Sentences with phrase «with substantial effects»

Just down the road from us is Didcot A power station, a large coal - burning plant with poor pollution control and therefore with substantial effects on local air quality, as well as more substantial emissions of radiation than from any UK nuclear power station and a Co2 output of about 8 million tonnes a year.

The results of the Tennessee program, in contrast, look very similar to Head Start, with substantial effects in the Head Start year but no longer - term effects.

Not exact matches

Thus, in contrast with what was originally found, GVT's data reveal a substantial, and statistically significant, hot hand effect.

Iger also reiterated comments he has made in the past to the effect that if ESPN wanted to, it could come up with its own over-the-top service similar to HBO Now, and that a substantial number of subscribers would likely pay for it.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Companies with much greater resources than Tribune and with a substantial head start are struggling in a rapidly changing environment to effect digital change that is profound enough and quick enough to overcome the outgoing tide of print revenues.

If there is a competitive drug market, with limited advantage offered by the new drug in terms of increased effectiveness or reduced side effects, the drug will probably not win substantial market share in its product category.

Due to the effects of market sentiment the gold price occasionally will diverge from its «true fundamentals» (as indicated by the GTFM) for up to a few months, but ALL substantial upward and downward trends in the gold price over the past 15 years have been consistent with the fundamental backdrop.

Jurisprudence in Australia has confirmed consistently the substantial lessening of competition test is concerned with the process of competition and not with the effect on individual competitors.

A business with a substantial degree of power in a market is not allowed to engage in conduct that has the purpose, effect or likely effect of substantially lessening competition in a market.

Preventing firms with a substantial degree of market power from engaging in conduct that has the purpose or effect of substantially lessening competition is now a central limb of Australia's competition laws.

It also requires that a corporation that already has a substantial share of a market must not directly or indirectly merge with or acquire assets which would have the effect or likely effect of lessening competition in a market.

As engaging with fathers around the births of their babies is the «golden opportunity moment» for intervention with them, this may have a substantial knock - on effect in terms of fathers» engagement with services — and in their children's lives.

Many of the epidural side effects mentioned below are not improved with low - dose or walking epidurals, because women using these techniques may still receive a substantial total dose of local anesthetic, especially when continuous infusions and / or patient - controlled boluses (single large doses) are used.34 The addition of opiate drugs in epidurals or CSEs can create further risks for the mother, such as pruritus (itching) and respiratory depression (see below).

«Acceptance of the KMC method is increasingly widespread and it is considered equivalent to conventional neonatal care for stable preterm infants and more parent and baby friendly... It is evident that KMC has a substantial mortality effect compared with conventional neonatal care, and it is also evident that this mortality benefit is possible even at large scale....

We judged all outcomes to be of moderate quality - stopping «any» breastfeeding at up to six months; «any» breastfeeding between four to six weeks; stopping exclusive breastfeeding at up to six months; or stopping exclusive breastfeeding between four to six weeks; all analyses had substantial heterogeneity even with a random - effects model.

However, the report qualified this by saying that «in terms of national resource use, the economic effects of a ban on hunting would be unlikely to be substantial», with the effects most likely to have dissipated within a decade, but that in the short term «the individual and local effects would be more serious».

The Disability Discrimination Act 1995 described a disabled person as someone with «a physical or mental impairment which has a substantial and long - term adverse effect on his ability to carry out normal day - to - day activities», which has or can be expected to last for more than 12 months.

Uber is going for the jugular in the escalating Big Apple cab wars — with a substantial drop in prices that was scheduled to go into effect this morning.

A drug with similar effects might generate substantial marketing... The very high heterogeneity... of effects among trials in the accompanying study highlights a research opportunity — to identify how to maximise the effect.»

The survey found that perpetration of domestic violence is associated with substantial negative effects on the productivity and safety of workers with close to half of respondents (46 %) reporting that violence issues negatively affected their job performance.

Because these exposures can contribute substantially to our cumulative ultraviolet exposures, the researchers contend, dietary factors with sun - protecting properties might have a substantial beneficial effect.

In the latter half of the decade, La Niña conditions persisted in the eastern and central tropical Pacific, keeping global surface temperatures about 0.1 degree C colder than average — a small effect compared with long - term global warming but a substantial one over a decade.

Writing in a linked Comment, Dr Shabbar Jaffar, Liverpool School of Tropical Medicine, UK, says: «The prevalence of diabetes in sub-Saharan Africa has increased rapidly in the past 10 years or so, affecting people in all sectors of society but, in particular, and disproportionally compared with high - income settings, affecting younger people, with substantial economic effects.

«The most exciting finding of our research was that not only did we see slower degeneration in the articular cartilage, we saw that the menisci degenerated a lot slower in overweight and obese individuals who lost more than 5 percent of their body weight, and that the effects were strongest in overweight individuals and in individuals with substantial weight loss,» Dr. Gersing said.

Ya'ara Leibovici - Weissman from Tel Aviv University said: «In treating cholera a quick and accurate diagnosis remains key, but it is clear from the results that antimicrobials result in substantial improvements in clinical and microbiological outcomes, with similar effects observed in severely and non-severely ill patients.

«The deterrent effect of delayed testing with newly devised analytical methods is substantial,» says the Consensus Statement, which suggests that in future it should be possible to detect the way in which doping can leave a «molecular signature» on individual cells.

The authors conclude that»... by 4400 years ago, early farmers had already had a substantial homogenizing effect on allelic diversity at three genes associated with maize morphology and biochemical properties of the corn cob.»

«These patients are too ill to receive any other treatment, but with stereotactic body radiotherapy we're able to deliver a safe and effective treatment in two weeks that can provide them with a substantial quality of life with minimal side effects.»

Alcohol and drug use disorders are believed to have substantial negative effects on outcomes in people with schizophrenia.

Amplification of existing health threats: The effects of extreme heat and heat waves, projected worsening air pollution and asthma, extreme rainfall and flooding, and displacement and injuries associated with extreme weather events, fueled by climate change, are already substantial public health issues.

Treatment with the vectors restored sperm production to substantial levels in all nine animals treated, without inducing any discernable side effects.

Freshwater flux has little effect on simulated Northern Hemisphere sea ice until the 7th decade of freshwater growth (Fig. 13d), but Southern Hemisphere sea ice is more sensitive, with substantial response in the 5th decade and large response in the 6th decade.

Despite 5 - year survival rates approaching 90 %, a substantial number of breast cancer patients relapse - and many more experience late treatment effects or are diagnosed with a second cancer.

However, this result is consistent with our previous studies in mice exposed to cigarette smoke plus bacteria, which demonstrate that cigarette smoke has substantial effects on bacterial clearance while having only minor effects on inflammatory cell number [20].

A recent review of NSAID use for dysmenorrhea (painful periods) concluded with a warning about the substantial risk of adverse effects including stomach bleeding, ulcers and upset stomach, high blood pressure, fluid retention and swelling, kidney problems, heart problems, and rashes.

These studies point to how supporting healthy cells with FWGE can have substantial effects on cancer cells.

Such alterations include avoiding processed foods rich in pro-inflammatory molecules, but also a focus on consuming substantial amounts of foods with documented anti-inflammatory effects, often raw and fresh green vegetables and tubers such as turmeric / curcumin.

From these studies, we know with confidence that long term ketosis may pose substantial risk for health complications due to the side effects experienced by the thousands of children who have followed ketogenic diets over the years as a means of suppressing seizures unresponsive to drugs and procedures.

Although these relatively small - scale intervention trials using viscous Functional Fibers have reported substantial cholesterol - lowering effects and therefore should be protective against CHD, no protective effect against CHD was seen in a large - scale clinical trial with individuals who had a previous myocardial infarction (Burr et al., 1989).

While Chu doesn't have any experience in the genre, the substantial budget helps him string together adequate set pieces with polished production values and passable visual effects.

Consistent with other research on school effects, we find that the school a student attends can explain a substantial share of the overall variation in test scores: that single factor explains 34 percent of the variation in math scores and 24 percent of the variation for reading.

Our findings are consistent with some research on the efficacy of Catholic schools, which finds substantial positive effects of attending a Catholic high school on educational attainment.

The results are consistent with other studies that show a substantial return (up to 50 percent of a standard deviation on standardized achievement tests) to achievement from observed classroom quality, with greater effects often accruing to children with higher levels of risk and disadvantage.

Although, as the authors note, «most non-urban students do reasonably well in any case,» the causal effect of a year of non-urban charter attendance is a substantial reduction in achievement in all levels and subjects, on the order of 0.16 standard deviations in middle school with almost a quarter of a standard deviation decline in high school math.

Among them are deleterious effects on children of unregulated and often substandard childcare; [9] lost productivity for employers due to parents missing work to handle gaps in childcare or to care for a sick child; [10] lost wages and reduced retirement benefits for parents who have to drop out of the labor market to provide at - home care for their young children; [11] a substantial downward pressure on the wages of childcare workers with effects on the quality and stability of the childcare workforce; [12] and lost opportunities for further education, [13] college savings, and other investments that working parents could make in themselves and their children but can not afford because they are spending most or all of their disposable income on childcare.

The proposed legislation, which hits the House floor this afternoon, would have two key effects: prohibit the possibility of engaging in a new, substantial mechanism to compare NC students» academic performance with that of students in other states; and authorize the creation of a review commission composed of parents, educators, and other stakeholders to review alternative standards and recommend them for adoption.

There are a lot of mistakes to make and underwater stoned to deal with, but still the most substantial difficulty one can face is disability to think up a cause and effect essay idea.

However, the election to file a joint return with a U.S. resident alien spouse has no effect upon the nonresident alien spouse's liability for social security and Medicare taxes if the nonresident alien spouse is an F - 1 student who is exempt from counting days of presence in the U.S. toward the substantial presence test in 2009.

A substantial list of Mass Effect 2 details were leaked on neoGAF this morning, most pertaining to story and lore with a few bits of gameplay information included in the long list as well.