Sentences with phrase «with tumor metastasis»

Analysis of liver tumor samples from patients showed that NRF2 expression correlated with tumor metastasis.

Not exact matches

After adjusting for age, tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a recurrence.

Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often associated with a gloomy prognosis.

«Surgery is the main treatment option for patients with most solid tumors, but recurrence and metastasis remain significant problems,» says study senior author Michael Goldberg, PhD, assistant professor at Dana - Farber and Harvard Medical School.

Excessive adipose or fat tissue, for example, raises circulating levels of estrogen, which is associated with tumor creation and metastasis.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

The tumor - cell survival factors uncovered by this study might one day be targeted with drugs to further diminish people's risk of metastasis.

With these in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer cell growth, metastasis and ability of the tumors to recur after radiation therapy.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

They detected the presence of an enzyme that can induce tumor metastasis, MMP - 2 (matrix metalloproteinase - 2) in mice with cancer.

«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.

Researchers working in mice with cancer now find that some of these drugs can spur the metastasis of existing tumors, including colon and liver cancer.

So a drug that blocks DDR2 from binding with collagen won't destroy the tumor, but it could inhibit the invasion of these tumors into surrounding tissue and reduce metastasis.

His laboratory at the German Cancer Research Center in Heidelberg and at the Medical Faculty Mannheim of Heidelberg University is studying the mechanisms of metastasis with the goal to develop more gentle supportive adjuvant therapies for tumor patients without detectable metastases following surgery of the primary tumor.

Many tumor patients are consequently treated with chemotherapy after surgery to fight metastasis.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

Pandolfi and colleagues sought to identify an additional tumor suppressing gene or pathway that may work in concert with PTEN to drive metastasis.

Record mice with tumors that are large and form close to the neck as these may give metastasis more efficiently.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

The inflammatory cytokine TNFa cooperates with Ras in elevating metastasis and turns WT - Ras to a tumor - promoting entity in MCF - 7 cells.

[31] Animal brain metastasis models have demonstrated significant tumor response and improved survival with this compound.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.

The epithelial - to - mesenchymal transition (EMT) and the reverse process (the mesenchymal - to - epithelial transition [MET]-RRB- have been shown to be associated with tumor cell invasion and metastasis in different carcinomas.

A great deal of evidence has now been amassed that stromal cell senescence plays an important role in laying the groundwork for tumor metastasis, promoting cell proliferation with inflammatory cytokines, encouraging angiogenesis, and degrading the tumor - suppressive action of an intact extracellular matrix.

They are associated with tumor recurrence and metastasis, the lethal spreading of cancer to other organs.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

Gb3 expression was detected independent of type (diffuse / intestinal), and was negatively correlated to increasing tumor - node - metastasis stages (P = 0.0385), as well as with markers for senescence.

Various disease states are associated with deregulation of how cells move and change shape, including notably tumor initiation and cancer cell metastasis.

I am a Morgridge Postdoctoral Fellow working jointly with Kevin Eliceiri, Morgridge Institute for Research and LOCI; Patricia Keely, Cell and Regenerative Biology; and Sean Fain, Medical Physics; in multiscale imaging — including fluorescence lifetime imaging microscopy and magnetic resonance imaging of tumor metabolic signatures — to predict cancer metastasis.

Metastasis begins with the invasion of tumor cells into the stroma and migration toward the blood stream.

Bennett EE, Angelov A, Vogelbaum MA, Barnett GH, Chao ST, Murphy ES, Yu JS, Suh JH, Jia XJ, Glen HJ, Ahluwalia MS, Mohammadi, The Prognostic Role of Tumor Volume in the Outcome of Patients with Single Brain Metastasis After Stereotactic Radiosurgery.

Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.

The idea was to identify genes that were metastasis determinants by correlating gene expression with some kind of invasion assay that measured tumor progression.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

With curcumin, the tumor cells synthesize smaller quantities of cytokines that promote metastasis.

Prognosis for dogs with adrenal - dependent Cushing's due to a tumor is good to excellent with complete surgical excision of adrenal tumors without metastasis.

In cats with a thyroid carcinoma, extension or metastasis to the thoracic cavity is common, so physical palpation alone will grossly underestimate the full extent of these malignant tumors.

In human medicine, staging (looking for metastasis) for similar head and neck tumors regularly includes the functional imaging positron emission tomography (PET) combined with computed tomography (CT).

Spread to other internal organs (metastasis) is possible with some types, particularly the larger tumors.

There are three grades: Grade I tumors are easily identified and rarely metastasize; Grade II tumors have intermediate differentiation and extend deeper into the underlying tissues and about 20 percent will spread or metastasize; Grade III tumors are poorly differentiated and behave aggressively with an 80 percent or higher chance of metastasis.

Canine osteosarcoma (cOSA), the most common primary bone cancer in dogs, is a highly aggressive tumor with an estimated spread (or metastasis) rate of approximately 90 %.

Less than 5 % of dogs with long bone tumors have radiographically detectable metastasis to the lungs at the time of diagnosis.

Even with the standard - of - care therapy of amputation and chemotherapy, the prognosis is poor, with most dogs dying due to tumor spread (metastasis) within one year, and less than 20 % surviving to 2 years following diagnosis.

Dogs with benign tumors usually do not require more than the removal of the tumor as treatment, However, cases with malignant tumors should be staged (evaluated for metastasis).

However, large tumors are associated with poor prognosis due to either the inability to achieve a complete surgical removal and / or due to metastasis to lungs and lymph nodes by the time of diagnosis.

Dr. Watanabe is from São Paulo, Brazil, and her project was entitled «Malignant Gastrointestinal Stromal Tumor with Transplantation Metastasis in a Horse.

Prognosis of patients with this disease depends on multiple factors, the most commonly cited including: presence of metastasis (negative), elevated alkaline phosphatase (negative), large tumor size (negative), humerus location (negative), treatment chosen (dogs receiving amputation and chemotherapy have improved survival times over dogs receiving amputation alone) 1.

A few dogs are diagnosed with advanced metastasis (tumors that have spread to elsewhere in the body, such as the lungs and lymph nodes) and might be feeling ill from their tumors when they come for treatment.