Sentences with phrase «with uncertain numbers»

Time with the students would be scarce, with an uncertain number of afternoons and break times each week.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Further ahead, the outlook is more uncertain, with the Access Economics Investment Monitor indicating a fall in the number of building projects proceeding from the planning stages.

Aaron Ramsey has revealed that he is uncertain of his first - team spot at Arsenal this season, with a number of team - mates excelling currently.

A trophy-less season, which cost Carlo Ancelotti his job [The Independent], filled with whistles and catcalls from the Real faithful has left the futures of a number of the Spanish giants» superstars uncertain.

Egypt were firmly second - best throughout Wednesday's semifinal, with El Hadary making a number of useful saves before the shoot - out despite looking uncertain with crosses into the box.

Yes, it's an uncertain number and people can choose to pay more or less tax so it doesn't feel like a tax rise to them (although they may be hit with unexpected tax bill).

C. ambiguus, as the name indicates, has attributes of a number of family members, making its evolutionary relationships with the group uncertain.

We came up with numbers that business as usual would give you: losses, averaged over space, over time and uncertain outcomes, of around 5 percent of global gross domestic product and upwards, probably substantially more than 5 percent of GDP.

However, in the absence of lithium, occurrence of neuronogenesis in the spinal cord of G93A mice is uncertain, and, when occurring (27), it does not produce a net increase in neuron number compared with controls.

If the lack of places filled in computing is concerning, the number in design and technology is cause for alarm: with less than half the number of trainees required for two years in a row, it is uncertain for how much longer the subject is viable.

With Maemo, Nokia's smartphone future seems a lot brighter than it is with Symbian OS, but despite the obvious potential, the number (and quality) of applications is still uncertain right With Maemo, Nokia's smartphone future seems a lot brighter than it is with Symbian OS, but despite the obvious potential, the number (and quality) of applications is still uncertain right with Symbian OS, but despite the obvious potential, the number (and quality) of applications is still uncertain right now.

In the context of parametric uncertainty for the bias corrections, the determination of uncertainty is associated with a number of underlying assumptions that are uncertain in themselves.

I am of the school of playing along with the uncertainty and if we are uncertain about the numbers, then perhaps nature is as well.

Finance is the most uncertain element and the number one impediment to making progress on the ground in countries with high deforestation rates.

While I'm sure a number of folks will disagree with me on what is spurious vs. substantive, I think it would be useful to outline which parts of the debate I feel are relatively certain, are somewhat uncertain, and quite uncertain.

Now as an uncertain period comes with SegWit and the Bitcoin Cash (BCC) fork at the end of July and into August, clients look to have taken the opportunity to move bitcoin off exchange as evidenced by the numbers.

Multiple factors reportedly increase the risk of suicide.44 - 49 Substance abuse has repeatedly been associated with suicidal behaviors, and depression has as well.1,50 - 62 Moreover, previous reports from the ACE Study have demonstrated strong, graded relationships between the number of adverse childhood experiences and the risk of alcohol or illicit substance abuse and depressive disorders.23, 24,28 Although a temporal relationship between the onset of substance abuse or depressive disorders and lifetime suicide attempts in the ACE Study cohort is uncertain, our analysis of the potential mediating effects of these known risk factors provides evidence that for some persons, adverse childhood experiences play a role in the development of substance abuse or depression.

In the Native Title Report 2007, I expressed a number of concerns about the changes including the amount of ministerial discretion in recognising these bodies, the additional administrative burdens placed on them, the uncertain position that bodies with short recognition periods are put in, and the preclusion of judicial review for the decision.