Sentences with phrase «with tropism»
Encapsulated virus (like feline rhinotracheitis virus), opportunistic and low immunogenic activity, with tropism for both respiratory and genital mucous membranes and central nervous system, capable of persisting in a latent status and reactivating at regular intervals.
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These findings represent an important step towards a better understanding of human Leishmania infection, with relevance to parasite drug resistance, pathogenicity, and tissue tropism.
As full length Bk132 Env would not pseudotype on an NL43 HIV core we truncated the cytoplasmic tail of the Envs [49], [50], and conducted tropism testing on NP2 cell lines expressing CD4 with either CCR5 or CXCR4.
In addition to the viral vector itself, each virus particle comprises a viral envelope that fuses with the target cell's membrane and determines target cell specificity or tropism (see Viruses of a Feather Infect Together, below), and a protein capsid that encloses the genetic material.
Pseudotyping is the process of producing viruses with foreign envelope proteins and is frequently used to generate viruses with altered cell tropism [Cronin et al., 2006].
We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism.
The MDA - MB - 231 — derived 1833 cell line, which is characterized by enhanced bone - specific metastasis compared to the parental cell line or cell lines with increased tropism to lung and brain, showed increased abundance of ABL1 and ABL2 (fig.
To directly evaluate the relationship between ABL family kinases and metastasis, we analyzed ABL1 and ABL2 protein abundance in MDA - MB - 231 — derived breast cancer cell lines with different organ metastasis tropisms (19).
Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].
Once this transformation or change in tropism (preference) has occurred, the body's immune system runs amuck with severe inflammation attacking cells that harbor the virus (liberation of pro-inflammatory cytokines).