Sentences with phrase «with tacrolimus»
If the patient fails to respond in a positive or adequate manner following a treatment trial with CsA for 6 to 12 weeks, then initiating treatment with tacrolimus may be indicated.
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Wartman stabilized his GVHD with high doses of prednisone and the IL - 2 — dampening drug tacrolimus, but that wasn't enough suppression to resolve his symptoms.
«Tom persisted in using tacrolimus despite initial problems with toxicity that discouraged his peers, and he turned out to be correct,» describes Nicholas L. Tilney of Harvard Medical School, current president of the Transplantation Society and author of the 2003 book Transplant: From Myth to Reality (Yale University Press).
They found that a combination of two compounds - tacrolimus and sirolimus - allowed the cells to survive for up to 28 days in the mice with normal immune systems.
The kidney toxicity seen with cyclosporine and tacrolimus is particularly problematic in kidney transplant recipients and may negate a kidney transplant.
In addition, tacrolimus was also effective in some dogs in which treatment with CsA had failed.
All dogs previously diagnosed with KCS and controlled with topical CsA were successfully switched to tacrolimus therapy.
In addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raised.
In addition, combining tacrolimus with CsA in cases refractory to each administered alone may help improve overall response as tacrolimus has been shown to act synergistically with CsA in suppressing the proliferation of T cells in vitro.