Sentences with phrase «with uncertain effects»

Water demand looks set to rise and, together with the uncertain effects of future climate change, this puts water planners under considerable pressure.

The new legislation would reduce this requirement after 2021, with uncertain effects on the price of SRECs.

PUZZLE PLANT After bursting on the scene in the 1960s, marijuana remains a substance with uncertain effects on mental health and medical conditions.

Not exact matches

RALEIGH, N.C. — A public water utility studied what it was serving to its 200,000 North Carolina customers and found it contained multiple unregulated industrial chemicals with uncertain health effects, including some substances that university researchers didn't know existed, legislators learned Thursday.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Furthermore, we would expect any rises in global bond yields to be at least partly imported into Canada — with possible implications for the Canadian dollar — and with an uncertain net effect on our economy.

To cap it all those crude rocket with uncertain and devastating effect, courtesy to those who are behind the supply.

On the other hand, advanced maternal age is associated with a more stable family environment, higher socio - economic position, higher income and better living conditions, as well as better parenting practices, [14] but it is more or less uncertain whether these entities are effects of advanced maternal age, are contributors to advanced maternal age, or common effects of a certain state such as personality type.

The results for breast cancer are in line with previous research, but the true effect of alcohol on risk of ischaemic heart disease remains uncertain, say the editorial authors.

He says the law may not effect much change in areas with strong pockets of vaccine - refusing parents, but he hopes more of the parents feeling uncertain about immunization will realize the benefits after getting accurate information from a health care professional.

With some frequency, this technique leaves new mutations in its wake with uncertain side effeWith some frequency, this technique leaves new mutations in its wake with uncertain side effewith uncertain side effects.

Among the most uncertain elements in climate models are the effects of aerosols and their interactions with clouds — just the things involved in albedo modification — she says.

She added: «Some doctors have been hesitant to prescribe statins in patients with very low LDL - C because of uncertain benefit and the risk of side effects with statins.

Cortisone injections should be used with caution, as many patients experience a relapse, and the long - term effects are uncertain.

Although prescribing this approach with the intent of helping to prevent myopia would appear to have no risk, parents should understand that the magnitude of the effect is likely to be small and the durability is uncertain.»

Climate change effects on the geographical distribution and incidence of vector - borne diseases in other countries where these diseases are already found can also affect North Americans, especially as a result of increasing trade with, and travel to, tropical and subtropical areas.63, 197 Whether climate change in the U.S. will increase the chances of domestically acquiring diseases such as dengue fever is uncertain, due to vector - control efforts and lifestyle factors, such as time spent indoors, that reduce human - insect contact.

Similar effects were observed in another one, where people with a high fat, low carb breakfast reported feeling less tense, not as uncertain, drowsy or muddled, compared to other participants with different types of breakfast.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Coogler's facility with staging and shaping the fight scenes is quite good, though he has a tendency to flip between hand - held «realism» and a more classical approach to uncertain effect.

Feig, who lets the actors run free with the material before that central story kicks into gear, seems uncertain of how to balance the humor with the plotting and effects (which are fine until the climax, when all of the action looks like its set against a digital fog machine).

The study also uses survey data from developers to gauge the effect of timeline uncertainty in each municipality, with responses measured on a five - point scale from (1.0) «encourages development» to (5.0) «would not pursue development due to uncertain approval timelines.»

As crowds gathered around the installation, the effect on viewers of the gaze of his subjects — families and strangers with uncertain futures peering out across time and geography — was both poignant and chilling.

Secondly it seems really important to me for the wider discussion (beyond just the topic of this thread) that some estimate of the «uncertain» potentiating effect of predicted temperature increases be provided and integrated with the climate sensitivity predictions so that we can have a statement that actually attempts to predict possible real world temperature increases.

Now, certainly whether these effects will occur is uncertain, but the proper way to deal with this in risk mitigation is to scale effort by the potential cost of the adverse event multiplied by its probability.

In short, Lindzen's argument is that the radiative forcing from aerosols is highly uncertain with large error bars, and that they have both cooling (mainly by scattering sunlight and seeding clouds) and warming (mainly by black carbon darkening the Earth's surface and reducing its reflectivity) effects.

While it is impossible to know what decisions are made in the development process of each model, it seems plausible that choices are made based on agreement with observations as to what parameterizations are used, what forcing datasets are selected, or whether an uncertain forcing (e.g. mineral dust, land use) or feedback (indirect aerosol effect) is incorporated or not.

And anyways, is the solar uncertainty (we understand the sign) really so much more greater than that associated with the effects of clouds on climate (see my recent post The cloud climate conundrum), where even the sign of the feedback is uncertain and the magnitude of cloud forcing swamps greenhouse gas radiative forcings.

The effects of this marked shift in westerly winds are already being seen today, triggering warm and salty water to be drawn up from the deep ocean, melting large sections of the Antarctic ice sheet with unknown consequences for future sea level rise while the ability of the Antarctic Circumpolar Current to soak up heat and carbon from the atmosphere remains deeply uncertain.

E.g., research assumes greenhouse gas emissions cause warming without explicitly stating humans are the cause»... carbon sequestration in soil is important for mitigating global climate change» (4a) No position Does not address or mention the cause of global warming (4b) Uncertain Expresses position that human's role on recent global warming is uncertain / undefined «While the extent of human - induced global warming is inconclusive...» (5) Implicit rejection Implies humans have had a minimal impact on global warming without saying so explicitly E.g., proposing a natural mechanism is the main cause of global warming»... anywhere from a major portion to all of the warming of the 20th century could plausibly result from natural causes according to these results» (6) Explicit rejection without quantification Explicitly minimizes or rejects that humans are causing global warming»... the global temperature record provides little support for the catastrophic view of the greenhouse effect» (7) Explicit rejection with quantification Explicitly states that humans are causing less than half of global warming «The human contribution to the CO2 content in the atmosphere and the increase in temperature is negligible in comparison with other sources of carbon dioxide emission»»

The direct CO2 - fertilisation impact and warming effect of rising atmospheric CO2 have contrasting effects on their dominant functional types (trees and C3 grasses may benefit from rising CO2 but not from warming; C4 grasses may benefit from warming, but not from CO2 - fertilisation), with uncertain, non-linear and rapid changes in ecosystem structure and carbon stocks likely.

To which the response will be: Yes but the aerosol components are so uncertain and tunable that we will shortly demonstrate how a strong aerosol cooling effect is consistent with a lack of mid-century aerosol cooling, so there's no need to doubt the hypothesis of strong CO2 warming.

How can such decisions be rationalised with the continued application of the «selling arrangement», the «insignificant» effects criterion, and the concept of effects «too uncertain and indirect»?

If you are uncertain that your salary history or requirements are a close match, use language in your cover letter to the effect that, with regard to salary, you are sure the employer has a fair compensation program, and that your primary interest is in this company and opportunity.

An especially powerful message to be drawn from this is that without intergovernmental cooperation, information exchange and coordination, the States and Territories, in particular, will be left uncertain as to how to co-ordinate their responses with those of the Commonwealth in order to maximise effect and efficiency.

Multiple factors reportedly increase the risk of suicide.44 - 49 Substance abuse has repeatedly been associated with suicidal behaviors, and depression has as well.1,50 - 62 Moreover, previous reports from the ACE Study have demonstrated strong, graded relationships between the number of adverse childhood experiences and the risk of alcohol or illicit substance abuse and depressive disorders.23, 24,28 Although a temporal relationship between the onset of substance abuse or depressive disorders and lifetime suicide attempts in the ACE Study cohort is uncertain, our analysis of the potential mediating effects of these known risk factors provides evidence that for some persons, adverse childhood experiences play a role in the development of substance abuse or depression.