Sentences with phrase «with tumor stages»

Eligible patients presented with tumor stages of T1c to T3a, prostate - specific androgen (PSA) levels of 20 or below, and one or two of three risk factors: stage T3a, a Gleason tumor score of seven or higher, or a PSA level greater than 10.

Not exact matches

My sweet little nephew who is 5 was just diagnosed with a stage 4 brain tumor.

Just weeks after he was named chief medical officer at the Roswell Park Cancer Institute, Dr. Boris Kuvshinoff was diagnosed with an inoperable late - stage tumor in the nasal cavity above his mouth and became a patient there.

His outlook began to change when a routine colon screening detected that he had been living with stage three cancerous tumors.

After adjusting for age, tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a recurrence.

The scientists recommend that people with advanced - stage fibrolamellar hepatocellular carcinoma, which mostly affects teenagers and young adults, receive regular neuroimaging scans because of the tumor's apparent ability to metastasize to the brain.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

An early - stage clinical study by another institution, published in the Lancet Oncology in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

The authors propose that «patients with high serum SCC levels, vascular invasion or pleural invasion should have their tumor stage upgraded in order to reflect the clear differences in survival.

«By understanding what causes malignant transformation we can determine what can be done for patients with benign tumors to suppress them before they reach the malignant stage,» Alman said.

For example, researchers can grow spheroids that mimic early - stage tumors, then treat them with candidate chemotherapies and watch for the spheroids to stop growing or start shrinking.

Nana - Sinkam and his colleagues examined lung - tumor samples from 81 patients with stage - 1 nonsmall - cell lung cancer and tumor - cell lines.

Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1.

For patients with a stage T3 tumor (larger than 4 cm with minimal extension beyond the thyroid), surgeons and pathologists should be testing at least 18 lymph nodes.

For patients with a stage T2 tumor (larger than 2 cm but no larger than 4 cm), surgeons and pathologists should test at least 9 lymph nodes around the tumor.

By the Duke researchers» calculations, surgeons operating on patients with a stage T1b tumor (more than 1 cm, but less than 2 cm at its widest point) can be 90 percent sure they have contained the cancer if they remove 6 lymph nodes around the tumor that test negative for the disease.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Locally advanced pancreatic cancer has the lowest survival rate of any solid tumor, with a cumulative five - year survival rate of only 4 percent for all stages of disease.

«Pancreatic cancer is a disease with a poor prognosis, mainly because of the inability to detect the tumor at an early stage, its high potential for early dissemination, and its relatively poor sensitivity to chemotherapy or radiation therapy,» according to background information in the article.

Scientists at Georgia State University (GSU) with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have designed an imaging technique to detect early - stage liver tumors, and have proven it successful in mice.

Women with Stage III ovarian cancer given a combination of intravenous and intraperitoneal chemotherapy following surgical debulking of tumor had a median survival nearly 16 months longer than women who received IV chemotherapy alone, according to a study published conducted by the Gynecologic Oncology Group (GOG), a National Cancer Institute - supported research network, in the January 5, 2006 issue of the New England Journal of Medicine.

«I want to find those early - stage tumors, and I want to increase the survival of patients with ovarian cancer.»

Levels of circulating tumor DNA (ctDNA) predicted worse outcomes including relapse and survival in patients with resected stage II / III melanoma, according to the results of a study published in Annals of Oncology.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

Women with stage 1 tumors (in whom survival is greater than 95 % after comprehensive surgery), do not generally need to consider clinical trials.

Pramod Srivastava, Giorgio Parmiani, and colleagues report that immunization with autologous tumor - derived gp96 - peptide complexes elicits tumor regression in stage IV melanoma patients, without any immunization - related adverse events.

«Our data suggest that early - stage HER2 - positive breast cancers treated with neoadjuvant combination docetaxel, carboplatin, and trastuzumab with or without pertuzumab demonstrate tumor immune microenvironment phenotype changes,» the authors concluded.

Among married patients studied, almost 47 percent had the smallest, earliest - stage tumors compared with 43... -LSB-...]

The researchers found that non-Hispanic white women were more likely to have smaller tumors, and more likely to have the less - aggressive HR + / HER2 - subtype of breast cancer, compared with African - American women, who were more likely to have large tumors, more likely to have the aggressive triple - negative breast cancer, and 40 to 70 percent more likely to be diagnosed at stage 4 of all subtypes of breast cancer.

The morphological assessment of the differentiation degree in breast cancer has been provided useful prognostic information and the histological grade forms part of the multifactor Nottingham prognostic index together with tumor size and lymph node stage, which is used to assure individual patient for proper therapy [17].

About 40 percent of the young cancer patients were diagnosed with what's known as stage two tumors, when cancer has spread to lymph nodes surrounding the breast while just 34 percent of older women were diagnosed when cancer had reached stage two.

(PHILADELPHIA)-- The most common type of lung cancer, non-small cell lung cancer (NSCLC), continues to be difficult to treat, with five year survival rates of about 36 percent for stage 3A tumors.

Patients with stage - IV cancer with one to five distant metastases and no tumors bigger than 10 centimeters (about four inches) in diameter were eligible to participate in the study either before or after chemotherapy treatment.

With the knowledge that the HOXA9 promoter is methylated in stage I tumors, Robles, Lissa, and team used ddPCR technology to analyze HOXA9 promoter methylation in formalin - fixed, paraffin - embedded tumor specimens.

Patients, especially those with larger tumors, who undergo thoracoscopic resections might have improved cancer specific survival compared with those undergoing SABR for early stage non-small lung cancer

identify disease in its earliest stages and determine the exact location of a tumor, often before symptoms occur or abnormalities can be detected with other diagnostic tests

We further restricted the study cohort to those who had a stage I (T1 or T2, N0, M0) cancer, with tumor size ≤ 5 cm.

Gb3 expression was detected independent of type (diffuse / intestinal), and was negatively correlated to increasing tumor - node - metastasis stages (P = 0.0385), as well as with markers for senescence.

DNA Detectives Find Genetic Markers for Lung Cancers Most Likely to Recur Researchers at the Johns Hopkins Kimmel Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early - stage lung cancers that look like good predictors of which of these cancers are more likely to recur.

Cryoablation — killing cancer cells with extreme cold — is a promising treatment for small, early - stage breast tumors.

Expression profiling of microRNA and other short or long non-coding RNAs in human tumors has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment.

Dr. Lee: Most people with bladder cancer (around 70 %) are initially diagnosed with early stage disease, meaning that their tumor is not growing deeply into the wall of the bladder.

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

There was still a chance of early stage cancer, but that was minor compared with a full - blown tumor.

For example, a person with stage 1 colorectal cancer may be assigned a grade of T1, N0, M0, meaning that the tumor may have grown into one of the muscle layers in the gastrointestinal tract but hasn't spread to nearby lymph nodes or other, more distant areas of the body.

Researchers found lower vitamin D levels in patients with advanced - stage tumors and the lowest levels in premenopausal women with triple - negative cancer.