Sentences with phrase «with systemic administration»

In addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raised.

The Melanoma Intra-Tumoral CAVATAK and Ipilimumab (MITCI) study [26] of CVA21 in combination with systemic administration of ipilimumab in patients with unresectable melanoma is being conducted at three US sites.

Not exact matches

The administration's patent reform agenda «reflects recognition that there are systemic problems with the patent system,» Meurer says.

«The Administration has already begun the process to create the independent watchdog the Speaker is referring to by establishing a first - ever outside not - for - profit organization to monitor the system, advocate for the rights of people with special needs and disabilities and recommend future systemic reforms,» Introne said in the statement.

Corruption in Bulgaria remains systemic, present not only on the political stage but in the daily life of citizens who, when dealing with state administration, frequently have to resort to some form of bribery to receive needed services.

The beating death of a Brooklyn toddler was an «entirely predictable result» of systemic problems with how the Administration for Children's Services investigates child - abuse complaints on nights and weekends, the New York City Department of Investigation said.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

Last year the Food and Drug Administration approved Benlysta (belimumab), the first new treatment for systemic lupus erythematosus in more than 50 years, and Yervoy (ipilimumab), the first drug shown to prolong the lives of patients with melanoma.

Sequential Systemic Administrations of Combretastatin A4 Phosphate and Radioiodinated Hypericin Exert Synergistic Targeted Theranostic Effects with Prolonged Survival on SCID Mice Carrying Bifocal Tumor Xenografts Junjie Li, Marlein Miranda Cona, Feng Chen, Yuanbo Feng, Lin Zhou, Guozhi Zhang, Johan Nuyts, Peter de Witte, Jian Zhang, Jie Yu, Raymond Oyen, Alfons Verbruggen, Yicheng Ni Theranostics 2013; 3 (2): 127 - 137.

Long - term safety and efficacy following systemic administration of self - complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

Observations on the systemic administration of autologous lymphokine - activated killer cells and recombinant interleukin - 2 to patients with metastatic cancer.

The US Food and Drug Administration (FDA) recently approved the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib for the treatment of patients with relapsed or refractory marginal zone lymphoma who require systemic therapy and have had at least one prior anti-CD20 therapy.

Administration of this reagent into mice bearing human AL tumors or those with systemic AA deposits resulted in marked reduction in amyloid burden with no evidence of toxicity in the animals.

This protocol is a dose escalation study of Ad - hCMV - TK and Ad - hCMV - Flt3L infused at the time of surgical resection followed by systemic oral administration of valacyclovir in addition to current standard of care with temozolomide and radiotherapy.

FDA Approved Ibrutinib for Relapsed, Refractory Marginal Zone Lymphoma: Approval for the use of ibrutinib in patients with relapsed or refractory marginal zone lymphoma was granted by the US Food and Drug Administration for those patients who require systemic therapy who were treated with at least one anti-CD20 therapy.

As the Executive Director of High Schools for Edison Schools and the Chief Academic Officer for Great Schools Workshop in Sacramento, CA, Patrick worked with building and district administrations in nine states to implement systemic high school reform.

As Dropout Nation has documented over the past three years, the administration's No Child waiver gambit is already damaging systemic reform efforts on the ground; the administration's declaration last Saturday that there is supposedly too much testing, has also given ammunition to traditionalists and movement conservatives otherwise unconcerned with education policy.

But the fact that the Obama administration granted Virginia a waiver in the first place in spite of its record of obstinacy on systemic reform, along with the fact that many of the 32 other states granted waivers (along with the District of Columbia) have also set low expectations for districts and schools to improve the achievement of the poor and minority kids in their care, has put President Obama in the uncomfortable position of supporting the soft bigotry of low expectations for children — especially those who share his race and skin color.

By allowing states to ditch racial, ethnic, and economic subgroup categories and replace them with a super-subgroup subterfuge that commingles poor and minority students into one, the administration is making it difficult for families, especially black, Latino, and Asian families who are joining the middle class for the first time and moving into suburbia — to get the information they need to make smart decisions for their kids, and impede them from helping to advance systemic reform.

There's also the fact that dismay among progressive Democrats over the Obama Administration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syAdministration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syadministration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of systemic reform.

In concluding that the evidence in this case should be excluded due to the presence of racism, he cited the long - lasting systemic implications for the administration of justice if society did not see the justice system as acting fairly and in accordance with the equality guarantee in the Charter,