Sentences with phrase «with ubiquitination»
In humans, there are about 100 proteins associated with ubiquitination, the process by which a protein labelled with ubiquitin is removed from the cell by specific cell machinery known as the proteosome.
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Analysis was carried out using purified c - ABL and the substrate peptide, EAIYAAPFAKKK, in association with the MRC Unit on Phosphorylation and Ubiquitination, University of Dundee, Scotland.
RIPK2 is activated via tyrosine (Y)(pY474) and serine (S)(pS176) phosphorylation and ubiquitination events to allow for associations with downstream components.
This effect is mediated by an enhanced interaction of H2AX with the E3 ubiquitin ligase RNF168, which is associated with H2AX poly - ubiquitination and promotes its degradation by the proteasome.
Initial empirical testing for c - ABL was carried out via an in vitro kinase approach with purified recombinant kinases at the MRC Protein Phosphorylation and Ubiquitination Unit in Dundee, Scotland.
Ubiquitination of Oct4 by a specific E3 ubiquitin ligase, with resultant proteasomal degradation, has previously been described [24].
The latest publication of the Robinson - lab (Lancaster University, UK) in collaboration with the Ettema - lab is now available online at Nature Communications, regarding the «Functional reconstruction of a eukaryotic - like E1 / E2 / (RING) E3 ubiquitylation cascade from an uncultured archaeon» — the first time that the ubiquitination cascade has been demonstrated outside of eukaryotes.