Sentences with phrase «with telomerase»

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anaemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

Still, BioViva has pressed ahead with telomerase gene therapy, and factions within the research community are also aiming for the same outcome of human tests, though through more conventional channels.

Blocking the enzyme causes the cancerous cells to die, so the company is working with a telomerase inhibitor, imetelstat, that it hopes will kill tumor cells while leaving healthy ones unharmed.

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

Building on this «telomere hypothesis,» Geron's big idea was that tinkering with telomerase in cells could stave off their senescence — and prevent aging.

As in the former case, after being treated with telomerase gene therapy «the telomeres in the peripheral blood in these mice also lengthened and the number of blood cells increased considerably,» write the authors.

«That makes fooling with telomerase look like child's play.»

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

After a few weeks, they treat the animals with the telomerase gene therapy.

Not exact matches

Pioneers like Dr Dean Ornish and Dr Caldwell Esselstyn where among the first to show that if you combined a low fat, plant based diet, with walking and stress management, not only could you prevent and reverse heart disease (and many other chronic conditions), but you could also increase telomerase activity.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA.

She talks about her fascination with living things and the discovery of telomerase and telomeres.

The mutant unit bound with other building blocks of telomerase to create a dud enzyme that supplanted the native enzyme.

Mariela Jaskelioff and her colleagues at the Dana Farber Cancer Institute in Boston, Massachusetts, engineered mice with short telomeres and inactive telomerase to see what would happen when they turned the enzyme back on.

By reactivating telomerase activity in stem - cell derived tissue transplants, Geron could provide patients with a life - time warranty on their new parts.

With each division the telomere would shorten by a notch from whatever it had been when we took telomerase out.

Hockemeyer and his UC Berkeley colleagues, in collaboration with dermatopathologist Boris Bastian and his colleagues at UCSF, found that immortalization is a two - step process, driven initially by a mutation that turns telomerase on, but at a very low level.

The reason, he said, is that if a TERT promoter mutation arises to push a precancerous lesion — the mole or nevus — toward a melanoma, the chances are greater in someone with short telomeres that the cell will die before it up - regulates telomerase and immortalizes the cells.

As with all of our other genes, the DNA that encodes the telomerase enzyme is present in all of our cells — but because it's needed only after quite a few cell divisions have occurred, it's not needed in most cells for most or all of the time, so it's turned off.

The year 1993 was also about the same time that an enzyme close to the one she was working on, telomerase, was first associated with the development of cancer in humans.

In 2012, the CNIO Telomeres and Telomerase Group, headed by Maria A. Blasco, came up with a strategy to repair telomeres.

We're working with animal hosts where we put human cancers in and we try to attack the telomerase.

«This TFLY motif comprises a significant part of the binding pocket that enables the enzyme to grapple the RNA template and guide it to the active site of the enzyme for catalysis,» Skordalakes said, «but it also facilitates the stable association of the protein with its RNA component thus forming a fully functional telomerase enzyme.»

The second animal model attempts to reproduce hereditary aplastic anemia, which is produced by mutations associated with the telomeres and telomerase.

Stem cells, which have to divide regularly to regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.

«We provide proof - of - concept that the telomerase based treatment -LRB-...) has a therapeutic effect on the type of aplastic anemia caused by short telomeres,» the authors state in an article in the journal Blood, with Christian Bär among them as the first author, as well as Juan Manuel Povedano.

The variant lies near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.

Understanding the regulation and limitation of the telomerase enzyme holds the promise of reversing telomere shortening and cellular aging with the potential to extend human lifespan and improve the health and wellness of elderly individuals.

By specifically targeting the pause signal that prevents restarting DNA repeat synthesis, telomerase enzymatic function can be supercharged to better stave off telomere length reduction, with the potential to rejuvenate aging human adult stem cells.

Augmenting and regulating telomerase function will have to be performed with precision, walking a narrow line between cell rejuvenation and a heightened risk for cancer development.

With arsenic forcing the production of largely useless telomerase in cell lines that simulate acute promyelocytic leukemia, the chromosomes in cancer cells fuse together, causing the cell death that helps fight the cancer.

In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase.

Now two reports show that, with the help of an enzyme called telomerase, human cells can divide forever in the laboratory without turning cancerous.

The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae — with regular and irregular telomeric sequences, respectively — have now been identified and characterized.

Telomerase slows this down, and with it the aging process.

In this context, telomerase activity can have unfavorable effects: «We found that this enzyme allows cells with aneuploidy to bypass the protective function of telomeres.

When Lin engineered the telomerase - expressing hepatocytes to die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase cells had been killed exhibited much more severe liver scarring than those in which the cells were functional.

Other investigations suggest that telomerase activity that is associated with adult stem cells may reside preferentially in transient amplifying cells, the stem cell daughters that are on the way to commitment and that, in fact, the telomerase in quiescent stem cells is repressed [22,25].

When donor peripheral tissues were mixed with the tissues of a positive control (Hela cells) the HeLa cell telomerase activity decreased (Figure 2D).

Telomerase activity, then, seems to be associated with germinative cells in transition (transient amplifying cells) and cancer cells.

For example, labeling of these cells with stem - like cell associated markers (p63, nestin, and telomerase) have heavily implicated these cells as stem cells [13].

These cells were immortalized by retroviral transduction of the SV40 T antigen and Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T telomerase complex [4], and then termed HMLE (Human Mammary with Large T and TERT).

Methods: Human corneas with attached scleral rims were obtained from eye banks and were assayed for telomerase activity and BrdU (bromodeoxyridine) incorporation to determine, respectively, the presence of a stem - like cell marker and replicative activity.

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

Specific association of human telomerase activity with immortal cells and cancer.

Sadly only a few of these are associated with an sufficiently extensive set of evidence such that responsible human trials are an immediate possibility: myostatin knockout for muscle growth and telomerase gene therapies to offset some of the declines of aging.

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

NOP2 and PPRC1 are involved in ribosomal biogenesis and are coexpressed with DKC1, a gene involved in ribosome biogenesis and also a component of the telomerase ribonucleoprotein enzyme complex.