In addition, while cfDNA correlated
with tumor metabolism, no association was found with circulating tumor cells (CTCs).
In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates
with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the body).
This study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with chemotherapy found direct correlation of the amount of cfDNA
with tumor metabolism (based on PET - derived parameters), but not with metabolic tumor volume.
Not exact matches
With the
tumor in this vulnerable state, the researchers strike again by shutting down the cell's ability to mitigate the toxic stew it creates from its own deranged
metabolism.
Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign
tumors on the uterus called uterine fibroids than women
with low levels of the hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology &
Metabolism.
Results published by the Altieri laboratory demonstrated that these molecules accumulate in mitochondria of
tumor cells, where they physically interact
with components of the organelle permeability transition as well as
with a number of regulators of bioenergetics, including the control of protein production, lipid
metabolism and ATP generation.
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