Sentences with phrase «with uncertain results»

The prospect of a referendum with an uncertain result has already caused a great deal of disarray, and those who count the costs of a possible Brexit...

Not exact matches

At the best of times, everything a CMO does is a gamble with ephemeral and uncertain results; that's a hundred times truer now, with marketing tools multiplying faster than anyone could truthfully claim to keep up with.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

But that can be difficult and even dangerous work, often with much weaker and more uncertain results.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Many supporters of delay also argued that the President's Memorandum has rendered the ultimate fate of the Fiduciary Rule and PTEs uncertain and that proceeding with the April 10, 2017 applicability date in the face of this uncertainty would impose unnecessary costs and burdens on the financial services industry and result in unnecessary confusion to investors inasmuch as products, services, and advisory practices could change after completion of the examination.

Moreover, our international expansion efforts have resulted and will continue to result in increased costs and are subject to a variety of risks, including increased competition, uncertain enforcement of our intellectual property rights, more complex distribution logistics, and the complexity of compliance with foreign laws and regulations.

Finally, preoccupation with the fascinations of progressive scientific discovery and with the material products of technology has turned man's attention away from the more uncertain and outwardly less rewarding results of the religious life.

Harry Angstrom is indeed caught in the hard passage from youth to age, and he negotiates the narrow divide between the angels and the apes with only uncertain results.

Football like life is uncertain... What is certain however is that following the same failed strategy year after year and expecting a different result is a sign of ineptitude if not madness... Our best 11 ain't up to it largely because it doesn't threaten and unthreatened teams also mean there is more pressure on our defence as well... So a bit of tinkering in the middle of park ain't going to deliver titles that is for sure... Draxler plus a mobile striker is needed... So unless the idiote grenouille is willing to shelve out 80m can kiss titles goodbye now... He can recover 30 - 40m with obvious sales of mediocre attacking options so not too onerous but at this rate it's déjà vu all over again

With the results still uncertain in Rep. Charlie Rangel's most difficult primary battle so far, attention has turned to the opening of absentee and affidavit ballots by the city Board of Election.

The authors note that the contribution of ribavirin to SVR12 remains uncertain because of the small sample sizes; results suggest that inclusion of ribavirin with the regimen may be considered for patients with genotype 1a infection.

The results for breast cancer are in line with previous research, but the true effect of alcohol on risk of ischaemic heart disease remains uncertain, say the editorial authors.

B: By its nature, science is an uncertain business, and predicting outcomes and results with certainty is foolhardy.

Climate change effects on the geographical distribution and incidence of vector - borne diseases in other countries where these diseases are already found can also affect North Americans, especially as a result of increasing trade with, and travel to, tropical and subtropical areas.63, 197 Whether climate change in the U.S. will increase the chances of domestically acquiring diseases such as dengue fever is uncertain, due to vector - control efforts and lifestyle factors, such as time spent indoors, that reduce human - insect contact.

This lack of positive communication allows the voices of those opposed to animal research to dominate public discourse; «alternative facts» become perceived truths with the result that public and political opinion is often uncertain on the use of animals in research.

Treatment guidelines recommend that women with uncertain genetic results not be treated as aggressively as women who test positive for BRCA 1 or 2, Kurian noted.

Regardless of how the fee structure, if any, is structured, it still represents a significantly lower cost than a night on the town with high aspirations and uncertain results.

Whether such material has captivated readers and viewers as much as Katniss» relatable plight, the result of a noble volunteering in her younger sister's place, and her love triangle with Peeta and local heartthrob Gale Hawthorne (Liam Hemsworth) is uncertain.

The surprise is that this kind of personality - based trick has resulted in the most searching and affecting performance of the actor's career: his Ivan is an organized, surface - only wastrel who has admitted to his limitations and made peace with them, beautifully balancing the title character's uncertain yearnings.

As a result, whenever charter schools want to rezone a building for their use, they must go through a relatively arduous and uncertain city - level process, with costs that operators cited at upward of $ 65,000.

They picked problems of practice for which a positive result was virtually guaranteed rather than difficult challenges with more uncertain outcomes.

While President George W. Bush left office with an uncertain education legacy — his signature initiative, No Child Left Behind, has had mixed results — Governor Bush of Texas achieved genuine success as an education reformer, and the state's schools still bear the mark of his influence.

Public education is far too important to treat it like a science experiment, with fuzzy methodology and uncertain results.

However, the «observed» data on this is itself somewhat uncertain — for instance, comparing the SAGE results (reported in Gray et al, 2011) with the SABER results (Merkel et al, 2011), shows a big difference in how large the ozone response is.

Note that the sign of precipitation trends in areas most directly impacted by the NAO such as southern Europe and the west coasts of Norway, the U.K. and Iceland, remains uncertain even for the next 50 years (Fig. 10d) consistent with the results shown in Figs.

Why isn't a TCR type of simulation, but instead using actual history and 200 year projected GHG levels in the atmosphere, that would produce results similar to a TCR simulation (at least for the AGW temp increase that would occur when the CO2 level is doubled) and would result in much less uncertainty than ECS (as assessed by climate model dispersions), a more appropriate metric for a 300 year forecast, since it takes the climate more than 1000 years to equilibrate to the hypothesized ECS value, and we have only uncertain methods to check the computed ECS value with actual physical data?

These results are why I question the use of monthly data with its autocorrelations (that have to be corrected with methods such as Cochrane - Orcutt) when the annual data does not require corrections (that could be of uncertain validity — see Steve M remarks on C - O CIs versus those CIs derived using maximum liklihood approach).

By doing so not only do we eliminate a whole bunch of make work with questionable / uncertain results, and we end all the complaints data falsification and quibbling over whose method really does find the «holy grail of the climate signal» in the US surface temperature record.

E.g., research assumes greenhouse gas emissions cause warming without explicitly stating humans are the cause»... carbon sequestration in soil is important for mitigating global climate change» (4a) No position Does not address or mention the cause of global warming (4b) Uncertain Expresses position that human's role on recent global warming is uncertain / undefined «While the extent of human - induced global warming is inconclusive...» (5) Implicit rejection Implies humans have had a minimal impact on global warming without saying so explicitly E.g., proposing a natural mechanism is the main cause of global warming»... anywhere from a major portion to all of the warming of the 20th century could plausibly result from natural causes according to these results» (6) Explicit rejection without quantification Explicitly minimizes or rejects that humans are causing global warming»... the global temperature record provides little support for the catastrophic view of the greenhouse effect» (7) Explicit rejection with quantification Explicitly states that humans are causing less than half of global warming «The human contribution to the CO2 content in the atmosphere and the increase in temperature is negligible in comparison with other sources of carbon dioxide emission»»

With expectations getting lowered all over the place, the future of any truly productive results uncertain, and peaceful protests rising up with greater force — and police using force to beat them back — the legacy of the COP15 climate talks is entirely up in the With expectations getting lowered all over the place, the future of any truly productive results uncertain, and peaceful protests rising up with greater force — and police using force to beat them back — the legacy of the COP15 climate talks is entirely up in the with greater force — and police using force to beat them back — the legacy of the COP15 climate talks is entirely up in the air.

With expectations getting lowered all over the place, the future of any truly productive results uncertain, and peaceful protests rising up with greater force — and police using force to beat them back — the legacy of the CWith expectations getting lowered all over the place, the future of any truly productive results uncertain, and peaceful protests rising up with greater force — and police using force to beat them back — the legacy of the Cwith greater force — and police using force to beat them back — the legacy of the COP15

(1) where the previous decision does not reflect the values of the Canadian Charter of Rights and Freedoms; (2) where the previous decision is inconsistent with or «attenuated» by a later decision of the Court; (3) where the social, political, or economic assumptions underlying a previous decision are no longer valid in contemporary society; (4) where the previous state of law was uncertain or where a previous decision caused uncertainty; and, (5) in criminal cases, where the result of overruling a prior decision is to establish a rule favourable to the accused.

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