Glutamate dehydrogenase 1 (GLUD1) and SLC25A13 have pivotal roles under glucose - deprived conditions and are associated
with tumor aggressiveness and colorectal cancer prognosis.
«GLUD1 and SLC25A13 were associated
with tumor aggressiveness and poorer prognosis of colorectal cancer.
GLUD1 and SLC25A13 have pivotal roles in nutritional stress and are associated
with tumor aggressiveness and poorer prognosis of colorectal cancer.
Not exact matches
According to this theory,
tumor cells tend to «forget» the tissue from which they originated as the disease progresses, acquiring an undifferentiated phenotype associated
with heightened
aggressiveness and treatment resistance.
A form of genetic variation, called differential RNA splicing, may have a role in
tumor aggressiveness and drug resistance in African American men
with prostate cancer.
«FDG PET shows
tumor DNA levels in blood are linked to NSCLC
aggressiveness: Insights derived from FDG PET could improve treatment selection for patients
with advanced non-small cell lung cancer.»
Italian researches have demonstrated a better way of determining the
aggressiveness of
tumors in patients
with advanced non-small cell lung cancer (NSCLC).
In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free
tumor DNA circulating in the bloodstream correlates
with tumor metabolism (linked to cancer
aggressiveness), not
tumor burden (amount of cancer in the body).
Identification of genes associated
with local
aggressiveness and metastatic behavior in soft tissue
tumors.
Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects
with potential oncogenic properties including increased
tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].
Reproductive disorders such as pyometra, mammary
tumors, testicular cancer, ovarian cancer, and prostate cancer are also reduced / prevented
with neutering (reviewed in [2]-RRB- although neutering has been associated
with increased risk or
aggressiveness of prostatic cancer [3 — 5].