Sentences with phrase «with therapeutic drugs»

The team also discovered new pockets in the HNF - 4α protein that could be targeted with therapeutic drugs.

Not exact matches

«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».

The internist is equipped to treat the physiological problems and administer Antabuse; the psychologist is trained to do testing through which the alcoholic's therapeutic needs can be evaluated, and he may be trained to do research and psychotherapy; the psychiatrist, being a medical doctor like the internist, can prescribe medication, but his unique skills are in the area of individual and group therapy and their relationship to drug therapies; the social worker may be trained to help the alcoholic work through his marital and vocational problems and do group as well as individual therapy; the social worker may also work with spouses; the pastoral counselor is specially equipped by training to help the alcoholic with his «spiritual» problems as these relate to his sobriety and his interpersonal relationships; he may also be trained to do group and marital counseling; 40.

Nationally recognized, the Relief Nursery stops the cycle of child abuse and neglect with its blend of therapeutic early childhood services and comprehensive family support, including alcohol and drug recovery support services.

The results of this screening of active honeys against pathogenic bacteria has supported the registration of honey as a «Drug» with the Therapeutic Good Administration based on its antimicrobial activity.

In early March, USADA presented the Pacquiao camp with a contract that allowed the testing agency to grant a retroactive therapeutic use exemption (TUE) to either fighter in the event that the fighter tested positive for a prohibited drug.

Clenbuterol, a therapeutic drug first developed for people with breathing disorders such as asthma, is widely used by bodybuilders and athletes.

This is compared with the therapeutic dose of the drug, and the «rate of clearance» of the drug by the baby is also taken into account — the lower the level of clearance, the higher the baby's exposure to the drug.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

In addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug development.

«This could lead to a new therapeutic strategy for treating type 2 diabetes,» says Stanford, whose team believes that the drug could lead to fewer people with adult - onset diabetes becoming dependent on insulin injections.

Once researchers understand the rules for how to get specific shapes with TZPs that also assemble into larger structures, they can design materials with desired functions — for example, a membrane for a battery, a catalyst for a fuel cell, or even a therapeutic drug.

«By administering chemotherapy within this «therapeutic window,» oncologists could apply a lower dose of chemotherapy drugs to patients, with the potential for an improved treatment outcome — all while minimizing drug toxicity to healthy organs,» He said.

Biomedical engineer Elisa Konofagou at Columbia University is pursuing another way to sneak drugs into the brain, by drilling microscopic channels with a high - intensity ultrasound device similar to the therapeutic ultrasound doctors use to dislodge kidney stones.

If these peptides are developed for therapeutic use, the researchers anticipate that they could be used either in stand - alone therapy or together with traditional antibiotics, which would make it more difficult for bacteria to evolve drug resistance.

«This study is particularly interesting from a therapeutic perspective since montelukast is a safe drug with very few side - effects, which means it can be taken over a long period of time,» explains Professor Haeggström.

Much clinical research will be needed to determine whether those drugs are safe over a long period and have therapeutic benefits for people with Down syndrome,» said Sullivan.

The recent growth is driven, experts say, by aging populations and increased life expectancy in the developed world; combination products that couple a medical device with a drug, the device usually acting as a drug - delivery vehicle; miniaturization (via nanotechnology), making medical devices less invasive; and the use of molecular diagnostics to customize therapeutic regimens and to assess individual disease risk.

Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.

Advocates contend that MDMA has therapeutic potential, and several researchers around the world are now administering the drug to patients with post-traumatic stress and other disorders.

University of Calgary researchers including Luchman, Weiss and Dr. Greg Cairncross — director of SACRI, and leader of the Terry Fox Research Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastDrug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastoma.

«What we are trying to do now is understand if we can predict this subgroup through genome sequencing and, perhaps, find a therapeutic opportunity to treat them with anti-inflammatory drugs.»

The authors conclude that recurrence of an atrial tachyarrhythmia was frequent in both groups, and that when offering ablation as a therapeutic option to patients with paroxysmal AF who have not previously received antiarrhythmic drugs, the risks and benefits need to be discussed and treatment strategy individually recommended.

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Scientists say that suggests that by disrupting the recollection of a drug - associated memory — a person one abuses drugs with, a place that one uses drugs at, for example — a therapeutic may be able to break the connection between cues in the environment and the need for drugs.

Explain how the abnormal microenvironment impacts anti-cancer drugs and how manipulating it with antiangiogenics can improve therapeutic outcomes.

In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse.

«Physicians do use the database, but it's not yet common for them to use it for every prescription because it's still lacking a lot of information on pharmaceuticals,» said Lööf, chairman of the Drug Therapeutic Committee at the Centre for Clinical Research in Västerås, which works with local physicians to provide drug therapy strategDrug Therapeutic Committee at the Centre for Clinical Research in Västerås, which works with local physicians to provide drug therapy strategdrug therapy strategies.

The finding that a diagnosis but not psychotic - like experiences is associated with low physical activity may reflect aspects of illness such as low motivation, but may also reflect sedative or other side - effects of therapeutic drugs.

Like other big pharma companies, Pfizer is partnering with academic institutions to share the risk of drug development and take advantage of academic scientists» broad base of knowledge, says Boston - based Anthony Coyle, vice president of the Centers for Therapeutic Innovation (CTI) at Pfizer.

Transport of engineered nano - particles loaded with drugs or bio-molecules to the site of the disease in pathophysiologic states in humans plays a critical role in determining the efficacy of therapeutic management.

Instead of just weight based dosing with empiric dose escalation for symptoms, we propose monitoring the serum drug concentrations and adjusting the dose to achieve a drug concentration within the therapeutic range.»

Implementation of reference pricing was associated with a 7 percent increase in prescriptions filled for the low - price reference drug within its therapeutic class, a 14 percent decrease in average price paid, and a 5 percent increase in consumer cost sharing, the study found.

«This breakthrough could lead to more effective therapies for women with this very common subtype of breast cancer and be the therapeutic target that the drug companies have been waiting for.»

As with all potentially therapeutic drugs, however, caution is required.

«This is the first nanocarrier - drug combination that shows therapeutic effects for three to four months with a single dose.

In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.

This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.

«Targeting this inflammatory pathway with drugs or antibodies could be a new therapeutic strategy to treat worm infections and the associated pathology,» said Meera Nair, an assistant professor of biomedical sciences in the UC Riverside School of Medicine, whose laboratory made the discovery.

«Given the therapeutic potential of the nSMase target, we're now working closely with Drs. Barbara Slusher, Camilo Rojas, Ajit Thomas and colleagues at the Johns Hopkins Drug Discovery facility to identify potent inhibitors of the nSMase enzyme which can be developed for clinical use,» says Haughey.

Most drugs exert their therapeutic effect by binding to a target protein molecule, thereby interfering with the normal function of the protein.

Additionally, ACE910 absorbed into the plasma at a steady rate similar for both Japanese and Caucasian volunteers and remained in the blood with a half - life of four to five weeks, suggesting that the drug's therapeutic effects could be sustained with once - weekly subcutaneous dosing of ACE910.

«If we go back 10 years and ask what is the most important parameter [to developing a therapeutic particle], people would immediately think of the particle's size and then its surface chemistry,» says University of California, Santa Barbara, chemical engineering professor Samir Mitragotri, who develops microscopic particles of different shapes and tests their ability to deliver drugs, but was not associated with DeSimone's study.

With genetically engineered microorganisms, such as bacteria and fungi, playing an increasing role in the green chemistry production of valuable chemical products including therapeutic drugs, advanced biofuels and biodegradable plastics from renewables, Cas9 is emerging as an important genome - editing tool for practitioners of synthetic biology.

One problem with these drugs, however, is that they often inhibit many different targets, which can lead to side effects and complications in therapeutic use.

«If hyperexcitability is the brain network basis for these symptoms, then reducing neuronal excitability with certain drugs that modulate inhibition could be of therapeutic value in these devastating neurodevelopmental disorders.»

«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»

Drug screening Identification of compounds with therapeutic potential for DM1 will be performed through the implementation of large - scale technological resources.

This enables therapeutic antibody drugs to bind with extreme precision — only their target molecule should be an exact match.