Sentences with phrase «with tumor viruses»

After two years of post-graduate studies at the Max Planck Institute for Biochemistry in Munich, Dr. Jaenisch set his sights on a postdoctoral position in the United States, and joined Arnold Levine at Princeton University to work with tumor viruses in mammalian systems.

Not exact matches

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

«If we could load these virus shells with a different cargo, say a drug, and target it to a particular place in the body, such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing side effects,» Lawrence said.

To bring the wrath of the immune system down on tumors, researchers have tried shooting them up with a variety of molecules and viruses.

Dr. Cripe and his colleagues at The Ohio State University, the University of Pittsburgh School of Medicine and Cincinnati Children's Hospital Medical Center tested how well the oncolytic viral therapy — a cancer - killing form of the herpes simplex virus, called oHSV — infected and killed tumor cells in mice with and without a healthy immune system.

A team led by neuroscientist Khalid Shah, MS, PhD, who recently demonstrated the value of stem cells loaded with cancer - killing herpes viruses, now has a way to genetically engineer stem cells so that they can produce and secrete tumor - killing toxins.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

«Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing tumor cells.»

The Genomics Facility also is working with other teams studying mutations in bladder cancer tumors; genetic mechanisms of sickle cell disease; viruses in Lake Michigan; and many other projects.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune celWith respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune celwith an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

In collaboration with Pedro Romero, Vincenzo Cerundolo and colleagues demonstrate that, unlike virus - specific CTLs, the highest frequency of tumor - specific CTLs can be found in tumor - infiltrated lymph nodes.

Magnus Essand and Justyna Leja at SciLifeLab / Uppsala University has together with their colleagues developed a new treatment for tumors, using viruses.

Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.

In this case, they would target proteins associated with the Epstein Barr virus, which the tumors would express.

Mice injected with a strain of the Zika virus lived longer and were measured to have smaller tumors than the control group, which was injected with saltwater.

JJ Miranda, PhD, reported that certain drugs affect genes in tumor cells infected with the Epstein - Barr Virus.

Trautmann L, Labarrière N, Jotereau F, Karanikas V, Gervois N, Connerotte T, Coulie P, Bonneville M. Dominant TCR Va usage by virus and tumor reactive T cells with wide affinity ranges for their specific antigens.

I am currently working with Zika virus and how it affects the T cell response and T cell signaling through tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in specific mouse model systems.

Turnstone's therapeutic platform is a first - in - class, tumor - targeted oncolytic vaccine that combines potent tumor - killing effects of oncolytic viruses with the benefits of a cancer vaccine that harnesses the patient's own immune system to fight disease in a sustainable manner.

Effector and target modules together form a novel platform which allows us to engage target cells (e.g. tumor cells, virus infected cells) directly with immune effector cells.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

Many viruses, bacteria, parasites and tumor cells have poor tolerance to heat compared to normal healthy cells and are easily killed with near infrared saunas.

LEUKOCELL 2 is a multiple viral antigen vaccine for vaccination of healthy cats 9 weeks of age or older as an aid in preventing persistent viremia, lymphoid tumors caused by feline leukemia virus (FeLV) and diseases associated with FeLV infection.

A beautiful, thick blue oil - Blue Cypress is reported to have wonderful promise in use with viruses, warts, tumors and more.

Neurosurgeons from the University of Alabama at Birmingham are partnering with veterinary universities to conduct the first immunotherapy study for brain tumors in dogs using an oncolytic herpes simplex virus.

The University of Alabama at Birmingham (UAB) is partnering with veterinary universities to conduct the first immunotherapy study for brain tumors in dogs using an oncolytic herpes simplex virus known as M032.

Dogs with any cancer (except hemangiosarcoma and mast cell tumor) might be eligible for a clinical trial to define the optimal dose and schedule for an oncolytic virus treatment (VSV - IFNβ - NIS).