Sentences with phrase «with tumor cell invasion»
The epithelial - to - mesenchymal transition (EMT) and the reverse process (the mesenchymal - to - epithelial transition [MET]-RRB- have been shown to be associated with tumor cell invasion and metastasis in different carcinomas.
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A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.
«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.
Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.
Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.
Metastasis begins with the invasion of tumor cells into the stroma and migration toward the blood stream.
This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.
Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).