Sentences with phrase «with thiol»

Enzymes use beneficial metals for their activity and hold those metals in place with thiol groups.

CDDO - Me reacted with thiol groups as determined by detection of specific adducts by LC - MS (Tables S1 and S2 and Figure S3 in Data S2).

A key test of chemical reactivity is to incubate the compounds with a thiol - containing reductant.

Team leader Jonathan Dimmock, a medicinal chemistry researcher in the U of S College of Pharmacy and Nutrition, explained their compounds work by interacting with thiols, naturally occurring chemicals that perform several roles in cells.

Rather, some of the most effective phytochemicals appear to work via the PRO-oxidant reaction of their quinone metabolites with thiols on the sensor protein Keap1, releasing the transcription regulator Nrf2 into the nucleus to initiate an adaptive stress response.

Not exact matches

To see how a size disparity would affect the crystalline order and the system's physical properties, Olvera de la Cruz and postdoctoral fellow Zhenwei Yao devised a model system of soft particles, such as functionalized nanoparticles with grafted chains including nucleic acids or thiols.

In NHLF cells transfected with siRNA against Nrf2 and subsequently treated with either the thiol - reactive compounds CDDO - Me or HPP - 1014; or the non-reactive compounds CoPP or HPP - 4382, there was a marked reduction in HMOX1 expression.

HPP - 4382 does not have electrophilic properties, as determined by its structure and lack of chemical reactivity with common thiol - containing compounds such as N - acetylcysteine.

As a thiol - containing metabolite, cysteamine is suspected to engage disulfide bridges with target molecules.

Foods high in free thiols may be poorly tolerated by some mercury - affected individuals, particularly if the transsulfuration pathway is compromised, as can occur with molybdenum deficiency.

• «SULPHUR FOODS» This resource (livingnetwork.co.za / chelationnetwork / food / high - sulfur - sulphur - food - list /) explains why some people with mercury toxicity can not tolerate thiols and how to identify thiol intolerance.

They talk about the most important mechanism by which Mercury causes toxicity appears to be Mitochondrial damage via the depletion of Glutathione, coupled with binding to thiol groups, which generate free radicals.