Sentences with phrase «with systemic therapy»

My experience in working with families, couples, and individuals joined with systemic therapy models offer a personalized treatment approach, utilizing your specific values, goals, and needs.»

In these patients, clinical results with systemic therapy have been less than optimal, and locoregional therapeutic options, such as limb perfusion and intralesional treatments, have thus been explored.

Patients often have available tissue blocks from nephrectomy specimens, but not from metastatic sites for analysis of biomarker expression, yet metastatic specimens are typically treated with systemic therapy, after nephrectomy.

Not exact matches

The study was a randomized phase II trial testing whether the addition of local treatment, in the form of consolidative radiation therapy, to the standard treatment of systemic therapy improved progression - free survival for patients with limited metastatic NSCLC.

«Even in the era of immunotherapy, there are not large numbers of metastatic NSCLC patients with durable responses to systemic therapy.

The therapy was found to have an acceptable safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR trials.

Radiotherapy to the chest wall and regional lymph nodes (under the arm, above the collar bone and under the breast bone), known as regional nodal irradiation, is used after mastectomy in women with node - positive breast cancer who are treated with adjuvant systemic therapy.

Previous history of myocardial infarction within 1 year prior to study entry, uncontrolled hypertension or uncontrolled arrhythmias • Pulmonary disease (e.g. COPD, asthma, etc) that is not controlled (moderate to severe symptoms) with current medication • Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy

The majority of these women will be cured with multimodality treatments including surgery, radiation therapy and systemic drug therapies.

[34] Despite high systemic RRs, many patients exhibit disease progression with CNS metastasis within 1 year of starting crizotinib therapy.

This is a highly heterogeneous disease with a higher risk of recurrence in the absence of systemic therapy.

The role of adjuvant systemic therapy in patients with mucosal melanoma following definitive therapy is not clear.

The US Food and Drug Administration (FDA) recently approved the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib for the treatment of patients with relapsed or refractory marginal zone lymphoma who require systemic therapy and have had at least one prior anti-CD20 therapy.

Intensive local therapy was followed by up to a year of less intense systemic treatment with cis - retinoic acid (a derivative of vitamin A) and interferon in an effort to control any microscopic tumors that had spread to distant sites from the initial cancer.

Systemic therapies are often given after surgery for those with a greater risk for cancer recurrence.

Patient 2 was diagnosed with widespread metastatic prostate cancer in 2013 and progressed on numerous systemic therapies, including leuprolide, bicalutamide, enzalutamide, abiraterone, and eventually docetaxel.

FDA Approved Ibrutinib for Relapsed, Refractory Marginal Zone Lymphoma: Approval for the use of ibrutinib in patients with relapsed or refractory marginal zone lymphoma was granted by the US Food and Drug Administration for those patients who require systemic therapy who were treated with at least one anti-CD20 therapy.

It has been generally surmised that intralesional therapies will be combined with the successful systemic immunotherapies — the checkpoint inhibitors or targeted therapies already approved or in development.

This would prevent the toxicity seen when patients are treated with systemic immune - boosting therapies and reduce the need for multiple rounds of T - cell treatment.

Phase 1b study of a novel immunotherapy combination therapy of intralesional Coxsackievirus A21 and systemic ipilimumab in patients with advanced melanoma.

Our ability to detect anti-HER2 antibody at the tumor site but not in the blood of NSC - treated mice suggests that this approach could have robust localized anti-tumor effect, while minimizing the systemic toxicity associated with traditional trastuzumab therapy.

Direct treatment of cutaneous melanoma lesions is on a separate track from that of systemic therapies, with its rapid advances.

Perhaps the greatest attraction and chief benefit of intratumoral therapies is their ability to synergize with systemic checkpoint therapies and accelerate the development of a lymphoid infiltrate and perhaps secondary lymphoid structures in vivo, which in turn can result in systemic mobilization of a T - cell response: the local injection — global effect model.

Preliminary analyses of the results of the first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as treatment for patients who can not tolerate systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.

Systemic AAV9 gene therapy improves the lifespan of mice with Niemann - Pick disease, type C1 Human Molecular Genetics, Oct. 26, 2016

As a doctor of physical therapy, gut health provides insight into why my patients (especially overweight or obese patients) develop osteoarthritis in non-weight-bearing joints like the wrist, by pointing to a problem with systemic inflammation.

Recognizing the increased need for antibiotic stewardship, the researchers consider HAAT to be a useful alternative to systemic antibiotic therapy that is effective and well tolerated among women with inflammatory acne.

Inflammatory breast cancer is generally treated first with systemic chemotherapy to help shrink the tumor, then with surgery to remove the tumor, followed by radiation therapy.

Therapy to abrogate the systemic infl ammatory response with antagonists of PAF (e.g lexipafant), IL - 1 and TNF - α holds promise for the future.

Patients with obvious abnormalities (B) suffering from systemic disorders with secondary diarrhea (B1a), such as hepatic failure, renal failure, hypoadrenocorticism, and EPI (B1b), should be identified before starting trial therapies.

These medicines are specifically produced for cardiac health or are administered in combination with other systemic therapies, in order to reduce symptoms and to enhance immunity and cardiac strength.

Clinical improvement of signs associated with systemic illness and pain is expected in the first week of antibiotic therapy.3 It is important that patients return for follow - up neurologic exams and radiography every 1 to 2 months to monitor for disease progression and to help direct therapy.

Clinical improvement of signs associated with systemic illness and pain is expected in the first week of antibiotic therapy.

While digital SCC is typically cured with surgery alone, digital melanomas are typically more aggressive requiring both surgery and systemic therapy to achieve long - term tumor control.

Inhalant steroid therapy allows direct application of steroid to airways with minimal systemic absorption.

Because of this, systemic chemotherapy is recommended as follow - up therapy for dogs with appendicular osteosarcoma.

EFT integrates the cutting edge science of adult attachment and bonding with a humanistic and systemic approach to therapy.

The therapists at Alpine Academy have a foundational stance of system theory while using a variety of approaches in their individual work with each student (i.e. cognitive - behavioral, systemic, experiential, dialectical behavior therapy, acceptance - commitment therapy, EMDR, etc.).

I have a systemic approach to therapy with an emphasis on cognitive / behavioral techniques.»

In this 1987 workshop Karl Tomm outlines a few basic assumptions and differences he and Michael White have with popular systemic family therapy models.

Drawing on my background in marriage and family therapy, I use systemic and narrative approaches to engage in collaborative work with clients.

Using a systemic approach to therapy, Deena enjoys collaborating with individuals, couples, and families to resolve problems and achieve personal and relational growth.

«I am Family Therapist trained in systemic, brief therapy models with experience in individual and family therapy, as well as play therapy, social skills groups and parent training.

With an advanced degree in family therapy, I work from a systemic perspective where we explore how individual family members are impacting each other and the family unit as a whole.

When working with couples and indivduals I encourage healing and recovery within an integrative style of systemic therapy.»

There are references to various systemic therapies, including in the Costing report: In the category of working with vulnerable and disadvantaged young people, there are references to family - based interventions and «intensive interventions (such as family therapy) for those who need it».

Methods: One hundred seven adolescent patients with DSM - III - R major depressive disorder (MDD) were randomly assigned to 1 of 3 treatments: individual cognitive behavior therapy, systemic behavior family therapy (SBFT), or individual nondirective supportive therapy (NST).

Systemic Family Therapy also facilitates the family's understanding of any local factors that may impact on their difficulties, for example, issues associated with areas of deprivation such as poverty and drugs.

Integrated Family Therapy invites caution when embarking on a therapeutic journey with a family: none of the most commonly occurring or most frequently cited issues in the systemic literature may turn out to be salient to that particular family during tTherapy invites caution when embarking on a therapeutic journey with a family: none of the most commonly occurring or most frequently cited issues in the systemic literature may turn out to be salient to that particular family during therapytherapy.

This research document was published in Family Process, December 2010 and entitled «The Efficacy of Systemic Therapy With Adult Patients: A Meta - Content Analysis of 38 Randomized Controlled Trials».