, for instance — the impact on population health can be substantial.

«We saw substantial decreases at 2.5 percent of BA and nearly complete protection at the 10 percent concentration, strongly indicating that insect repellents with good safety profiles can be useful to reduce fruit damage during ripening.»

By examining the brains of these mice, the researchers observed a substantial decrease in inhibitory CA2 neurons, as compared to a control group of normal, healthy mice — a change remarkably similar to that previously observed in postmortem examinations of people with schizophrenia.

And only five countries — Armenia, China, Croatia, Ukraine, and Uruguay — showed a substantial decrease in individualistic values over time, with 39 out of 53 countries showing a substantial increase.

However, the large - scale nature of heat content variability, the similarity of the Levitus et al. (2005a) and the Ishii et al. (2006) analyses and new results showing a decrease in the global heat content in a period with much better data coverage (Lyman et al., 2006), gives confidence that there is substantial inter-decadal variability in global ocean heat content.

«There's a really substantial amount of research that correlates more plant - based diets with decreased risk of chronic diseases [such as] heart disease, cancer and diabetes.»

A 1996 survey of research studies found substantial evidence that less sleep is associated with a decrease in cognitive performance, both in laboratory settings and through self - reported sleep habits.

These include: 1) a substantial decrease in student enrollment; 2) the curtailment or alteration of an educational program as a result of substantial decline in enrollment or to conform with standards of organization and education as required by law or recommended by the state Department of Education; 3) consolidation of schools or districts, or 4) the reorganization of a school district.

Honda's dedicated hybrid, the Insight, saw a substantial decrease in sales compared to September 2010, with just 512 units sold compared to 1679 last year, a loss of 69.5 percent.

«Research has shown huge decreases in fees, especially late fees and over-balance fees, with no substantial increase in interest charges (or perhaps decreases).»

Well, as a general rule, the feeding frequency for dogs mostly depends on their age and should be progressively decreased from birth to adulthood, with the relevant exception of bitches in the latter stages of gestation and throughout the lactation period, which require a substantial change in the amount and frequency of food fed.

However, in dogs with substantial nonthyroidal illness, the free T4 is likely to be decreased.

«One of the shelter operations we have worked with found that they had a substantial decrease in respiratory - related feline issues and associated recovery costs when they stopped using the free clay litter that they could get and began purchasing our paper litter.»

River flows have generally increased in winter and decreased in summer, but with substantial regional and seasonal variation.

If the optical thickness and temperature distributions are such that the dominant spatial tendency in temperature is to either increase or decrease (as opposed to fluctuate) from a location out to a substantial optical thickness away, then farther increases in optical thickness will bring the flux and intensities coming from that direction toward the values they would have for a blackbody with a temperature equal to the temperature at that location.

«This reconstructed SIE shows a substantial decrease in the 1930 — 1940s with a minimum occurring in 1936, which, however, is only a * half of the decline in 2012 *.

Audubon's climate model shows only a modest overall decrease in winter in areas with suitable climate space; however, the model also shows a substantial shifting of that habitat northward and, more intriguingly, inland.

For many applications, solar water heaters, solar photovoltaic systems, small hydro and various energy efficiency options are mature, cost - effective technologies with decreasing costs and substantial environmental and economic benefits.

In previous millennia, while there is substantial concurrence, the agreement decreases with increasing antiquity.

The model also supports the notion of a substantial decrease (~ 25 %) in the overall number of Atlantic hurricanes and tropical storms with projected 21st century climate warming.

had the judge taken into account the husband's decreased income, together with his needs and debts, she would have ordered a substantial reduction in the maintenance and / or the imposition of a shorter term; and

Second, did FindLaw know that their conduct could be penalized by Google, with the penalty being a substantial decrease in the value of the PageRank being passed to the law firm websites Find Law was selling to?

However, the attorney fees associated with taking a case to jury can be substantial and may decrease your settlement significantly.

This, coupled with a substantial increase in equipment costs and a recent decrease in cryptocurrency prices, has created an environment where mining profits have been slashed to the bare minimums.

KEY ACHIEVEMENTS • Set up a system that worked on determining priorities and timetables, resulting in clear event program objectives • Simultaneously handled the details of two absolutely diverse events, both resulting in achieving their goals by a 100 % • Stayed within budget for 100 % of the assigned events, with 12 events being completed with substantial money left over • Incorporated the services of a new caterer, thereby decreasing catering costs by 50 %, while maintaining quality of food and beverages

Compared with other students, students with substantial hours of service learning, a lot of reflection, and a high degree of motivation attributed to service learning significantly increased their belief in the efficacy of their helping behaviors, maintained their pursuit of better grades and their perception that school provided personal development opportunities, and decreased less in their commitment to classwork.