A recent study of women whose cancer was treated
with tamoxifen therapy and who were also taking the antidepressant paroxetine demonstrates the potential problems of using these drugs: the patients increased their risk of death by 91 %.
Not exact matches
However, along
with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated
with anti-estrogen drugs like
tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these
therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.
There are also preventive
therapies — such as
tamoxifen or the trial drug anastrazole — that interfere
with the production of the hormone oestrogen, implicated in many breast cancers.
Letrozole is approved by the FDA for the adjuvant treatment of early - stage breast cancer in postmenopausal women who have already been treated
with 5 years of
tamoxifen therapy.
One study showed that when curcumin is used together
with tamoxifen in treating melanoma (the deadliest form of skin cancer), the combined
therapy selectively killed cancerous cells while preserving noncancerous cells.