Sentences with phrase «with tumor tissue»

Not exact matches

The surgeons removed a softball - sized tumor along with skin and muscle tissue surrounding it.

A woman with previous breast surgery can get mastitis (infection of the breast tissues), galactocele formation (a milk filled tumor in your breast) and even galactorrhea (lactation that occurs without the occurrence of pregnancy or childbirth).

Every time I had mastitis and a clogged duct, the flare up permanently damaged my milk ducts, filling them with so much scar tissue that it was like I had a tumor in my right breast.

Turns out, Every time I had mastitis and a clogged duct, the flare up permanently damaged my milk ducts, filling them with so much scar tissue that it was like I had a tumor in my right breast.

Each factor involved in the tumor response — whether it is the speed with which chemotherapeutic drugs reach the tissue or the degree to which cells signal each other to grow — is characterized by a mathematical equation that captures its essence.

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

They discovered that YAP1 is present at higher levels and interacts with OCT4 more in primary and metastatic lung tumors than normal tissue.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

But its images can not distinguish malignant tumors from benign growths filled with harmless breast tissue.

Excessive adipose or fat tissue, for example, raises circulating levels of estrogen, which is associated with tumor creation and metastasis.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

The investigators found that when working through an environment with no pre-existing tracks, tumor cells had to actively stick to the tissue, break it down and then move themselves forward.

According to this theory, tumor cells tend to «forget» the tissue from which they originated as the disease progresses, acquiring an undifferentiated phenotype associated with heightened aggressiveness and treatment resistance.

Plasma samples of patients with NSCLC is a less invasive method and has been used as surrogate tumor tissues for detecting genetic alterations.

The investigators looked at 4,278 tumor samples from a tissue repository of patients with GI tract cancers.

Of the 104 screened patients, 102 enrolled with 91 (89 percent) having adequate tumor tissue to complete sequencing.

With mammography, radiologists use x-rays to spot the dense tissue and tiny calcium deposits in breast tumors.

Sharma had developed a new method for studying how tumors with different characteristics respond to different immunotherapies: She would treat patients before their growths were surgically removed, then analyze the tissue in her lab.

This technique is able to distinguish cancer cell lines with differing metabolic activities and reveals heterogeneous uptake patterns in neurons, mouse brain tissues and tumor tissues with clear cell - to - cell variations.

The tissues were grown on a 3D gelatin sponge, and two portions of the same tumor were treated with either cabazitaxel or docetaxel.

Tumors and dense breast tissue can both appear white on a mammogram, making tumors indistinguishable from background tissue in women with dense brTumors and dense breast tissue can both appear white on a mammogram, making tumors indistinguishable from background tissue in women with dense brtumors indistinguishable from background tissue in women with dense breasts.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

EGFR tyrosine kinase inhibitor (TKI) therapy is approved for EGFR activating mutation positive patients with advanced NSCLC, but the standard for determining mutation status is with DNA derived directly from tumor tissue, which can be limited or not available.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

But working with human smooth muscle cells isolated and grown from the healthy parts of airway tissue surrounding excised tumors, Benjamin Kalbe and his colleagues applied a large number of odor molecules and watched two of them activate the muscle cells.

For the study, researchers investigated tissue samples from 297 people with brain tumors.

Many tumors spread: Single cancer cells migrate with blood flow through the body before they settle in new tissue.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Analysis of images showed that the contrast used by the research team bound almost exclusively to the fibrin - fibronectin complexes, producing a strong and prolonged image enhancement of micrometastases and tumors compared with normal tissue.

But Epigenomics plans to set up a proprietary database on differences between healthy and diseased tissues to flag, for example, patterns associated with tumors.

Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.

The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast cancer patients — including both primary tumors that had not spread from the breast to other body sites, and highly aggressive, metastatic tumors.

Previous cancer studies had shown that by injecting tumors with magnetic nanoparticles made of iron oxide — «essentially rust, with well - tuned magnetic properties,» Anikeeva says — then exposing them to rapidly alternating magnetic fields, excited nanoparticles can be used to heat and destroy cancer tumors while leaving surrounding, healthy tissue intact.

Gartner's group plans to use the technique to investigate what cellular or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize, invading other parts of the body and threatening the life of the patient.

Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

Researchers identified 1,661 differentially expressed gene features between tumors and airways compared with normal lung tissue.

Using a very sensitive DNA analysis technique that can also be employed when only very small amounts of DNA from old tissue are available, the researchers could compare the two current cell lines with the tumor from which the cell line was established.

Keytruda is the first approved drug that targets tumors with specific biomarkers, rather than based solely on their tissue origin (i.e. breast, lung, or colon).

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Together with veterinarians they collected tumors and healthy control tissue from family dogs.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

So a drug that blocks DDR2 from binding with collagen won't destroy the tumor, but it could inhibit the invasion of these tumors into surrounding tissue and reduce metastasis.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

Surgeons will monitor a traffic light - like video display as they cut, he explains, with red indicating tumor cells, green healthy tissue, and yellow something in between.

She wonders, however, how useful the tool will be to surgeons, who would ideally have a complete image of the tumor margins before they cut into tissue, instead of having to feel out the tumor's edges by measuring single points with the iKnife.

The biopsy of his primary tumor pointed to treatment with anti-HER2 therapy (Herceptin), but tissue from the metastatic biopsy, as well as cfDNA analysis, was negative for HER2 and positive for anti-epidermal growth factor receptor (EGFR) therapy (ABT - 806).

«In our practice, we recommend that all patients with baseline EGFR T790M identified in their lung tumor tissue be referred to clinical genetics to discuss EGFR T790M germline testing.

This approach allows us to detect, with high confidence, changes in circulating tumor DNA across a large part of the genome without information from tumor tissue,» said Dr. Razavi.