The results of the study can be considered reassuring because «the use of medically indicated products does not appear to be associated
with substantial morbidity of sarcomas, and their propensity to cause tumors appears to be small.»
Hypertension is a major risk factor for cardiovascular disease and is associated
with substantial morbidity and mortality, estimated to account for 35 % of myocardial infarction and stroke, 49 % of heart failure, and 24 % of premature mortality (42).
Not exact matches
The extent of medicalisation in Spain is reflected in some of the highest caesarean section rates in Europe (26.4 % in Catalonia
with a 40 % increase over five years); obstetricians have been criticised for not allowing women to participate in decisions about their maternity care.11 Long term
morbidity after childbirth can be
substantial, 12 and this is particularly related to instrumental and caesarean delivery.
Sarcopenia, Greek for «poverty of flesh,» is a consistent manifestation of aging, associated
with frailty, metabolic disease, cardiovascular
morbidity and mortality, and
substantial health care costs [200, 201].
Hypochondriasis thus appears to be a disorder
with a
substantial burden of long - term
morbidity, functional impairment, and personal distress.
Marriage is the central relationship for the majority of adults, and
morbidity and mortality are reliably lower for married individuals than unmarried individuals across such diverse health threats as cancer, heart attacks, and surgery.1 - 4 Although loss of a spouse through death or divorce can provoke adverse mental and physical health changes,1,5 - 7 the simple presence of a spouse is not necessarily protective; a troubled marriage is itself a prime source of stress, while simultaneously limiting the partner's ability to seek support in other relationships.8 The impact of a turbulent marriage is
substantial; for example, epidemiological data demonstrated that unhappy marriages were a potent risk factor for major depressive disorder, associated
with a 25-fold increase relative to untroubled marriages.9 Similarly, other researchers found a 10-fold increase in risk for depressive symptoms associated
with marital discord.10